Now showing items 1-20 of 20

    • Activation of Chymotrypsin-Like Activity of the Proteasome during Ischemia Induces Myocardial Dysfunction and Death 

      Sánchez, Gina; Berrios, Daniela; Olmedo, Ivonne; Pezoa, Javier; Riquelme, Jaime A.; Montecinos, Luis; Pedrozo Cibils, Zully; Donoso Laurent, Paulina (Public Library Science, 2016)
      Inhibitors of the ubiquitin-proteasome system improve hemodynamic parameters and decrease the infarct size after ischemia reperfusion. The molecular basis of this protection is not fully understood since most available ...
    • Angiotensin II-regulated autophagy is required for vascular smooth muscle cell hypertrophy 

      Mondaca Ruff, David; Riquelme, Jaime A.; Quiroga, Clara; Norambuena Soto, Ignacio; Sanhueza Olivares, Fernanda; Villar-Fincheira, Paulina; Hernández-Díaz, Tomás; Cancino Arenas, Nicole; San Martin, Alejandra; García Nannig, Lorena; Lavandero González, Sergio; Chiong Lay, Mario (Frontiers Media S.A., 2019)
      Copyright © 2019 Mondaca-Ruff, Riquelme, Quiroga, Norambuena-Soto, Sanhueza-Olivares, Villar-Fincheira, Hernández-Díaz, Cancino-Arenas, San Martin, García, Lavandero and Chiong.Hypertension is a disease associated to ...
    • Autophagy mediates tumor necrosis factor-alpha-induced phenotype switching in vascular smooth muscle A7r5 cell line 

      García Miguel, Marina; Riquelme, Jaime A.; Norambuena Soto, Ignacio; Morales, Pablo E.; Sanhueza Olivares, Fernanda; Núñez Soto, Constanza Belén; Mondaca Ruff, David; Cancino Arenas, Nicole; San Martín, Alejandra; Chiong Lay, Mario (Public library science, 2018-05-11)
      Vascular smooth muscle cells (VSMC) dedifferentiation from a contractile to a synthetic phenotype contributes to atherosclerosis. Atherosclerotic tissue has a chronic inflammatory component with high levels of tumor necrosis ...
    • Autophagy mediates tumor necrosis factor-α-induced phenotype switching in vascular smooth muscle A7r5 cell line 

      García Miguel, Marina; Riquelme, Jaime A.; Norambuena Soto, Ignacio; Morales, Pablo E.; Sanhueza Olivares, Fernanda; Núñez Soto, Constanza Belén; Mondaca Ruff, David; Cancino Arenas, Nicole; San Martín, Alejandra; Chiong Lay, Mario (Public Library of Science, 2018)
      This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the ...
    • Cardioprotection mediated by exosomes is impaired in the setting of type II diabetes but can be rescued by the use of non-diabetic exosomes in vitro 

      Davidson, Sean M.; Riquelme, Jaime A.; Takov, Kaloyan; Vicencio, José M.; Boi-Doku, Claire; Khoo, Vanessa; Doreth, Christian; Radenkovic, Dina; Lavandero González, Sergio; Yellon, Derek M. (Blackwell, 2018)
      Many patients with ischaemic heart disease also have diabetes. As myocardial infarction is a major cause of mortality and morbidity in these patients, treatments that increase cell survival in response to ischaemia and ...
    • Counter-regulatory renin-angiotensin system in cardiovascular disease 

      Ocaranza, María Paz; Riquelme, Jaime; García, Lorena; Jalil, Jorge E.; Chiong, Mario; Santos, Robson A. S.; Lavandero González, Sergio (Nature Publishing Group, 2020)
      The non-canonical axis of the renin-angiotensin system (RAS) has an important role in cardiovascular physiology and disease. In this Review, Ocaranza and colleagues discuss the interplay between components of the ...
    • Drp1 loss-of-function reduces cardiomyocyte oxygen dependence protecting the heart from ischemia-reperfusion injury 

