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Now showing items 27748-27767 of 91997

    • dSTORM microscopy evidences in HeLa cells clustered and scattered gamma H2AX nanofoci sensitive to ATM, ... 
      Liddle, Pablo; Jara Wilde, Jorge; Lafon Hughes, Laura; Castro, Iván; Hartel, Steffen; Folle, Gustavo (Springer, 2020)
      In response to DNA double-strand breaks (DSB), histone H2AX is phosphorylated around the lesion by a feed forward signal amplification loop, originating gamma H2AX foci detectable by immunofluorescence and confocal microscopy ...
    • DT-diaforasa impide la formación de oligómeros de α-sinucleína inducida por aminocromo 
      Cárdenas Muñoz, Sergio Patricio (Universidad de ChilePrograma Cybertesis, 2008)
    • DT-Diaphorase Prevents Aminochrome-Induced Alpha-Synuclein Oligomer Formation and Neurotoxicity 
      Muñoz, Patricia; Cárdenas, Sergio; Huenchuguala, Sandro; Briceño, Andrea; Couve, Eduardo; Paris Pizarro, Irmgard; Segura Aguilar, Juan (Oxford University Press, 2015)
      It was reported that aminochrome induces the formation of alpha synuclein (SNCA) oligomers during dopamine oxidation. We found that DT-diaphorase (NQO1) prevents the formation of SNCA oligomers in the presence of ...
    • DT-Diaphorase Prevents Aminochrome-Induced Lysosome Dysfunction in SH-SY5Y Cells 
      Meléndez, Catalina; Muñoz, Patricia; Segura Aguilar, Juan (Springer, 2019)
      Aminochrome has been reported to induce lysosomal dysfunction by inhibiting the vacuolar H-type ATPase localized inlysosome membrane. DT-diaphorase has been proposed to prevent aminochrome neurotoxicity but it is unknown ...
    • DT-diaphorase protects against autophagy induced by aminochrome dependent alpha synuclein oligomers 
      Muñoz, Patricia S.; Segura Aguilar, Juan (Springer, 2017)
      Alpha-synuclein (SNCA) oligomers have been reported to inhibit autophagy. Aminochrome-induced SNCA oligomers are neurotoxic, but the flavoenzyme DT-diaphorase prevents both their formation and their neurotoxicity. However, ...
    • DT-diaphorase protects astrocytes from aminochrome-induced toxicity 
      Huenchuguala, Sandro; Muñoz, Patricia; Graumann, Rebecca; Paris Pizarro, Irmgard; Segura Aguilar, Juan (Elsevier, 2016)
      Astrocytes are exposed to aminochrome via the oxidation of dopamine that is taken up from the synaptic cleft after its release from dopaminergic neurons. Glutathione transferase M2-2 (GSTM2) has been shown to protect ...
    • DUA y Desarrollo de Competencias Científicas en el Aula: aplicación de un diseño de Aprendizaje Consciente ... 
      Díaz Galindo, Constanza Alejandra (Universidad de Chile, 2024)
    • Dual and opposite roles of reactive oxygen species (ROS) in chagas disease: beneficial on the pathogen and ... 
      Maldonado Maldonado, Edio; Rojas, Diego A.; Morales, Sebastián; Miralles, Vicente; Solari Illescas, Aldo (Hindawi, 2020)
      Chagas disease is a neglected tropical disease, which affects an estimate of 6-7 million people worldwide. Chagas disease is caused by Trypanosoma cruzi, which is a eukaryotic flagellate unicellular organism. At the primary ...
    • Dual convergence for penalty proximal point algorithms in convex programming 
      Álvarez Daziano, Felipe; Carrasco, Miguel; Champion, Thierry (2007)
      We consider an implicit iterative method in convex programming which combines inexact variants of the proximal point algorithm, with parametric penalty functions. We investigate a multiplier sequence which is explicitly ...
    • Dual effect of serotonin on the dendritic growth of cultured hippocampal neurons: Involvement of 5-HT1A and ... 
      Rojas, P. S.; Aguayo, F.; Neira, D.; Tejos, M.; Aliaga, E.; Muñoz, J. P.; Parra, C. S.; Fiedler Temer, Jenny (Academic Press Inc., 2017)
      © 2017 Elsevier Inc. Serotonin acts through its receptors (5-HTRs) to shape brain networks during development and modulates essential functions in mature brain. The 5-HT1AR is mainly located at soma of hippocampal neurons ...
    • Dual Emission of a Novel (P,N) Re 
      Pizarro, Nancy; Duque, Mario; Chamorro, Eduardo; Nonell, Santi; Manzur Saffie, Jorge; De la Fuente, Julio; Günther Sapunar, Germán; Cepeda Plaza, Marjorie; Vega, Andrés (American Chemical Society, 2015)
      © 2015 American Chemical Society. The spectroscopic, electrochemical, and photophysical properties of the new complex [P,N-{(C<inf>6</inf>H<inf>5</inf>)<inf>2</inf>(C<inf>5</i ...
