Browsing by Author "201-0010752"

Now showing items 61-70 of 70

    • Synthesis of conformationally restricted N-{4-[4-(4,7-Dimethoxy-Benzo[b]Thiophene-2-Carbonyl)-1-Piperazin ... 
      Pessoa Mahana, Hernán; González Lira, Christian Guillermo; Araya Maturana, Ramiro; Saitz Barría, Claudio; Pessoa, D. (SOC CHILENA QUIMICA, 2009-06)
      New benzothiophene arylpiperazine derivatives 7 (a-1) were synthesized as potential serotoninergic agents with 5-HT1A receptor affinity. Preparation of the derivatives was performed by reaction of 1-(4-aminophenyl)-4-[(4 ...
    • Synthesis of N-(morpholinomethyl) benzamides as moclobemide analogs 
      Pessoa Mahana, Hernán; Astudillo, C. I.; Araya Maturana, Ramiro (MARCEL DEKKER INC, 2002)
      Syntheses of new morpholinomethylbenzamides 6 bearing both electron-withdrawing and electron-releasing groups at the aromatic ring are described. The strategy involved synthesis of hippuric acid ethyl esters 3, their ...
    • Synthesis, docking and pharmacological evaluation of novel homo- and hetero-bis 3-piperazinylpropylindole ... 
      Pessoa Mahana, Hernán; González Lira, Christian; Fierro, Angélica; Zapata Torres, Gerald Amilcar; Pessoa Mahana, Carlos David; Ortiz Severin, Javiera; Iturriaga-Vásquez, Patricio; Reyes Parada, Miguel; Silva Matus, Paul; Saitz Barría, Claudio; Araya Maturana, Ramiro (Elsevier, 2013)
      A series of 3-(3-(4-(3-(1H-indol-3-yl)propyl)piperazin-1-yl)propyl)-1H-indole derivatives (3a–d and 5a– f) as homo- and hetero-bis-ligands, were synthesized and evaluated for in vitro affinity at the serotonin transporter ...
    • Synthesis, Docking Studies and Biological Evaluation of Benzobthiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1-one ... 
      Pessoa Mahana, Hernán; Recabarren Gajardo, Gonzalo Iván; Fiedler Temer, Jenny; Zapata Torres, Gerald Amilcar; Pessoa Mahana, Carlos David; Saitz Barría, Claudio; Araya Maturana, Ramiro (2012)
      A series of novel benzobthiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1-one derivatives 6a–f, 7a–f and their corresponding alcohols 8a–f were synthesized and evaluated for their affinity towards 5-HT1A receptors. The ...
    • Synthesis, Docking, 3-D-Qsar, and Biological Assays of Novel Indole Derivatives Targeting Serotonin ... 
      Cerda Cavieres, Christopher David; Quiroz, Gabriel; Iturriaga-Vásquez, Patricio; Rodríguez Lavado, Julio; Alarcón Espósito, Jazmín; Saitz Barría, Claudio; Pessoa Mahana, Carlos D.; Chung, Hery; Araya Maturana, Ramiro; Mella Raipán, Jaime A.; Cabezas, David; Ojeda Gómez, Claudia; Reyes Parada, Miguel; Pessoa Mahana, Hernán (MDPI, 2020)
      A series of 27 compounds of general structure 2,3-dihydro-benzo[1,4]oxazin-4-yl)-2-{4-[3-(1H-3indolyl)-propyl]-1-piperazinyl}-ethanamides, Series I: 7(a-o) and (2-{4-[3-(1H-3-indolyl)-propyl]-1-piperazinyl}-acetylamine)- ...
    • Synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines ... 
      Rodríguez Lavado, Julio; Gallardo Garrido, Carlos; Mallea Catalán, Michael; Bustos, Víctor; Osorio, Rodrigo; Hödar Salazar, Martín; Chung, Hery; Araya Maturana, Ramiro; Lorca, Marcos; Pessoa Mahana, C. David; Mella Raipán, Jaime; Saitz Barría, Claudio; Jaque Olmedo, Pablo; Reyes Parada, Miguel; Iturriaga-Vásquez, Patricio; Pessoa Mahana, Hernán (Elsevier, 2020)
      During the last decade, the one drug-one target strategy has resulted to be inefficient in facing diseases with complex ethiology like Alzheimer's disease and many others. In this context, the multitarget paradigm has ...
    • The regioselective bromination of 4,4-dimethyl-5,8-dihydroxy-4H-naphthalen-1-one 
      Mejías, Lorenzo; Sepúlveda Boza, Silvia; Araya Maturana, Ramiro; Cassels Niven, Bruce; Caroli Rezende, Marcos (Marcel Dekker, Inc., 1998)
      Methods for the regioselective bromination of the title naphthalenone are described, wich lead to isomeric hydroquinones 5 or 6..
    • Understanding the stereo- and regioselectivities of the polar Diels-Alder reactions between 2-acetyl-1,4- ... 
      Soto Delgado, Jorge; Domingo, L. R.; Araya Maturana, Ramiro; Contreras Ramos, Renato (JOHN WILEY & SONS LTD, 2009-06)
      The polar Diels-Alder (DA) reactions of 2-acetyl-1,4-benzoquinone (acBQ) with methyl substituted 1,3-butadienes have been studied using DFT methods at the B3LYP/6-31 G(d) level of theory. These reactions are characterized ...
    • Use of long-range C-H ((n)J n > 3) heteronuclear multiple bond connectivity in the assignment of the C-13 ... 
      Araya Maturana, Ramiro; Delgado Castro, Tomás; Cardona, Wilson; Weiss López, Boris (BENTHAM SCIENCE PUBL LTD, 2001-03)
      The structural elucidation of complex organic molecules relies heavily on the application of proton detected heteronuclear NMR. Among these techniques, the HMBC NMR experiment is probably the most useful 2D NMR method The ...
    • Very long-range correlations ((n)J(C,H) n > 3) in HMBC spectra 
      Araya Maturana, Ramiro; Pessoa Mahana, Hernán; Weiss López, Boris (NATURAL PRODUCTS INC, 2008)
      The structural elucidation of natural products and complex organic molecules relies heavily on the application of proton detected heteronuclear NMR. Among these techniques, the HMBC NMR experiment remains as the most popular ...