      Zepeda Iriarte, Ramiro; Kuzmicic, Jovan; Parra Ortiz, Valentina; Troncoso Cotal, Rodrigo; Pennanen, Christian; Riquelme, Jaime A.; Pedrozo Cibils, Zully; Chiong Lay, Mario; Sánchez, Gina; Lavandero González, Sergio (Lippincott Williams and Wilkins, 2014)
      Mitochondria are key organelles for ATP production in cardiomyocytes, which is regulated by processes of fission and fusion. We hypothesized that the mitochondria fusion protein dynamin-related protein 1 (Drp1) inhibition, ...
    • Editorial commentary: Cardiometabolic diseases and gut microbiota–removing the veil 

      Riquelme, Jaime A.; Ferreccio, Catterina; Lavandero González, Sergio (Elsevier Inc., 2018)
    • Editorial commentary: Cardiometabolic diseases and gut microbiota–removing the veil 

      Riquelme, Jaime A.; Ferreccio, Catterina; Lavandero González, Sergio (Elsevier Inc., 2019)
    • High fat diet induced obesity produces spontaneous ventricular arrhythmias and increases the activity of ryanodine receptors in mice 

      Sánchez, Gina; Araneda, Felipe; Peña, Juan Pedro; Finkelstein, José Pablo; Riquelme, Jaime A.; Montecinos, Luis; Barrientos Briones, Genaro; Llanos Vidal, Paola; Pedrozo Cibils, Zully; Said, Matilde; Bull Simpfendorfer, Ricardo; Donoso Laurent, Paulina (MDPI, 2018)
      Ventricular arrhythmias are a common cause of sudden cardiac death, and their occurrence is higher in obese subjects. Abnormal gating of ryanodine receptors (RyR2), the calcium release channels of the sarcoplasmic reticulum, ...
    • High-fat-diet-induced obesity produces spontaneous ventricular arrhythmias and increases the activity of ryanodine receptors in mice 

      Sánchez, Gina; Loyola Araneda, Felipe; Peña, Juan Pedro; Finkelstein Muñoz, José Pablo; Riquelme, Jaime A.; Montecinos, Luis; Barrientos, Genaro; Llanos Vidal, Paola; Pedrozo Cibils, Zully; Said, Matilde; Bull, Ricardo; Donoso Laurent, Paulina (MDPI AG, 2018)
      © 2018 by the authors. Licensee MDPI, Basel, Switzerland. Ventricular arrhythmias are a common cause of sudden cardiac death, and their occurrence is higher in obese subjects. Abnormal gating of ryanodine receptors (RyR2), ...
    • Increased production of functional small extracellular vesicles in senescent endothelial cells 

      Riquelme, Jaime; Takov, Kaloyan; Santiago Fernández, Concepción; Rossello, Xavier; Lavandero González, Sergio; Yellon, Derek M.; Davidson, Sean M. (Wiley, 2020)
      Small extracellular vesicles (EVs) are novel players in vascular biology. However, a thorough understanding of their production and function remains elusive. Endothelial senescence is a key feature of vascular ageing and ...
    • New Molecular Insights of Insulin in Diabetic Cardiomyopathy 

      Westermeier, Francisco; Riquelme, Jaime A.; Pavez, Mario; Garrido, Valeria; Díaz, Ariel; Verdejo, Hugo E.; Castro, Pablo F.; García Nannig, Lorena; Lavandero González, Sergio (Frontiers Media S.A., 2016-04)
      Type 2 diabetes mellitus (T2DM) is a highly prevalent disease worldwide. Cardiovascular disorders generated as a consequence of T2DM are a major cause of death related to this disease. Diabetic cardiomyopathy (DCM) is ...
    • Novel therapies targeting cardioprotection and regeneration 

