Browsing by Author "6d2f4e64-b3b7-47e0-b560-dbfede86c47c"
Now showing items 21-36 of 36
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Ezquer, Fernando; Quintanilla González, María Elena; Morales, Paola; Santapau, Daniela; Ezquer, Marcelo; Kogan Bocian, Marcelo; Salas Huenuleo, Edison; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Blackwell Publishing Ltd, 2018)© 2018 Society for the Study of AddictionChronic ethanol consumption leads to brain oxidative stress and neuroinflammation, conditions known to potentiate and perpetuate each other. Several studies have shown that ...
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Guivernau, Mauricio; Quintanilla González, María Elena; Tampier de Jong, Lutske (1994)Disulfiram, an aldehyde dehydrogenase (ALDH) inhibitor, induces a flushing reaction upon the ingestion of ethanol, exerting aversion against alcohol that has been used in the treatment of alcoholism. This unpleasant response ...
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Rivera Meza, Mario; Quintanilla González, María Elena; Tampier de Jong, Lutske; Mura, Casilda V.; Sapag, Amalia; Israel Jacard, Yedy (2010)Humans who carry a point mutation in the gene coding for alcohol dehydrogenase-1B (ADH1B*2; Arg47His) are markedly protected against alcoholism. Although this mutation results in a 100-fold increase in enzyme activity, it ...
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Tampier de Jong, Lutske; Cariz, Segundo; Quintanilla González, María Elena (1993)Acetaldehyde (AcH) metabolism in isolated aortic rings was studied by assessing in vitro-added AcH disappearing rate by head space gas chromatography. It was found that AcH was metabolized by aortic rings or by homogenates ...
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Quintanilla González, María Elena; Ezquer, Fernando; Morales Retamales, Paola; Ezquer, Marcelo; Olivares, Belén; Santapau, Daniela; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Frontiers Media, 2020)Chronic ethanol intake results in brain oxidative stress and neuroinflammation, which have been postulated to perpetuate alcohol intake and to induce alcohol relapse. The present study assessed the mechanisms involved in ...
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Quintanilla González, María Elena; Tampier de Jong, Lutske (2011)The main goal of this study was to investigate the ability of an ethanol dose (1. g/kg) administered intraperitoneally to induce conditioned place preference (CPP) and/or conditioned place aversion (CPA) in two lines of ...
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Sapag, Amalia; González Martínez, Ginez Andrés; Lobos González, Lorena; Encina, Gonzalo; Tampier de Jong, Lutske; Israel Jacard, Yedy; Quintanilla González, María Elena (2009)OBJECTIVE: Alcohol is detoxified in the liver by oxidizing enzymes that require nicotinamide adenine dinucleotide (NAD) such that, in the rat, the availability of NAD contributes to control voluntary ethanol intake. The ...
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Quintanilla González, María Elena; Tampier de Jong, Lutske; Sapag, Amalia; Israel Jacard, Yedy (Lippincott Williams & Wilkins, 2005)Dependence on alcohol, a most widely used drug, has a heritability of 50-60%. Wistar-derived rats selectively bred as low-alcohol consumers for many generations present an allele (Aldh22) of mitochondrial aldehyde ...
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Quintanilla González, María Elena; Rivera Meza, Mario; Berríos Cárcamo, Pablo; Cassels Niven, Bruce; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Wiley-Blackwell, 2016)Ethanol is oxidized in the brain to acetaldehyde, which can condense with dopamine to generate (R/S)-salsolinol [(RS)-SAL]. Racemic salsolinol [(RS)-SAL] is self-infused by rats into the posterior ventral tegmental area ...
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Berríos Cárcamo, Pablo; Quintanilla González, María Elena; Herrera-Marschitz Muller, Mario; Vasiliou, Vasilis; Zapata Torres, Gerald; Rivera Meza, Mario (Frontiers Media S.A., 2017)© 2017 Berríos-Cárcamo, Quintanilla, Herrera-Marschitz, Vasiliou, Zapata-Torres and Rivera-Meza. Background: Several studies have shown that the ethanol-derived metabolite salsolinol (SAL) can activate the mesolimbic system, ...
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Quintanilla González, María Elena; Tampier de Jong, Lutske; Karahanian, Eduardo; Rivera Meza, Mario; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (2012-03)Background: In animal models of continuous alcohol self-administration, in which physical dependence does not constitute the major factor of ethanol intake, 2 factors likely contribute to the perpetuation of alcohol ...
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Tampier de Jong, Lutske; Quintanilla González, María Elena (PERGAMON-ELSEVIER SCIENCE LTD, 2005-08)An association between saccharin consumption and alcohol intake has been observed in rodent lines genetically developed for alcohol preference or alcohol avoidance. It has also been proposed that a sweetened alcohol ...
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Quintanilla González, María Elena; Rivera Meza, Mario; Berríos Cárcamo, Pablo; Bustamante, Diego; Buscaglia, Marianne; Morales, Paola; Karahanian, Eduardo; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Elsevier Inc., 2014)© 2014 Elsevier Inc.Salsolinol is formed non-enzymatically when ethanol-derived acetaldehyde binds to dopamine, yielding 2 distinct products, i.e., salsolinol and isosalsolinol. Early animal studies, revealing that salsolinol ...
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Quintanilla González, María Elena; Tampier de Jong, Lutske; Sapag, Amalia; Gerdtzen Hakim, Ziomara; Israel Jacard, Yedy (AMER PHYSIOLOGICAL SOC, 2007-08)Sex differences, alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems perspective. Individuals who carry the most active alcohol dehydrogenase (ADH) isoforms are protected against ...
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Tampier de Jong, Lutske; Zambrano, Veronica; Quintanilla González, María Elena (1990)We have previously reported that UChA rats (genetically low ethanol consumer) develop tolerance to narcosis time easier than UChB rats (genetically high ethanol consumer). We also have reported that UChA rats develop ...
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Quintanilla González, María Elena; Israel Jacard, Yedy; Sapag, Amalia; Tampier de Jong, Lutske (BLACKWELL, 2006-09)Ethanol non-drinker (UChA) and drinker (UChB) rat lines derived from an original Wistar colony have been selectively bred at the University of Chile for over 70 generations. Two main differences between these lines are ...