Browsing by Author "201-0020935"

Now showing items 21-24 of 24

    • Oral cancer susceptibility associated with the CYP1A1 and GSTM1 genotypes in Chilean individuals 
      Cordero Torres, Karina Lizzy; Espinoza Santander, Iris; Cáceres Lillo, Dante; Roco, Angela; Miranda Melo, Carla Soledad; Squicciarini Rueda, Valentina; Santander Gallo, Paula Andrea; Kuen Shiou, Lee; Saavedra Saavedra, Iván; Quiñones Sepúlveda, Luis (Spandidos Publications, 2010-05)
      Polycyclic aromatic hydrocarbons (PAHs) contained in tobacco smoke acquire carcinogenicity following their activation by xenobiotic-metabolizing enzymes to highly reactive metabolites. The cytochrome P4501A1 (CYP1A1) enzyme ...
    • Papel de las enzimas citocromo p450 en el metabolismo de fármacos antineoplásicos: Situación actual y ... 
      Quiñones Sepúlveda, Luis; Rosero P., Mario; Roco Arriagada, Angela Margarita; Moreno T., Iván; Sasso Aguirre, Jaime Alfredo; Varela Figueroa, Nelson; Cáceres Lillo, Dante; Saavedra Saavedra, Iván (Sociedad Médica de Santiago, 2008-10)
      Cytochrome P450 enzymes are very important to metabolize anti-carcinogenic agents. Therefore, understanding the role of these enzymes and their allele variants in the bioactivation or detoxification of drugs could greatiy ...
    • Relative bioavailability study with two oral formulations of topiramate using a validated UPLC-MS/MS method 
      Saavedra Saavedra, Iván; Tamayo Carrillo, Evelyn; Gamboa, A.; Sasso Aguirre, Jaime Alfredo; Varela Figueroa, Nelson; Moreno, Iván; Marchant Lavín, Dafne; Cáceres Lillo, Dante; Quiñones Sepúlveda, Luis (2010)
      Changes in bioavailability of anticonvulsant drugs such as topiramate may cause loss of or worsened seizure control. Thus, the purpose of this study was to evaluate, in a double-blind crossover design, the bioavailability ...
    • Variantes polimórficas del citocromo P450 2D6 y su influencia sobre su actividad catalítica debrisoquina ... 
      Garay Cortesi, Joselyn Ivonne (Universidad de ChileCyberDocs, 2012)
      Los médicos prescriben fármacos sobre la base de sus características farmacológicas y sobre la posibilidad de obtener resultados clínicamente reproducibles. Sin embargo, muchos de los fármacos son eficaces en sólo 25% a ...