Browsing by Author "201-0010793"
Now showing items 21-40 of 44
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Valenzuela Pedevila, Jorge; Pessoa Mahana, Hernán; Atria Salas, Ana María; Contreras, Martín; Pezoa Olivares, Jacqueline (TAYLOR & FRANCIS INC., 2005)The synthesis of 2-(2-nitrophenyl)-1H-benzimidazole (1), 1-benzoyl-2-(2-nitrophenyl)-1H -benzimidazole (2), and 1-acetyl-2-(2-nitrophenyl)-1H-benzimidazole ( 3) is reported. Stable radical anions (1(center dot-), 2(center ...
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Araya Maturana, Ramiro; Gavin Sazatornil, J. A.; Heredia Moya, Jorge; Pessoa Mahana, Hernán; Weiss López, Boris (SOC BRASILEIRA QUIMICA, 2005-05)A systematic study about the long-range correlations observed in the HMBC spectra of a series of cis and trans 3-(4-oxo-4H-chromen-3-yl)-acrylic acid ethyl esters, and 5-hydroxy derivatives, was carried out. The results ...
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Pessoa, D.; Espinosa Bustos, Christian; Mella Raipán, Jaime A.; Canales Pacheco, Jorge; Pessoa Mahana, Hernán (ARKAT USA INC, 2009)The synthesis of 5H-benzimidazo [1,2-d] [1,4] benzodiazepin -6(7H)-ones 3a-e from readily available 2-(2-aminophenyl)-1H-benzo[d]imidazole derivatives 2a-e and 2-bromoacetyl bromide under microwave conditions is described. ...
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Nitrofuran drugs beyond redox cycling: Evidence of Nitroreduction-independent cytotoxicity mechanism Gallardo Garrido, C.; Cho, Y.; Cortés Ríos, J.; Vásquez Velásquez, David; Pessoa Mahana, C. David; Araya Maturana, R.; Pessoa Mahana, Hernán; Faúndez, M. (Elsevier, 2020)Nitrofurans (5-nitro-2-hydrazonylfuran as pharmacophore) are a group of widely used antimicrobial drugs but also associated to a variety of side effects. The molecular mechanisms that underlie the cytotoxic effects of ...
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Urra, Félix A.; Martínez Cifuentes, Maximiliano; Pavani, Mario; Lapier, Michel; Jaña Prado, Fabián; Parra, Eduardo; Maya Arango, Juan; Pessoa Mahana, Hernán; Ferreira Parker, Jorge; Araya Maturana, Ramiro (Elsevier, 2013)Tumor cells present a known metabolic reprogramming, which makes them more susceptible for a selective cellular death by modifying its mitochondrial bioenergetics. Anticancer action of the antioxidant 9,10- dihydroxy-4 ...
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Cuevas Morales, Ignacio Esteban (Universidad de Chile, 2008)En la presente tesis se describe la obtención de una serie de 1-Bencil-3-[4-Aril-1-piperazinil]carbonil-1H-Indoles 6(a-f) funcionalizadas como ligandos potencialmente bioactivos en los receptores D4 en el Sistema Nervioso ...
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Cerda Cavieres, Christopher David (Universidad de Chile, 2008)La presente Memoria se orientó al estudio y caracterización electro-analítica de una serie de derivados N-(4-R-benzoil)-2-(2-nitrofenil)-1-H-benzimidazoles como sustratos de interés biológico. Los compuestos estudiados ...
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Ron Higuera, Nadia Betsabé (Universidad de Chile, 2008)La depresión constituye un trastorno del estado anímico, que se expresa con una pérdida manifiesta del interés o de las actividades placenteras del vivir, atribuidas fundamentalmente a una alteración en la neurotransmisión ...
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Ugarte Núñez, Catalina de los Ángeles (Universidad de Chile, 2010)Las arilpiperazinas representan uno de los grupos de ligandos más estudiados frente al receptor 5HT1A. Estas estructuras destacan principalmente por poseer una actividad antidepresiva y ansiolítica. Asimismo el receptor ...
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Urra Faúndez, Félix; Córdova Delgado, Miguel; Lapier, Michel; Orellana Manzano, Andrea; Acevedo Arévalo, Luis; Pessoa Mahana, Hernán; González Vivanco, Jaime; Martínez Cifuentes, Maximiliano; Ramírez Rodríguez, Oney; Millas Vargas, Juan; Weiss López, Boris; Pavani, Mario; Ferreira Parker, Jorge; Araya Maturana, Ramiro (Academic Press Elsevier Science, 2016)Mitochondria participate in several distinctiveness of cancer cell, being a promising target for the design of anti-cancer compounds. Previously, we described that ortho-carbonyl hydroquinone scaffold 14 inhibits the complex ...
