Browsing by Author "Segura Aguilar, Juan"
Now showing items 21-40 of 46
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Segura Aguilar, Juan (Frontiers Media S.A., 2017)
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Copper neurotoxicity in rat substantia Nigra and striatum is dependent on DT-diaphorase inhibition Díaz Véliz, Gabriela; Paris Pizarro, Irmgard; Taiba Mora, Sergio; Raisman Vozari, Rita; Segura Aguilar, Juan (2008)The dependence of copper neurotoxicity on DT-diaphorase inhibition was suggested from results obtained from a cell line derived from substantia nigra. Therefore, the aim of this study was to evaluate whether CuSO4 neurotoxicity ...
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Muñoz, Patricia; Paris Pizarro, Irmgard; Segura Aguilar, Juan (Frontiers Research Foundation, 2016)
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Stuardo Novoa, Cecilia (Universidad de Chile, 2012)La contaminación de cultivos celulares por Mollicutes es frecuente a nivel mundial y muy relevante ya que estas bacterias producen un amplio rango de alteraciones metabólicas y cromosómicas en las células afectadas que ...
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Meléndez, Catalina; Muñoz, Patricia; Segura Aguilar, Juan (Springer, 2019)Aminochrome has been reported to induce lysosomal dysfunction by inhibiting the vacuolar H-type ATPase localized inlysosome membrane. DT-diaphorase has been proposed to prevent aminochrome neurotoxicity but it is unknown ...
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DT-diaphorase protects against autophagy induced by aminochrome dependent alpha synuclein oligomers Muñoz, Patricia S.; Segura Aguilar, Juan (Springer, 2017)Alpha-synuclein (SNCA) oligomers have been reported to inhibit autophagy. Aminochrome-induced SNCA oligomers are neurotoxic, but the flavoenzyme DT-diaphorase prevents both their formation and their neurotoxicity. However, ...
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Paris Pizarro, Irmgard; Pérez Pastene, Carolina; Cárdenas, Sergio; Iturriaga-Vásquez, Patricio; Muñoz, Patricia; Couve, Eduardo; Caviedes, Pablo; Segura Aguilar, Juan (Springer New York LLC, 2010)
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Muñoz, Patricia; Huenchuguala, Sandro; Paris Pizarro, Irmgard; Cuevas, Carlos; Villa, Mónica; Caviedes, Pablo; Segura Aguilar, Juan; Tizabi, Yousef (2012)
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Cárdenas, Ana María; Allen, David D.; Arriagada, Christian; Olivares, Alexis; Bennett, Lori B.; Caviedes, Raúl; Dagnino Subiabre, Alexies; Mendoza, Isabel E.; Segura Aguilar, Juan; Rapoport, Stanley I.; Caviedes, Pablo (2002)We report the establishment of continuously growing cell lines from spinal cords of normal and trisomy 16 fetal mice. We show that both cell lines, named M4b (derived from a normal animal) and MTh (trisomic) possess ...
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Huenchuguala, Sandro; Muñoz, Patricia; Zavala, Patricio; Villa, Mónica; Urriola Cuevas, Carlos; Ahumada, Ulises; Graumann, Rebecca; Nore, Beston F.; Couve, Eduardo; Mannervik, Bengt; Paris Pizarro, Irmgard; Segura Aguilar, Juan (Taylor and Francis Inc., 2014)U373MG cells constitutively express glutathione S-transferase mu 2 (GSTM2) and exhibit 3H-dopamine uptake, which is inhibited by 2 μM of nomifensine and 15 μM of estradiol. We generated a stable cell line (U373MGsiGST6) ...
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Urriola Cuevas, Carlos; Huenchuguala, Sandro; Muñoz, Patricia; Villa, Mónica; Paris Pizarro, Irmgard; Mannervik, Bengt; Segura Aguilar, Juan (Springer, 2015)U373MG cells are able to take up aminochrome that induces glutathione transferase M2-2 (GSTM2) expression in a concentration-dependent manner where 100 A mu M aminochrome increases GSTM2 expression by 2.1-fold (P < 0.001) ...
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Costa, Silvia Lima; Silva, Victor Diogenes Amaral; dos Santos Souza, Cleide; Santos, Cleonice Creusa; Paris Pizarro, Irmgard; Muñoz, Patricia; Segura Aguilar, Juan (Springer New York LLC, 2016)© 2016, Springer Science+Business Media New York.Neurodegenerative disorders have a common characteristic that is the involvement of different cell types, typically the reactivity of astrocytes and microglia, characterizing ...
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Segura Aguilar, Juan; Díaz Véliz, Gabriela; Mora, S.; Herrera-Marschitz Muller, Mario (2002)Intracerebral manganese administration together with the DT-diaphorase inhibitor dicoumarol (Mn3+ 40 nmol+-dicoumarol 2 nmol; in 4 μl) into the left medial forebrain bundle (MFB) produced a behavioural pattern characterised ...
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Zucca, Fabio A.; Segura Aguilar, Juan; Ferrari, Emanuele; Muñoz, Patricia; Paris Pizarro, Irmgard; Sulzer, David; Sarna, Tadeusz; Casella, Luigi; Zecca, Luigi (Elsevier, 2017)There are several interrelated mechanisms involving iron, dopamine, and neuromelanin in neurons. Neuromelanin accumulates during aging and is the catecholamine-derived pigment of the dopamine neurons of the substantia ...
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Cuevas Lizana, Carlos Alberto (Universidad de Chile, 2016)Los astrocitos colaboran con las neuronas en el normal desarrollo de sus actividades metabólicas, y más aún son capaces de participar activamente en su protección frente a estímulos potencialmente dañinos. Se ha demostrado, ...
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Kostrzewa, R. M.; Segura Aguilar, Juan (2002)SNpc neurons are uniquely at risk from damage by a variety of ROS, including catechol-quinones formed from autoxidation of DA; as well as Tyr O, TyrOOH, H2O2O-.2, NO., HONOO-, and HO.. The high content of Fe2+ in SNpc ...
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Segura Aguilar, Juan; Kostrzewa, Richard M. (Springer, 2015)The molecular mechanism responsible for degenerative process in the nigrostriatal dopaminergic system in Parkinson's disease (PD) remains unknown. One major advance in this field has been the discovery of several genes ...
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Segura Aguilar, Juan; Kostrzewa, Richard M. (Springer New York LLC, 2006)Neurotoxlns represent unique chemical tools, providing a means to 1) gain insight into cellular mechanisms of apopotosis and necrosis, 2) achieve a morphological template for studies otherwise unattainable, 3) specifically ...
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Segura Aguilar, Juan (Springer New York LLC, 2018)© 2018, Springer Science+Business Media, LLC, part of Springer Nature.Translational medicine is one of the major concerns in this century. While significant advances have been made with scientific knowledge, the translation ...
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Segura Aguilar, Juan (Academic Press, 2017)