Now showing items 21-40 of 56

    • Sepúlveda, S.; Valenzuela, L.; Ponce, I.; Sierra, S.; Bahamondes, P.; Ramirez, S.; Rojas, V.; Kemmerling Weis, Ulrike; Galanti Garrone, Norbel; Cabrera, G. (2014)
      Trypanosoma cruzi is the etiological agent of Chagas disease. The parasite has to overcome oxidative damage by ROS/RNS all along its life cycle to survive and to establish a chronic infection. We propose that T. cruzi is ...
    • Castillo, Christian; Carrillo, Ileana; Libisch, Gabriela; Juiz, Natalia; Gabriel Schijman, Alejandro; Robello, Carlos; Kemmerling Weis, Ulrike (BioMed Central Ltd., 2018)
      © 2018 The Author(s). Background: Chagas disease is caused by Trypanosoma cruzi, a parasite endemic to Latin America. Most infections occur in children by vector or congenital transmission. Trypanosoma cruzi establishes a ...
    • Al-Khan, A.; Aye, I. L.; Barsoum, I.; Borbely, A.; Cebral, E.; Cerchi, G.; Clifton, V. L.; Collins, S.; Cotechini, T.; Davey, A.; Flores Martin, J.; Fournier, T.; Franchi, A. M.; Fretes, R. E.; Graham, C. H.; Godbole, G.; Hansson, S. R.; Headley, P. L.; Ibarra, C.; Jawerbaum, A.; Kemmerling Weis, Ulrike; Kudo, Y.; Lala, P. K.; Lassance, L.; Lewis, R. M.; Menkhorst, E.; Morris, C.; Nobuzane, T.; Ramos, G.; Rote, N.; Saffery, R.; Salafia, C.; Sarr, D.; Schneider, H.; Sibley, C.; Singh, A. T.; Sivasubramaniyam, T. S.; Soares, M. J.; Vaughan, O.; Zamudio, S.; Lash, G. E. (Elsevier, 2011)
      Workshops are an important part of the IFPA annual meeting. At IFPA Meeting 2010 diverse topics were discussed in twelve themed workshops, six of which are summarized in this report. 1. The placental pathology workshop ...
    • Aplin, John D.; Beristain, Alexander; Da Silva Arnold, Sonia; Dunk, Caroline; Duzyj, Christina; Golos, Thaddeus G.; Kemmerling Weis, Ulrike; Knoefler, Martin; Mitchell, Murray D.; Olson, David M.; Petroff, Margaret; Pollheimer, Juergen; Reyes, Leticia; Schedin, Pepper; Soares, Michael J.; Stencel Baerenwald, Jennifer; Thornburg, Kent L.; Lash, Gendie E. (Elsevier, 2017)
      Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialised topics. At IFPA meeting 2016 there were twelve themed workshops, four of which are summarized in this report. These ...
    • Kemmerling Weis, Ulrike; Bosco Becerra, Cleofina; Galanti Garrone, Norbel (Society of Biology of Chile, 2010)
      Chagas' disease is produced by the haemophlagelated protozoan Trypanosoma cruzi and transmitted by haematophages insects such as Triatoma infestans (vinchuca). Due to vector control, congenital transmission gains importance ...
    • Castillo, Christian; Ramírez Toloza, Galia; Valck Calderón, Carolina Eliana; Aguilar, Lorena; Maldonado, Ismael; Rosas, Carlos; Galanti Garrone, Norbel; Kemmerling Weis, Ulrike; Ferreira Vigouroux, Luis Arturo (PLOS Neglected Tropical Diseases, 2013)
      Background: 9 million people are infected with Trypanosoma cruzi in Latin America, plus more than 300,000 in the United States, Canada, Europe, Australia, and Japan. Approximately 30% of infected individuals develop ...
    • Kemmerling Weis, Ulrike; Cabrera, G. F.; Campos, E. O.; Inestrosa, Nibaldo C.; Galanti Garrone, Norbel (WILEY-LISS, 2006-02)
      The nervous system of flatworms is quite simple although there is increasing evidence indicating that it is chemically complex. Studies of the nervous system in these animals have only been performed in the larval stage ...
    • Muñoz, Orlando M.; Maya Arango, Juan; Ferreira, Jorge; Christen, Philippe; San Martín, José; López Muñoz, Rodrigo; Morello Casté, Antonio; Kemmerling Weis, Ulrike (Verlag der Zeitschrift fur Naturforschung, 2013)
      The extracts of several plants of Central Chile exhibited anti-Trypanosoma cruzi trypomastigotes activity. Most active extracts were those obtained from Podanthus ovatifolius, Berberis microphylla, Kageneckia oblonga, and ...
    • Veas Inostroza, Rhonda; Rojas Pirela, Maura; Castillo Rivas, Christian; Olea Azar, Claudio; Moncada, Mauricio; Ulloa, Pablo; Rojas, Verónica; Kemmerling Weis, Ulrike (Elsevier, 2020)
      Introduction: Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, has no effective treatment available. On the other hand, microalgae are aquatic organisms that constitute an interesting reservoir of ...
    • Micaella, Cipriani; Rostan, Santiago; León, Ignacio; Li, Zhu-Hong; Gancheff, Jorge; Kemmerling Weis, Ulrike; Olea Azar, Claudio; Etcheverry, Susana; Docampo, Roberto; Gambino, Dinorah; Otero, Lucía (Springer, 2020)
      Bisphosphonates are the most commonly prescribed drugs for the treatment of osteoporosis and other bone illnesses. Some of them have also shown antiparasitic activity. In search of improving the pharmacological profile of ...