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Pessoa, D.; Valderrama Guerrero, Jaime Adolfo; Olmos, María G.; Espinoza, Omar; Pessoa Mahana, Hernán; Rojas de Arias, Antonieta; Nakayama, Héctor; Torres, Susana; Miret, Jorge (FREUND PUBLISHING HOUSE LTD, 2002)A series of 2-alkoxycarbonylbenzo[b]thiophene-4,7-quinones (11-15), prepared from the corresponding acid 5, were tested in vitro against trypomastigote form of Trypanosome cruzi. The influence of the lypophilia and oxidant ...
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Valderrama, Jaime A.; Benites, Julio; Cortés, Manuel; Pessoa Mahana, Hernán; Prina, Eric; Fournet, Alain (PERGAMON-ELSEVIER SCIENCE LTD, 2003-11-03)The reaction of (+)-euryfuran 1 with several benzo-, naphtho- and benzo[b]thiophene-1,4-quinones in acetic acid yields the corresponding euryfuryl-1.4-quinones 3, 5, 7, 8, 10, 12, and 14. The structure of compounds 7, 8, ...
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Quiroga Campano, Cinthia del Rosario; Gómez Machuca, Horacio Exequiel; Jullian Matthaei, Carolina; Fuente Urrutia, Julio de la; Pessoa Mahana, Hernán; Saitz Barría, Claudio (Springer, 2014)The present work describes a study of complexation efficiency and selectivity of calix[4]arenes bearing benzoimidazolyl, benzothiazolyl, and benzoxazolyl heterocycles (5–7) towards several selected metal ions ...
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Pessoa Mahana, Hernán; Valderrama Guerrero, Jaime Adolfo (MARCEL DEKKER INC, 2000)The synthesis of 6-hydroxy-7-nitro-1-benzazepine-2-one 7 from 5-hydroxy-1 -tetralone 1 and 6-hydroxy-1 -benzazepine-2-one 2 is described. Bromination of 6-hydroxy- 1-benzazepine-2-one 2 with NBS in ethyl acetate afforded ...
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Pessoa Mahana, Hernán; Cuevas M., Ignacio; Pessoa Mahana, Carlos David; Araya Maturana, Ramiro; Almodovar, Iriux; Saitz Barría, Claudio (2011)The synthesis of a series of functionalized 1-Benzyl-3-[4-Aryl-1-piperazingl]carbonyl-1H-Indoles 6(a-f), as a potential new class of bioactive ligands at D4 receptors is reported. The synthetic strategy took place through ...
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Pessoa Mahana, David; Núñez, Andrés; Espinosa Bustos, Christian; Mella Raipán, Jaime A.; Pessoa Mahana, Hernán (2010)The synthesis of a series of substituted arylpiperazines linked to a 2-(pyridin-3-yl)-1H-benzo[d]imidazole scaffold through an alkylic linker is reported. The novel 1-(2-(4-arylpiperazin-1-yl)alkyl)-2-(pyridin-3-yl)-1H-b ...
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Pessoa Mahana, David; Núñez, Andrés; Espinosa Bustos, Christian; Mella Raipán, Jaime A.; Pessoa Mahana, Hernán (2010)
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Romero Parra, Javier; Mella Ralpán, Jaime; Palmieri, Vittoria; Allara, Marco; Torres, María José; Pessoa Mahana, Hernán; Iturriaga-Vásquez, Patricio; Escobar, Rossy; Faúndez, Mario; Di Marzo, Vincenzo; Pessoa Mahana, Carlos David (Elsevier, 2016)Herein we report the design, synthesis, bioinformatic and biological studies of benzimidazole and benzothiophene derivatives as new cannabinoid receptor ligands. To test the hypothesis that the lack of a hydrogen bond ...
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Pessoa Mahana, Hernán; González Lira, Christian; Fierro, Angélica; Zapata Torres, Gerald Amilcar; Pessoa Mahana, Carlos David; Ortiz Severin, Javiera; Iturriaga-Vásquez, Patricio; Reyes Parada, Miguel; Silva Matus, Paul; Saitz Barría, Claudio; Araya Maturana, Ramiro (Elsevier, 2013)A series of 3-(3-(4-(3-(1H-indol-3-yl)propyl)piperazin-1-yl)propyl)-1H-indole derivatives (3a–d and 5a– f) as homo- and hetero-bis-ligands, were synthesized and evaluated for in vitro affinity at the serotonin transporter ...
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Pessoa Mahana, Hernán; Recabarren Gajardo, Gonzalo Iván; Fiedler Temer, Jenny; Zapata Torres, Gerald Amilcar; Pessoa Mahana, Carlos David; Saitz Barría, Claudio; Araya Maturana, Ramiro (2012)A series of novel benzobthiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1-one derivatives 6a–f, 7a–f and their corresponding alcohols 8a–f were synthesized and evaluated for their affinity towards 5-HT1A receptors. The ...