      Garrido, Valeria; Mendoza Torres, Evelyn; Riquelme, Jaime A.; Díaz, Ariel; Pizarro, Marcela; Bustamante, Mario; Chávez, Myra N.; Ocaranza, María Paz; Mellado, Rosemarie; Corbalán, Ramón; Allende Connelly, Miguel; Lavandero González, Sergio (Bentham Science Publishers, 2017)
      Cardiovascular disease is the leading cause of death worldwide. The heart is susceptible to pathologies that impact the myocardium directly, such as myocardial infarction and consequent heart failure, as well as conditions ...
    • Plasma Exosomes Protect the Myocardium From Ischemia-Reperfusion Injury 

      Vicencio, José M.; Yellon, Derek M.; Sivaraman, Vivek; Das, Debashish; Boi-Doku, Claire; Arjun, Sapna; Zheng, Ying; Riquelme, Jaime A.; Kearney, Jessica; Sharma, Vikram; Multhoff, Gabriele; Hall, Andrew R.; Davidson, Sean M. (Elsevier, 2015)
      BACKGROUND Exosomes are nanometer-sized vesicles released from cells into the blood, where they can transmit signals throughout the body. Shown to act on the heart, exosomes’ composition and the signaling pathways they ...
    • Protection of the myocardium against ischemia/reperfusion injury by angiotensin-(1–9) through an AT2R and Akt-dependent mechanism 

      Mendoza Torres, Evelyn; Riquelme, Jaime A.; Vielma, Alejandra; Sagredo, Andrea Ramirez; Gabrielli, Luigi; Bravo Sagua, Roberto; Jalil Milad, Jorge; Rothermel, Beverly A.; Sánchez, Gina; Ocaranza, María Paz; Lavandero González, Sergio (Academic Press, 2018)
      © 2018 Elsevier Ltd Angiotensin-(19), a peptide of the non-classical renin angiotensin system, has been shown to prevent and revert hypertension and cardiac hypertrophy. We hypothetized that systemic delivery of angiotensin-(1–9) ...
    • Regulation of Cardiac Autophagy by Insulin-like Growth Factor 1 

      Troncoso, Rodrigo; Díaz Elizondo, Jessica; Espinoza, Sandra P.; Navarro Márquez, Mario F.; Oyarzún, Alejandra P.; Riquelme, Jaime A.; García Carvajal, Ivonne; Díaz Araya, Guillermo; García Nannig, Lorena; Hill, Joseph A.; Lavandero González, Sergio (2013-07)
      Insulin-like growth factor-1 (IGF-1) signaling is a key pathway in the control of cell growth and survival. Three critical nodes in the IGF-1 signaling pathway have been described in cardiomyocytes: protein kinase ...
    • Role of PI3K in myocardial ischaemic preconditioning: mapping pro-survival cascades at the trigger phase and at reperfusion 

      Rossello, Xavier; Riquelme, Jaime A.; Davidson, Sean M.; Yellon, Derek M. (Wiley, 2018)
      The Reperfusion Injury Salvage Kinase (RISK) pathway is considered the main pro-survival kinase cascade mediating the ischaemic preconditioning (IPC) cardioprotective effect. To assess the role of PI3K-Akt, its negative ...
    • The role of PI3K alpha isoform in cardioprotection 

      Rossello, Xavier; Riquelme, Jaime A.; He, Zhenhe; Taferner, Stasa; Vanhaesebroeck, Bart; Davidson, Sean M.; Yellon, Derek M. (Springer, 2017)
      Ischemic preconditioning (IPC) limits myocardial infarct size through the activation of the PI3K-Akt signal cascade; however, little is known about the roles of individual PI3K isoforms in cardioprotection. We aimed, ...
    • Therapeutic targeting of autophagy in myocardial infarction and heart failure 

      Riquelme, Jaime A.; Chávez, Myra N.; Mondaca Ruff, David; Bustamante, Mario; Vicencio, José M.; Quest, Andrew F. G.; Lavandero González, Sergio (Taylor & Francis, 2016)
      Introduction: Myocardial infarction (MI) is the leading cause of death. When MI is not lethal, heart failure (HF) is a major consequence with high prevalence and poor prognosis. The targeting of autophagy represents a ...