Browsing by Author "3b2bdaf1-bc9f-42d0-9b50-42ce5bc675bb"

Now showing items 21-32 of 32

    • MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of dendritic cells 
      Villablanca, Eduardo J.; Wang, Sen; De Calisto, Jaime; Gomes, Daniel C.O.; Kane, Maureen A.; Napoli, Joseph L.; Blaner, William S.; Kagechika, Hiroyuki; Blomhoff, Rune; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Von Andrian, Ulrich H.; Mora, J. Rodrigo (W.B. Saunders, 2011)
      Background & Aims: Gut-associated dendritic cells (DC) metabolize vitamin A into all-trans retinoic acid (RA), which is required to induce lymphocytes to localize to the gastrointestinal tract and promotes the differentiation ...
    • Neosaxitoxin inhibits the expression of inflammation markers of the M1 Phenotype in macrophages 
      Montero Sepúlveda, María Cecilia; Campo, Miguel del; Bono Merino, María Rosa; Simon Zegers, María Valeska; Guerrero Peralta, Julia; Lagos Wilson, Néstor (MDPI, 2020)
      Background: Neosaxitoxin (NeoSTX) has been used as a local anesthetic, but its anti-inflammatory effects have not been well defined. In the present study, we investigate the effects of NeoSTX on lipopolysaccharide ...
    • Notch Signalling Regulates Cytokine Production by CD8+ and CD4+ T Cells 
      Sauma Mahaluf, Daniela; Ramirez, A.; Alvarez, K.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa (2012)
      The Notch signalling pathway regulates several aspects of cellular differentiation such as T lineage commitment and effector functions on peripheral T cells; however, there is limited information regarding Notch receptor ...
    • P2X7 receptor at the crossroads of T cell fate 
      Rivas Yáñez, Elizabeth; Barrera Ávalos, Carlos; Parra Tello, Brian; Briceño, Pedro F.; Rosemblatt, Mariana V.; Saavedra Almarza, Juan Pablo; Rosemblatt Silber, Mario; Acuña Castillo, Claudio; Bono Merino, María Rosa; Sauma Mahaluf, Daniela (MDPI, 2020)
      The P2X7 receptor is a ligand-gated, cation-selective channel whose main physiological ligand is ATP. P2X7 receptor activation may also be triggered by ARTC2.2-dependent ADP ribosylation in the presence of extracellular ...
    • Pathogen-induced tissue-resident memory T(H)17 (T(RM)17) cells amplify autoimmune kidney disease 
      Krebs, Christian F.; Reimers, Daniel; Zhao, Yu; Paust, Hans-Joachim; Bartsch, Patricia; Núñez, Sarah; Rosemblatt, Mariana V.; Hellmig, Malte; Kilia, Christoph; Borchers, Alina; Enk, León U. B.; Zinke, Michael; Becker, Martina; Schmid, Joanna; Klinge, Stefanie; Wong, Milagros N.; Puelles, Víctor G.; Schmidt, Constatin; Bertram, Tabea; Stumpf, Natascha; Hoxha, Elion; Meyer-Schwesinger, Catherine; Lindenmeyer, Maja T.; Cohen, Clemens D.; Rink, Michael; Kurts, Christian; Franzenburg, Sören; Koch-Nolte, Friedrich; Tur, Jan-Eric; Riedel, Jan Hendrik; Huber, Samuel; Gagliani, Nicola; Huber, Tobias B.; Wiech, Thorsten; Rohde, Holger; Bono Merino, María Rosa; Bonn, Stefan; Panzer, Ulf; Mittrücke, Hans-Willi (American Association Advancement Science, 2020)
      Although it is well established that microbial infections predispose to autoimmune diseases, the underlying mechanisms remain poorly understood. After infection, tissue-resident memory T (T-RM) cells persist in peripheral ...
    • Retinoic Acid as a Modulator of T Cell Immunity 
      Bono Merino, María Rosa; Tejón, Gabriela; Flores Santibáñez, Felipe; Fernández, Dominique; Rosemblatt Silber, Mario César; Sauma Mahaluf, Daniela (MDPI, 2016)
      Vitamin A, a generic designation for an array of organic molecules that includes retinal, retinol and retinoic acid, is an essential nutrient needed in a wide array of aspects including the proper functioning of the visual ...
    • Retinoic acid generates regulatory T cells in experimental transplantation 
      Moore, C.; Fuentes C., Claudio; Sauma Mahaluf, Daniela; Morales, J.; Bono Merino, María Rosa; Rosemblatt Silber, Mario César; Fierro, J. A. (2011)
      Regulatory T cells play a key role to inhibit effector lymphocytes, avoid, autoimmunity, and restrain allogeneic immunity. Retinoic acid is an important cofactor that stimulates the generation and expansion of regulatory ...
    • Role of PD-L2 in B lymphocytes during the development of lupus 
      Hidalgo, Y.; Fuenzalida, M. J.; Rosemblatt Silber, Mario César; Sauma Mahaluf, Daniela; Bono Merino, María Rosa (2016)
    • The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype ... 
      Doñas, Cristian; Carrasco, Macarena; Fritz, Macarena; Ríos del Prado, Carolina Alejandra; Tejón, Gabriela; Osorio Barrios, Francisco; Manríquez, Valeria; Reyes, Paz; Pacheco, Rodrigo; Bono Merino, María Rosa; Loyola, Alejandra; Rosemblatt Silber, Mario César (Academic Press, 2016)
      © 2016 The Authors As it has been established that demethylation of lysine 27 of histone H3 by the lysine-specific demethylase JMJD3 increases immune responses and thus elicits inflammation, we hypothesize that inhibition ...
    • Towards autotrophic tissue engineering: Photosynthetic gene therapy for regeneration 
      Chávez, Myra Noemi; Schenck, Thilo Ludwig; Hopfner, Ursula; Centeno-Cerdas, Carolina; Somlai-Schweiger, Ian; Schwarz, Christian; Machens, Hans Günther; Heikenwalder, Mathias; Bono Merino, María Rosa; Allende Connelly, Miguel; Nickelsen, Jörg; Egaña, José Tomás (Elsevier Ltd, 2016)
      © 2015 Elsevier Ltd. The use of artificial tissues in regenerative medicine is limited due to hypoxia. As a strategy to overcome this drawback, we have shown that photosynthetic biomaterials can produce and provide oxygen ...
    • Transfer of yeast artificial chromosomes into mammalian cells and comparative study of their integrity 
      Gobin, Samuel J.P.; Alcaïde-Loridan, Catherine; Bono Merino, María Rosa; Ottone, Catherine; Chumakov, Ilya; Rothstein, Rodney; Fellous, Marc (1995)
      Yeast artificial chromosomes (YACs) from the CEPH MegaYAC library (Paris, France) ranging in size from 350 to 1600 kb and mapping to the q22.1 and q22.2 regions of human chromosome 21 were transferred into mammalian cells ...
    • Transforming Growth Factor-β and All-Trans Retinoic Acid Generate Ex Vivo Transgenic Regulatory T Cells ... 
      Moore, C.; Sauma Mahaluf, Daniela; Morales, J.; Bono Merino, María Rosa; Rosemblatt Silber, Mario César; Fierro, J. A. (2009)
      CD4+CD25+Foxp3+ regulatory T cells (Treg) mediate immunologic self-tolerance and suppress immune responses. In the gut, a subset of dendritic cells is specialized to induce Treg in a transforming growth factor-β (TGF-β)- ...