Browsing by Author "f0295a9b-5595-4e10-8cfe-98f0765104e3"
Now showing items 21-40 of 68
-
Férez, Claudio F.; Marengo, Juan José; Bull Simpfendorfer, Ricardo; Hidalgo Tapia, María Cecilia (1998)Adenosine 5'-cyclic diphosphoribose [cyclic ADP-ribose (cADPR)], a metabolite of NAD+ that promotes Ca2+ release from sea urchin egg homogenates and microsomal fractions, has been proposed to act as an endogenous agonist ...
-
Muñoz, Pablo; Zavala, Gabriela; Castillo, Karen; Aguirre, Pabla; Hidalgo Tapia, María Cecilia; Núñez González, Marco (2006)Recent evidence suggests that reactive oxygen species function as second messenger molecules in normal physiological processes. For example, activation of N-Methyl-D-Aspartate receptor results in the production of ROS, ...
-
Rojas, Eduardo; Hidalgo Tapia, María Cecilia (1968)Labelled Ca `,+ were incorporated into giant axons froln the squid Dosidicus gigas by immersing them in sea water containing 4'5Ca'-' ~. The washout technique was used and two kinetics for 4SCa2+ outflow were demonstrated ...
-
Effects of ATP, Mg2+, and redox agents on the Ca2+ dependence of RyR channels from rat brain cortex Bull Simpfendorfer, Ricardo; Finkelstein, José Pablo; Humeres, Alexis; Behrens Pellegrino, María Isabel; Hidalgo Tapia, María Cecilia (AMER PHYSIOLOGICAL SOC, 2007-07)Despite their relevance for neuronal Ca2+-induced Ca2+ release (CICR), activation by Ca2+ of ryanodine receptor (RyR) channels of brain endoplasmic reticulum at the [ ATP], [Mg2+], and redox conditions present in neurons ...
-
Sánchez, Gina; Escobar, Matías; Pedrozo Cibils, Zully; Macho Fisher, Pilar; Domenech Lira, Raúl; Härtel, Steffen; Hidalgo Tapia, María Cecilia; Donoso Laurent, Paulina (2008)Aim: Our objective was to investigate in cardiac muscle the contribution of NADPH oxidase to (a) ryanodine receptor-2 (RyR2) S-glutathionylation and (b) the preconditioning effects of exercise and tachycardia on infarct ...
-
Beltrán, Marianela; Barrientos, Genaro; Hidalgo Tapia, María Cecilia (SOCIEDAD BIOLOGIA CHILE, 2006)We measured the kinetics of calcium dissociation from calsequestrin in solution or forming part of isolated junctional sarcoplasmic reticulum membranes by mixing calsequestrin equilibrated with calcium with calcium-free ...
-
Llanos Vidal, Paola; Contreras Ferrat, Ariel Eduardo; Barrientos, Genaro; Valencia, Marco; Mears, David; Hidalgo Tapia, María Cecilia (Public Library of Science, 2015)© 2015, Public Library of Science. All rights reserved. This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for ...
-
Riquelme, Denise; Álvarez, Alvaro; Leal, Nancy; Adasme, Tatiana; Espinoza, Italo; Valdés, Juan Antonio; Troncoso, Natalia; Härtel, Steffen; Hidalgo Tapia, Jorge; Hidalgo Tapia, María Cecilia; Carrasco Friz, María Angélica (2011)Neuronal electrical activity increases intracellular Ca2+ concentration and generates reactive oxygen species. Here, we show that high frequency field stimulation of primary hippocampal neurons generated Ca2+ signals with ...
-
Riquelme, Denise; Alvarez, Alvaro; Leal, Nancy; Adasme, Tatiana; Espinoza, Italo; Valdés, Juan Antonio; Troncoso, Natalia; Hartel, Steffen; Segura Hidalgo, Jorge Antonio; Hidalgo Tapia, María Cecilia; Carrasco, M. Angélica (2011)Neuronal electrical activity increases intracellular Ca2+ concentration and generates reactive oxygen species. Here, we show that high frequency field stimulation of primary hippocampal neurons generated Ca 2+ signals with ...
-
Osorio Fuentealba, César; Valdés, Juan Antonio; Riquelme, Denise; Segura Hidalgo, Jorge Antonio; Hidalgo Tapia, María Cecilia; Carrasco, María Angélica (2009)Mammalian cells sense oxygen levels and respond to hypoxic conditions through the regulation of multiple signaling pathways and transcription factors. Here, we investigated the effects of hypoxia on the activity of two ...
