Now showing items 1-9 of 9

    • Antiproliferative and proapoptotic activities of aza-annulated naphthoquinone analogs 

      Suárez Rozas, Cristian; Simpson, Sebastián; Fuentes Retamal, Sebastián; Catalán, Mabel; Ferreira, Jorge; Theoduloz, Cristina; Mella, Jaime; Cabezas, David; Cassels Niven, Bruce; Yáñez, Claudia; Castro Castillo, Vicente (Elsevier Ltd, 2019)
      © 2018 1,4-Naphthoquinone derivatives have been widely documented with regard to their biological properties, and particularly their anticancer activities. In the 9,10-anthraquinone family, aza-annulation involving one of ...
    • Cardiac fibroblast death by ischemia/reperfusion is partially inhibited by IGF-1 through both PI3K/Akt and MEK-ERK pathways 

      Vivar, Raúl; Humeres, Claudio; Varela, Marcelo; Ayala, Pedro; Guzmán, Nancy; Olmedo, Ivonne; Catalán, Mabel; Boza, Pía; Muñoz, Claudia; Díaz Araya, Guillermo (2012)
      Cardiac fibroblast (CF) death by ischemia/reperfusion (I/R) has major implications for cardiac wound healing. Although IGF-1 has well-known cytoprotective effects, no study has been done on CF subjected to simulated ...
    • Destabilization of mitochondrial functions as a target against breast cancer progression: Role of TPP+-linked-polyhydroxybenzoates 

      Sandoval Acuña, Cristian; Fuentes Retamal, Sebastián; Guzmán Rivera, Daniela; Peredo Silva, Liliana; Madrid Rojas, Matías; Rebolledo, Solange; Castro Castillo, Vicente; Pavani, Mario; Catalán, Mabel; Maya Arango, Juan; Jara, Jose A.; Parra, Eduardo; Calaf, Gloria M.; Speisky Cosoy, Hernán; Ferreira Parker, Jorge (2016)
      Mitochondrion is an accepted molecular target in cancer treatment since it exhibits a higher transmembrane potential in cancer cells, making it susceptible to be targeted by lipophilic-delocalized cations of triphenylphosphonium ...
    • Differential regulation of collagen secretion by kinin receptors in cardiac fibroblast and myofibroblast 

      Catalán, Mabel; Smolic, Christian; Contreras, Ariel; Ayala, Pedro; Olmedo, Ivonne; Copaja, Miguel; Boza, Pía; Vivar, Raúl; Avalos, Yennifer; Lavandero González, Sergio; Velarde, Victoria; Díaz Araya, Guillermo (2012)
      Kinins mediate their cellular effects through B1 (B1R) and B2 (B2R) receptors, and the activation of B2R reduces collagen synthesis in cardiac fibroblasts (CF). However, the question of whether B1R and/or B2R have a role ...
    • Electrochemistry of interaction of 2-(2-nitrophenyl)-benzimidazole derivatives with DNA 

      Catalán, Mabel; Álvarez Lueje, Alejandro; Bollo Dragnic, Soledad (2010)
      In this study the interaction between new benzimidazole molecules, 2-(2-nitrophenyl)-1H-benzimidazole (NB) and N-benzoyl-2-(2-nitrophenyl)-benzimidazole (BNB), with dsDNA and ssDNA was assessed at pH 7.4. Using differential ...
    • EPAC expression and function in cardiac fibroblasts and myofibroblasts 

      Olmedo, Ivonne; Muñoz, Claudia; Guzmán, Nancy; Catalán, Mabel; Vivar, Raúl; Ayala, Pedro; Humeres Martínez, Claudio; Aránguiz, Pablo; García Nannig, Lorena; Velarde, Victoria; Díaz Araya, Guillermo (Elsevier, 2013)
      In the heart, cardiac fibroblasts (CF) and cardiac myofibroblasts (CMF) are the main cells responsible for wound healing after cardiac insult. Exchange protein activated by cAMP (EPAC) is a downstream effector of cAMP, ...
    • Simvastatin disrupts cytoskeleton and decreases cardiac fibroblast adhesion, migration and viability 

      Copaja, Miguel; Venegas, Daniel; Aranguiz, Pablo; Canales, Jimena; Vivar, Raúl; Avalos, Yennifer; García Nannig, Lorena; Chiong Lay, Mario; Olmedo, Ivonne; Catalán, Mabel; Leyton Campos, Lisette; Lavandero González, Sergio; Díaz Araya, Guillermo (Elsevier, 2012)
      Statins reduce the isoprenoids farnesyl and geranylgeranyl pyrophosphate, essential intermediates, which control a diversity of cellular events such as cytoskeleton integrity, adhesion, migration and viability. Cardiac ...
    • Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts 

      Copaja, Miguel; Venegas, Daniel; Aránguiz, Pablo; Canales, Jimena; Vivar, Raúl; Catalán, Mabel; Olmedo, Ivonne; Rodríguez, Andrea E.; Chiong Lay, Mario; Leyton Campos, Lisette; Lavandero González, Sergio; Díaz Araya, Guillermo (2011)
      Several clinical trials have shown the beneficial effects of statins in the prevention of coronary heart disease. Additionally, statins promote apoptosis in vascular smooth muscle cells, in renal tubular epithelial cells ...
    • TGF-β1 prevents simulated ischemia/reperfusion-induced cardiac fibroblast apoptosis by activation of both canonical and non-canonical signaling pathways 

      Vivar, Raúl; Humeres, Claudio; Ayala, Pedro; Olmedo, Ivonne; Catalán, Mabel; García Nannig, Lorena; Lavandero González, Sergio; Díaz Araya, Guillermo (2013)
      Ischemia/reperfusion injury is a major cause of myocardial death. In the heart, cardiac fibroblasts play a critical role in healing post myocardial infarction. TGF-β1 has shown cardioprotective effects in cardiac damage; ...