Browsing by Author "201-0551676"
Now showing items 21-40 of 59
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(Universidad de Chile, 2010)Este estudio fue desarrollado para investigar los mecanismos de reducción y reactividad de una nueva familia 5-Nitroindazoles. Estos compuestos poseen actividad radicalaria a partir de su grupo nitro, razón por la cual son ...
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(Universidad de Chile, 2015)En esta tesis se estudió el comportamiento electroquímico de un grupo de p-naftoquinonas, específicamente, derivados halogenados de arilaminonaftoquinonas, como asimismo, derivados de índoles, furano y quinolinquinonas. ...
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(Universidad de ChileCyberDocs, 2012)
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(Universidad de Chile, 2011)La enfermedad de Chagas, una zoonosis que afecta al continente Americano, es causada por el protozoo flagelado Trypanosoma cruzi y su principal vía de transmisión es vectorial, a través de insectos hematófagos de la ...
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(Bentham Science Publishers B.V., 2017)© 2017 Bentham Science Publishers. Trypanosoma cruzi is the causative agent of Chagas disease. This parasite is vulnerable to the effects of ROS as its main defense mechanism against exogenous agents trypanothione is also ...
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(Bentham Science, 2018)Background: Neglected diseases are becoming more prevalent due to globalization. This has inspired active research in the development of new drugs for the treatment of parasitic diseases such as Chagas disease. Objectives: ...
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(Wiley, 2017-07)ProblemTrypanosoma cruzi and Toxoplasma gondii present, respectively, low and high congenital transmission rates. The placenta as an immune regulatory organ expresses TLRs, leading to the secretion of cytokines. Both ...
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(Springer, 2018)To face the high costs of developing new drugs, researchers in both industry and academy are looking for ways to repurpose old drugs for new uses. In this sense, bisphosphonates that are clinically used for bone diseases ...
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(2009)Previously, we have identified a series of 5-nitroindazoles with good antiprotozoal activities, against Trypanosoma cruzi epimastigotes and Trichomonas vaginalis. Most of them have shown very low unspecific toxicity on ...
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(Frontiers Media S.A., 2018)© 2018 López-Muñoz, Molina-Berríos, Campos-Estrada, Abarca-Sanhueza, Urrutia-Llancaqueo, Peña-Espinoza and Maya. Pathogenic trypanosomatids (Trypanosoma cruzi, Trypanosoma brucei, and Leishmania spp.) are protozoan parasites ...
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(Universidad de Chile, 2007)La enfermedad de Chagas constituye uno de los principales problemas en salud pública en América Latina. Las drogas disponibles en la actualidad para el tratamiento, Nifurtimox y Benznidazol no presentan una respuesta ...
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(Universidad de Chile, 2008)La tripanosomiasis americana o enfermedad de Chagas, producida por el Trypanosoma cruzi, es una de las zoonosis más importantes en América latina. Chile contribuye con aproximadamente 150000 infectados, afectando las seis ...
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(Bentham Science Publishers B.V., 2015)© 2015 Bentham Science Publishers. Tropical parasitic diseases, especially those produced by protozoan parasites, are a major public health problem in many countries, and their impact in the health burden is significant. ...
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(Bentham Science Publishers B.V., 2014)In trypanosomatids, redox homeostasis is centered on trypanothione (N 1,N8-bis(glutathionyl)spermidine, T(SH)2), a low molecular weight thiol that is distinctive for this taxonomic family and not present in the mammalian ...
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(Verlag der Zeitschrift fur Naturforschung, 2013)The extracts of several plants of Central Chile exhibited anti-Trypanosoma cruzi trypomastigotes activity. Most active extracts were those obtained from Podanthus ovatifolius, Berberis microphylla, Kageneckia oblonga, and ...
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(Public Library Science, 2015)Chagas disease is one of the most neglected tropical diseases in the world, affecting nearly 15 million people, primarily in Latin America. Only two drugs are used for the treatment of this disease, nifurtimox and benznidazole. ...
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(Elsevier, 2013)In the search for new therapeutic tools for the treatment of American trypanosomiasis, a series of novel ferrocene and cyrhetrene imine compounds, derived from 5-nitro-heterocycles, were designed, synthesized and ...
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(Elsevier, 2013)Tumor cells present a known metabolic reprogramming, which makes them more susceptible for a selective cellular death by modifying its mitochondrial bioenergetics. Anticancer action of the antioxidant 9,10- dihydroxy-4 ...
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(Elsevier, 2014)Pentamidine is an antiprotozoal and fungicide drug used in the treatment of leishmaniasis and African trypanosomiasis. Despite its extensive use as antiparasitic drug, little evidence exists about the effect of pentamidine ...