    • Dual Emission of a Novel (P,N) Re-I Complex: A Computational and Experimental Study on [P,N-{(C6H5)(2)(C5 ... 
      Pizarro, Nancy; Duque, Mario; Chamorro, Eduardo; Nonell, Santi; Manzur Saffie, Jorge; Fuente Urrutia, Julio de la; Günther Sapunar, Germán; Cepeda Plaza, Marjorie; Vega, Andrés (American Chemical Society, 2015)
      The spectroscopic, electrochemical, and photophysical properties of the new complex [P,N-{(C6H5)(2)(C5H4N)-P}Re(CO)(3)Br] are reported. The UV-vis spectrum in dichloromethane shows an absorption maximum centered at 315 rim ...
    • Dual hesitant fuzzy group decision making method and its application to supplier selection 
      Yu, Dejian; Li, Deng Feng; Merigó Lindahl, José (2016)
      The concept of dual hesitant fuzzy set arising from hesitant fuzzy set is generalized by including a function reflecting the decision maker's fuzziness about the non-membership degree of the information provided. This paper ...
    • Dual innervation of the brachialis muscle in the Chilean population Doble inervación del músculo braquial ... 
      Molina, Claudio; Uribe, Cristián; Heras, Álvaro; Astorga, Cristián; Lemus, Jorge; Rodríguez, Alberto (2011)
      The dual innervation of the brachialis muscle by the musculocutaneos nerve and branches from the radial nerve has been described by some anatomical texts and several scientific papers; however, there is no consensus about ...
    • Dual inotropic effect of harmaline on the rat heart atrial muscle 
      Carpenter, Robert; Diaz, Gabriela (1977)
      The effect of harmaline (HME) was analyzed in rat strips superfused in vitro. A dual inotropic action was found: the positive component was due to a transient catechol-mediated enhancement of the velocity of development ...
    • Dual IRE1 RNase functions dictate glioblastoma development 
      Lhomond, Stephanie; Avril, Tony; Dejeans, Nicolas; Hetz Flores, Claudio (Wiley, 2018)
      Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor aggressiveness. Evidence suggests that the endoplasmic reticulum (ER), a major site for protein folding and quality control, plays a critical ...
    • Dual modifications of alpha-galactosylceramide synergize to promote activation of human invariant natural ... 
      Chennamadhavuni, Divya; Saavedra-Avila, Noemi Alejandra; Carreño Marquez, Leandro J.; Guberman-Pfeffer, Matthew J.; Arora, Pooja; Yongqing, Tan; Koay, Hui-Fern); Godfrey, Dale I.; Keshipeddy, Santosh; Richardson, Stewart K.; Sundararaj, Srinivasan; Lo, Jae Ho; Wen, Xiangshu; Gascón, José A.; Yuan, Weiming; Rossjohn, Jamie; Le Nours, Jéroˆme; Porcelli, Steven A.; Howell, Amy R. (Cell press, 2018-05-17)
      Glycosylceramides that activate CD1d-restricted invariant natural killer T (iNKT) cells have potential therapeutic applications for augmenting immune responses against cancer and infections. Previous studies using mouse ...
    • Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer ... 
      Chennamadhavuni, Divya; Saavedra-Avila, Noemi Alejandra; Carreño, Leandro J.; Guberman-Pfeffer, Matthew J.; Arora, Pooja; Yongqing, Tang; Koay, Hui Fern; Godfrey, Dale I.; Keshipeddy, Santosh; Richardson, Stewart K.; Sundararaj, Srinivasan; Lo, Jae Ho; Wen, Xiangshu; (Elsevier Ltd, 2018)
      © 2018 Elsevier Ltd Glycosylceramides that activate CD1d-restricted invariant natural killer T (iNKT) cells have potential therapeutic applications for augmenting immune responses against cancer and infections. Previous ...
    • A Dual Ridge Broadband Orthomode Transducer for the 7-mm Band 
      Reyes Guzmán, Nicolás Andrés; Zorzi Avendaño, Pablo Ignacio; Pizarro Lucero, José; Finger Camus, Ricardo; Mena Mena, Fausto Patricio; Bronfman Aguiló, Leonardo (SPRINGER, 2012-12)
      In this work we present a Q-band waveguide orthomode transducer (OMT) based on a dual ridge structure. It was designed to be used in astronomical projects were an excellent broad-band performance is mandatory. Of particular ...
    • Dual wavefunctions in two-dimensional quantum mechanics 
      Hojman Guiñerman, Sergio; Asenjo, Felipe (Elsevier, 2020)
      It is shown that the Schrodinger equation for a large family of pairs of two-dimensional quantum potentials possess wavefunctions for which the amplitude and the phase are interchangeable, producing two different solutions ...