Now showing items 1-4 of 4

    • Advances in Fetal and Neonatal Physiology 

      Giussani, Dino A.; Niu, Youguo; Herrera Videla, Emilio; Richter, Hans G.; Camm, Emily J.; Thakor, Avnesh S.; Kane, Andrew D.; Hansell, Jeremy A.; Brain, Kirsty L.; Skeffington, Katie L.; Itani, Nozomi; Wooding, F. B. Peter; Cross, Christine M.; Allison, Beth J. (Springer, 2014)
      The quality of the intrauterine environment interacts with our genetic makeup to shape the risk of developing disease in later life. Fetal chronic hypoxia is a common complication of pregnancy. This chapter reviews how ...
    • Developmental programming of cardiovascular dysfunction by prenatal hypoxia and oxidative stress 

      Giussani, Dino A.; Camm, Emily J.; Niu, Youguo; Richter, Hans G.; Blanco, Carlos E.; Gottschalk, Rachel; Blake, E. Zachary; Horder, Katy A.; Thakor, Avnesh S.; Hansell, Jeremy A.; Kane, Andrew D.; Wooding, F. B.Peter; Cross, Christine M.; Herrera, Emilio A. (2012)
      Fetal hypoxia is a common complication of pregnancy. It has been shown to programme cardiac and endothelial dysfunction in the offspring in adult life. However, the mechanisms via which this occurs remain elusive, precluding ...
    • Melatonin and vitamin C increase umbilical blood flow via nitric oxide-dependent mechanisms 

      Thakor, Avnesh S.; Herrera, Emilio A.; Serón Ferré, María; Giussani, Dino A. (2010)
      Inadequate umbilical blood flow leads to intrauterine growth restriction, a major killer in perinatal medicine today. Nitric oxide (NO) is important in the maintenance of umbilical blood flow, and antioxidants increase NO ...
    • Melatonin modulates the fetal cardiovascular defense response to acute hypoxia 

      Thakor, Avnesh S.; Allison, Beth J.; Niu, Youguo; Botting, Kimberley J.; Serón Ferré, María; Herrera Videla, Emilio; Giussani, Dino A. (Wiley & Sons, 2015)
      Experimental studies in animal models supporting protective effects on the fetus of melatonin in adverse pregnancy have prompted clinical trials in human pregnancy complicated by fetal growth restriction. However, the ...