Browsing by Author "f9b533ca-5759-4492-aaeb-d71e16432af0"
Now showing items 1-7 of 7
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Quintanilla González, María Elena; Tampier de Jong, Lutske; Valle-Prieto, Araceli; Sapag, Amalia; Israel Jacard, Yedy (FEDERATION AMER SOC EXP BIOL, 2005-06)Animals selectively bred for a desirable trait retain wanted genes but exclude genes that may counteract the expression of the former. The possible interactions between selected and excluded genes cannot be readily studied ...
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Ocaranza, Paula; Quintanilla González, María Elena; Tampier de Jong, Lutske; Karahanian, Eduardo; Sapag, Amalia; Israel Jacard, Yedy (2008)Background: Some gene polymorphisms strongly protect against the development of alcoholism. A large proportion of East Asians carry a protective inactivating mutation in aldehyde dehydrogenase (ALDH2*2). These subjects ...
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Rivera Meza, Mario; Quintanilla González, María Elena; Tampier de Jong, Lutske; Mura, Casilda V.; Sapag, Amalia; Israel Jacard, Yedy (2010)Humans who carry a point mutation in the gene coding for alcohol dehydrogenase-1B (ADH1B*2; Arg47His) are markedly protected against alcoholism. Although this mutation results in a 100-fold increase in enzyme activity, it ...
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Sapag, Amalia; González Martínez, Ginez Andrés; Lobos González, Lorena; Encina, Gonzalo; Tampier de Jong, Lutske; Israel Jacard, Yedy; Quintanilla González, María Elena (2009)OBJECTIVE: Alcohol is detoxified in the liver by oxidizing enzymes that require nicotinamide adenine dinucleotide (NAD) such that, in the rat, the availability of NAD contributes to control voluntary ethanol intake. The ...
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Quintanilla González, María Elena; Tampier de Jong, Lutske; Sapag, Amalia; Israel Jacard, Yedy (Lippincott Williams & Wilkins, 2005)Dependence on alcohol, a most widely used drug, has a heritability of 50-60%. Wistar-derived rats selectively bred as low-alcohol consumers for many generations present an allele (Aldh22) of mitochondrial aldehyde ...
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Cortínez, Gabriel; Sapag, Amalia; Israel Jacard, Yedy (2009)Liver alcohol dehydrogenase oxidizes ethanol to acetaldehyde, which is further oxidized to acetate by aldehyde dehydrogenase-2 (ALDH2*1). Individuals who carry a low-activity ALDH2 (ALDH2*2) display high blood acetaldehyde ...
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Quintanilla González, María Elena; Israel Jacard, Yedy; Sapag, Amalia; Tampier de Jong, Lutske (BLACKWELL, 2006-09)Ethanol non-drinker (UChA) and drinker (UChB) rat lines derived from an original Wistar colony have been selectively bred at the University of Chile for over 70 generations. Two main differences between these lines are ...