-
Aracena Parks, Paula; Goonasekera, Sanjeewa A.; Gilman, Charles P.; Dirksen, Robert T.; Hidalgo Tapia, María Cecilia; Hamilton, Susan L. (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2006-12-29)The skeletal muscle Ca2+-release channel ( ryanodine receptor type 1 (RyR1)) is a redox sensor, susceptible to reversible S-nitrosylation, S-glutathionylation, and disulfide oxidation. So far, Cys-3635 remains the only ...
-
Haeger, Paola; Álvarez, Álvaro; Leal, Nancy; Adasme, Tatiana; Núñez González, Marco; Hidalgo Tapia, María Cecilia (Springer, 2009-08-05)Iron is essential for crucial neuronal functions but is also highly toxic in excess. Neurons acquire iron through transferrin receptor-mediated endocytosis and via the divalent metal transporter 1 (DMT1). The N-terminus (1A, ...
-
Haeger, Paola; Alvarez, Alvaro; Leal, Nancy; Adasme, Tatiana; Núñez González, Marco; Hidalgo Tapia, María Cecilia (2010)Iron is essential for crucial neuronal functions but is also highly toxic in excess. Neurons acquire iron through transferrin receptor-mediated endocytosis and via the divalent metal transporter 1 (DMT1). The N-terminus ...
-
Adasme, Tatiana; Paula Lima, Andrea; Hidalgo Tapia, María Cecilia (Elsevier, 2015)Ryanodine is a cell permeant plant alkaloid that binds selectively and with high affinity to ryanodine receptor (RyR) Ca2þ release channels. Sub-micromolar ryanodine concentrations activate RyR channels while micromolar ...
-
Hidalgo Tapia, María Cecilia; Jaimovich Pérez, Enrique (Kluwer Academic Publishers-Plenum Publishers, 1989)The role of inositol trisphosphate as a chemical messenger in excitation-contraction coupling is discussed, both in terms of positive and negative results. The evidence presented includes experiments on the effect of ...
-
Adasme, Tatiana; Haeger, Paola; Paula Lima, Andrea; Espinoza, Italo; Casas-Alarcón, M. Mercedes; Carrasco Friz, María Angélica; Hidalgo Tapia, María Cecilia (NATL ACAD SCIENCES, 2011-02-15)Ryanodine receptors (RyR)amplify activity-dependent calciuminflux via calcium-induced calcium release. Calcium signals trigger postsynaptic pathways in hippocampal neurons that underlie synaptic plasticity, learning, ...
-
Jaimovich Pérez, Enrique; Donoso Laurent, Paulina; Liberona Leppe, José; Hidalgo Tapia, María Cecilia (Elsevier, 1986)The presence of four cation pathways in membrane vesicles isolated from transverse tubules of frog and rabbit skeletal muscle was studied by measuring binding of specific blockers. Transverse tubules purified from frog ...
-
Muñoz, Juan Pablo; Chiong Lay, Mario; García Nannig, Lorena; Troncoso Cotal, Rodrigo; Toro, Barbra; Pedrozo Cibils, Zully; Díaz Elizondo, Jessica; Salas, Daniela; Parra Ortíz, María Valentina; Núñez González, Marco; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2010-02-15)We investigate here the role of reactive oxygen species and nitric oxide in iron-induced cardiomyocyte hypertrophy or cell death Cultured rat cardiomyocytes incubated with 20 mu M iron (added as FeCl3-Na nitrilotriacetate, ...
-
Bull Simpfendorfer, Ricardo; Finkelstein, José Pablo; Gálvez, Jorge; Sánchez, Gina; Donoso Laurent, Paulina; Behrens Pellegrino, María Isabel; Hidalgo Tapia, María Cecilia (2008)Cerebral ischemia stimulates Ca2+influx and thus increases neuronal intracellular free [Ca2+. Using a rat model of cerebral ischemia without recirculation, we tested whether ischemia enhances the activation by Ca2+ of ...
-
Sánchez, Gina; Hidalgo Tapia, María Cecilia; Donoso Laurent, Paulina (Biophysical Society, 2003)Fast Ca2+ release kinetics were measured in cardiac sarcoplasmic reticulum vesicles actively loaded with Ca2+. Release was induced in solutions containing 1.2 mM free ATP and variable free [Ca2+] and [Mg2+]. Release rate ...