    • Campos Estrada, Carolina; González Herrera, Fabiola; Greif, Gonzalo; Carrillo Werner, Ileana; Guzmán Rivera, Daniela; Liempi Manquel, Ana; Robello, Carlos; Kemmerling Weis, Ulrike; Castillo Rivas, Christian; Maya Arango, Juan Diego (Wiley, 2020)
      Chagas disease is a vector-borne disease caused by the protozoan parasite Trypanosoma cruzi. Current therapy involves benznidazole. Benznidazole and other drugs can modify gene expression patterns, improving the response ...
    • Muñoz Ruz, Ivonne Andrea; Droguett Ossa, Daniel; Donoso Torres, Wendy Karina; Kemmerling Weis, Ulrike; Venegas, Rojas Bernardo Arturo; Rivera, Martínez Cesar Andres (2012)
      This study aimed to examine the role of chronic restraint stress (RS) on oral squamous cell carcinomas induced by 4-nitroquinoline-1-oxide (4-NQO) in CF-1 mouse tongues, measured by the expression of argyrophilic staining ...
    • Díaz Viraque, Florencia; Chiribao, María Laura; Trochine, Andrea; González Herrera, Fabiola; Castillo, Christian; Liempi, Ana; Kemmerling Weis, Ulrike; Diego Maya, Juan; Robello, Carlos (Frontiers media SA, 2018)
      The discovery that trypanosomatids, unicellular organisms of the order Kinetoplastida, are capable of synthesizing prostaglandins raised questions about the role of these molecules during parasitic infections. Multiple ...
    • Rojas Pirela, Maura; Andrade Alviárez, Diego; Rojas, Verónica; Kemmerling, Ulrike; Cáceres, Ana J.; Michels, Paul A.; Concepción, Juan Luis; Quiñones, Wilfredo (Royal Society, 2020)
      Phosphoglycerate kinase (PGK) is a glycolytic enzyme that is well conserved among the three domains of life. PGK is usually a monomeric enzyme of about 45 kDa that catalyses one of the two ATP-producing reactions in the ...
    • Castillo, Christian; Villarroel, Arturo; Duaso, Juan; Galanti Garrone, Norbel; Cabrera Vallejos, Gonzalo; Maya Arango, Juan; Kemmerling Weis, Ulrike (Elsevier, 2013)
      Chagas‘ disease is caused by the haemophlagelated protozoan Trypanosoma cruzi (T. cruzi). During congenital transmission the parasite breaks down the placental barrier, however studies about the physiopathology of this ...
    • Vieites, Marisol; Otero, Lucía; Santos, Diego; Olea Azar, Claudio; Norambuena, Ester; Aguirre, Gabriela; Cerecetto, Hugo; González, Mercedes; Kemmerling Weis, Ulrike; Morello Casté, Antonio; Maya Arango, Juan; Gambino, Dinorah (2009)
      Eight new platinum(II) complexes with 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-trypanosomal activity were synthesized, characterized and in vitro evaluated. Most of the complexes showed IC50 values in the ...
    • Demoro, Bruno; Rossi, Miriam; Caruso, Francesco; Liebowitz, Daniel; Olea Azar, Claudio; Kemmerling Weis, Ulrike; Maya Arango, Juan; Guiset, Helena; Moreno, Virtudes; Pizzo, Chiara; Mahler, Graciela; Otero, Lucía; Gambino, Dinorah (Springer, 2013)
      In the search for new metal-based drugs against diseases produced by trypanosomatid parasites, four organoruthenium(II) compounds [Ru2(p-cymene)2(L)2] X2, where L are bioactive 5-nitrofuryl-containing thiosemicarbazones ...
    • Molina Berríos, Alfredo Enrique; Campos Estrada, Carolina; Lapier, Michel; Duaso, Juan; Kemmerling Weis, Ulrike; Galanti Garrone, Norbel; Ferreira, Jorge; Morello Casté, Antonio; López Muñoz, Rodrigo; Maya Arango, Juan (Springer, 2013)
      Chronic Chagas’ disease affects 10–30 % of patients infected with Trypanosoma cruzi, and it mainly manifests as cardiomyopathy. Important pathophysiological mechanisms involved in the cardiac lesions include activation of ...
    • Molina Berríos, Alfredo Enrique; Campos Estrada, Carolina; Henriquez, Natalia; Faúndez, Mario; Torres, Gloria; Castillo, Christian; Escanilla, Sebastián; Kemmerling Weis, Ulrike; Morello Casté, Antonio; López Muñoz, Rodrigo; Maya Arango, Juan (Public Library of Science, 2013)
      Chagas' disease, produced by Trypanosoma cruzi, affects more than 8 million people, producing approximately 10,000 deaths each year in Latin America. Migration of people from endemic regions to developed countries has ...
    • Castillo, C.; López-Muñoz, R.; Duaso, J.; Galanti Garrone, Norbel; Jaña, F.; Ferreira, J.; Cabrera, G.; Maya Arango, Juan; Kemmerling Weis, Ulrike (2012)
      Background: Chagas' disease is caused by the haemophlagelated protozoan Trypanosoma cruzi (T. cruzi). During congenital transmission the parasite breaks down the placental barrier. In the present study we analyzed the ...