Browsing by Author "XX631156 "
Now showing items 21-40 of 45
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Bacigalupo Vicuña, Juan; Chinn, Kevin; Lisman, John E. (1986)The light-activated conductance of Limulus ventral photoreceptors was studied using the patch-clamp technique. Channels (40 pS) were observed whose probability of opening was greatly increased by light. In some cells the ...
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Labarca, Pedro; Bacigalupo Vicuña, Juan (Kluwer Academic Publishers-Plenum Publishers, 1988)The olfactory epithelium has the ability to respond to a large number of volatile compounds of small molecular weight. Ultimately, such a property lies on a specialized type of neuron, the olfactory receptor cell. In the ...
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Lopez-Arenas, Estefania; Mackay-Sim, Alan; Bacigalupo Vicuña, Juan; Sulz, Lorena (2012)Neurogenesis continues in the adult brain and in the adult olfactory epithelium. The cytokine, leukaemia inhibitory factor and nitric oxide are both known to stimulate neuronal progenitor cell proliferation in the olfactory ...
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Light-dependent channels from excised patches of Limulus ventral photoreceptors are opened by cGMP Bacigalupo Vicuña, Juan; Johnson, Edwin C.; Vergara Montecinos, Cecilia; Lisman, John E. (National Academy of Sciences, 1991)The identity of the second menenger that directly activates the light-dependent conductance in invertebrate photoreceptors remains unclear; the available evidence provides some support for cGMP and Ca2+. To resolve this ...
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Delgado Arriagada, Ricardo; Delgado, María Graciela; Bastin Héline, Lucie; Glavic Maurer, Álvaro; O'Day, Peter M.; Bacigalupo Vicuña, Juan (Elsevier, 2019)Drosophila phototransduction occurs in light-sensitive microvilli arranged in a longitudinal structure of the photoreceptor, termed the rhabdomere. Rhodopsin (Rh), isomerized by light, couples to G-protein, which activates ...
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Palma, Francisco; Roncagliolo, Pablo; Bacigalupo Vicuña, Juan; Palacios, Adrián (Cambridge University Press, 2001)We investigated the photocurrents from isolated rods of the South American anuran, Caudiverbera caudiverbera. Rod outer segments were on average 66.4 +/ - 11.2 mum (mean +/ - S.D, n = 104) in length and 6.6 +/ - 0.9 ...
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Vera, Jorge; Pereira, Ulises; Reynaert, Bryan; Bacigalupo Vicuña, Juan; Sanhueza Toha, María Magdalena (Pergamon-Elsevier, 2020)Neurons from several brain regions resonate in the theta frequency range (4-12 Hz), displaying a higher voltage response to oscillatory currents at a preferred 'resonant' frequency (f(R)). Subthreshold resonance could ...
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Schmachtenberg, Oliver; Bicker, Gerd; Bacigalupo Vicuña, Juan (Lippincott Williams and Wilkins, 2001)In vertebrate olfactory receptor neurons, NO synthase (NOS) has been detected in embryonic and early postnatal stages. However, expression of the enzyme in the mature epithelium is still controversial. We analyzed the ...
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Schmachtenberg, Oliver; Bacigalupo Vicuña, Juan (Elsevier, 1999)The putative role of nitric oxide (NO) in the physiology of olfactory receptor neurons (ORNs) is controversial. Here we report that pulses of NO caused an outward current in voltage-clamped isolated olfactory neurons. The ...
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Sülz, Lorena; Astorga, Guadalupe; Bellette, Bernadette; Iturriaga, Rodrigo; Mackay Sim, Alan; Bacigalupo Vicuña, Juan (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009-02-05)Nitric oxide regulates neurogenesis in the developing and adult brain. The olfactory epithelium is a site of neurogenesis in the adult and previous studies suggest a role for nitric oxide in this tissue during development. We ...
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Sanhueza Toha, Magdalena; Bacigalupo Vicuña, Juan (1999)Olfactory chemotransduction involves a signaling cascade. In addition to triggering transduction, odors suppress ion conductances. By stimulating with brief odorant pulses, we observed a current associated with odor-induced ...
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Schmachtenberg, Oliver; Bacigalupo Vicuña, Juan (2004)The ciliated receptor neurons of fish olfactory organs are thought to transduce amino acids through a cAMP-dependent transduction pathway, but direct physiological evidence for this hypothesis remains scarce and is confined ...
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Castillo, Karen; Delgado Arriagada, Ricardo; Bacigalupo Vicuña, Juan (BLACKWELL, 2007-09-03)Olfactory sensory neurons respond to odorants increasing Ca2+ concentrations in their chemosensory cilia. Calcium enters the cilia through cAMP-gated channels, activating Ca2+-dependent chloride or potassium channels. ...
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Putative ClC-2 chloride channel mediates inward rectification in Drosophila retinal photoreceptors Ugarte, G.; Delgado Arriagada, Ricardo; O'Day, P.M.; Farjah, F.; Cid, L. P.; Vergara Montecinos, Cecilia; Bacigalupo Vicuña, Juan (SPRINGER, 2005-10)We report that Drosohhila retinal photoreceptors express inwardly rectifying chloride channels that seem to be orthologous to mammalian CIC-2 inward rectifier channels. We measured inwardly rectifying Cl- currents in ...
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Mura, Casilda V.; Delgado Arriagada, Ricardo; Aguirre, Pabla; Bacigalupo Vicuña, Juan; Núñez González, Marco (BLACKWELL PUBLISHING, 2009-01-09)The brain uses massive amounts of oxygen, generating large quantities of reactive oxygen species (ROS). Because of its lipid composition, rich in unsaturated fatty acids, the brain is especially vulnerable to ROS. ...
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Mura, Casilda V.; Delgado Arriagada, Ricardo; Aguirre, Pabla; Bacigalupo Vicuña, Juan; Núñez González, Marco (BLACKWELL, 2006-07)The brain uses massive amounts of oxygen, generating large quantities of reactive oxygen species (ROS). Because of its lipid composition, rich in unsaturated fatty acids, the brain is especially vulnerable to ROS. Furthermore, ...
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Sulz, Lorena; Bacigalupo Vicuña, Juan (SOC BIOLGIA CHILE, 2006)In mammals, neurogenesis continues during adulthood in restricted places of the nervous system, namely the subventricular zone, the dentate gyrus and the olfactory epithelium. A dual role of the second messenger nitric ...
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Saavedra, María Verónica; Smalla, Karl Heinz; Thomas, Ulrich; Sandoval, Soledad; Olavarria, Karel; Castillo, Karen; Delgado, María Graciela; Delgado, Ricardo; Gundelfinger, Eckart D.; Bacigalupo Vicuña, Juan; Wyneken, Ursula (2008)Odour-mediated signal transduction is a complex process that occurs in the cilia of olfactory sensory neurons. To gain insight in to the molecular organization of the odour transduction machinery, we developed a procedure ...
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Delgado Arriagada, Ricardo; Mura, Casilda; Bacigalupo Vicuña, Juan (Biomed Central, 2016)Background: Odor transduction, occurring in the chemosensory cilia of vertebrate olfactory sensory neurons, is triggered by guanosine triphosphate-coupled odor receptors and mediated by a cyclic adenosine monophosphate ...
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Johnson, Edwin C.; Bacigalupo Vicuña, Juan (Springer-Verlag, 1992)We have studied the properties of membrane patches excised from the transducing lobe of Limulus ventral photoreceptors. If patches are excised into an "internal" solution that resembles the ionic composition of the cytoplasm, ...