Now showing items 1-4 of 4

    • Fibroblast Primary Cilia Are Required for Cardiac Fibrosis 

      Villalobos, Elisa; Criollo Céspedes, Alfredo; Schiattarella, Gabriele G.; Altamirano, Francisco; French, Kristin M.; May, Herman I.; Jiang, Nan; Nguyen, Ngoc Uyen Nhi; Romero, Diego; Roa, Juan Carlos; García Nannig, Lorena; Díaz Araya, Guillermo; Morselli, Eugenia; Ferdous, Anwarul (NLM (Medline), 2019)
      BACKGROUND: The primary cilium is a singular cellular structure that extends from the surface of many cell types and plays crucial roles in vertebrate development, including that of the heart. Whereas ciliated cells have ...
    • FoxO1-Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth 

      Ferdous, Anwarul; Wang, Zhao V.; Luo, Yuxuan; Li, Dan L.; Luo, Xiang; Schiattarella, Gabriele G.; Altamirano, Francisco; May, Herman I.; Battiprolu, Pavan K.; Nguyen, Annie; Rothermel, Beverly A.; Lavandero González, Sergio; Gillette, Thomas G.; Hill, Joseph A. (Nature, 2020)
      Forkhead box O (FoxO) proteins and thyroid hormone (TH) have well established roles in cardiovascular morphogenesis and remodeling. However, specific role(s) of individual FoxO family members in stress-induced growth and ...
    • Nitrosative stress drives heart failure with preserved ejection fraction 

      Schiattarella, Gabriele G.; Altamirano, Francisco; Tong, Dan; French, Kristin M.; Villalobos, Elisa; Kim, Soo Young; Luo, Xiang; Jiang, Nan; May, Herman I.; Wang, Zhao V.; Hill, Theodore M.; Mammen, Pradeep; Huang, Jian; Lee, Dong I.; Hahn, Virginia; Sharma, Kavita; Kass, David A.; Lavandero González, Sergio; Gillette, Thomas G.; Hill, Joseph A. (Nature Publishing Group, 2019)
      Heart failure with preserved ejection fraction (HFpEF) is a common syndrome with high morbidity and mortality for which there are no evidence-based therapies. Here we report that concomitant metabolic and hypertensive ...
    • Polycystin-2-dependent control of cardiomyocyte autophagy 

      Criollo Céspedes, Alfredo; Altamirano, Francisco; Pedrozo Cibils, Zully; Schiattarella, Gabriele G.; Li, Dan L.; Rivera‐Mejias, Pablo; Sotomayor Flores, Cristian; Parra, Valentina; Villalobos, Elisa; Battiprolu, Pavan K.; Jiang, Nan; May, Herman I.; Morselli, Eugenia; Somlo, Stefan; Smedt, Humbert de; Gillette, Thomas G.; Lavandero González, Sergio; Hill, Joseph A. (Elsevier, 2018-05)
      Aims: Considerable evidence points to critical roles of intracellular Ca2+ homeostasis in the modulation and control of autophagic activity. Yet, underlying molecular mechanisms remain unknown. Mutations in the gene (pkd2) ...