Browsing by Author "be22e20e-f081-465f-908b-dd8a4bb4f2e0"

Now showing items 1-20 of 20

    • Adaptive responses of mitochondria to mild copper deprivation involve changes in morphology, OXPHOS remodeling ... 
      Ruiz, Lina María; Jensen, Erik L.; Bustos, Rodrigo I.; Argüelloa, Graciela; Gutierrez-Garcia, Ricardo; González, Mauricio; Hernández, Claudia; Paredes, Rodolfo; Simon, Felipe; Riedel, Claudia; Ferrick, David; Elorza, Alvaro A. (Wiley-Liss Inc., 2014)
      Copper is an essential cofactor of complex IV of the electron transfer chain, and it is directly involved in the generation of mitochondrial membrane potential. Its deficiency induces the formation of ROS, large mitochondria ...
    • Cavβ2 transcription start site variants modulate calcium handling in newborn rat cardiomyocytes 
      Moreno, Cristian; Hermosilla, Tamara; Morales, Danna; Encina, Matías; Torres-Díaz, Leandro; Díaz, Pablo; Sarmiento, Daniela; Simon, Felipe; Varela, Diego (Springer Verlag, 2015)
      © 2015, Springer-Verlag Berlin Heidelberg.In the heart, the main pathway for calcium influx is mediated by L-type calcium channels, a multi-subunit complex composed of the pore-forming subunit CaV1.2 and the auxiliary ...
    • Chalcone-induced apoptosis through caspase-dependent intrinsic pathways in human hepatocellular carcinoma cells 
      Ramirez-Tagle, Rodrigo; Escobar, Carlos A.; Romero, Valentina; Montorfano, Ignacio; Armisén, Ricardo; Borgna, Vincenzo; Jeldes, Emanuel; Pizarro, Luis; Simon, Felipe; Echeverria, Cesar (MDPI AG, 2016)
      © 2016 by the authors; licensee MDPI, Basel, Switzerland. Hepatocellular carcinoma (HCC) is one of the most commonly diagnosed cancers worldwide. Chemoprevention of HCC can be achieved through the use of natural or synthetic ...
    • Endotoxin-induced vascular endothelial cell migration is dependent on TLR4/NF-κB pathway, NAD(P)H oxidase ... 
      Sarmiento, Daniela; Montorfano, Ignacio; Cáceres, Mónica; Echeverría, César; Fernández, Ricardo; Cabello-Verrugio, Claudio; Cerda, Oscar; Tapia, Pablo; Simon, Felipe (Elsevier Ltd, 2014)
      Endothelial dysfunction is decisive and leads to the development of several inflammatory diseases. Endotoxemia-derived sepsis syndrome exhibits a broad inflammation-induced endothelial dysfunction. We reported previously ...
    • Expression Suppression and Activity Inhibition of TRPM7 Regulate Cytokine Production and Multiple Organ ... 
      Gatica, Sebastian; Eltit, Felipe; Santibanez, Juan F.; Varela, Diego; Cabello-Verrugio, Claudio; Simon, Felipe (NLM (Medline), 2019)
      Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND: Main pathological features detected during sepsis and endotoxemia include over-secretion of pro-inflammatory ...
    • Hydrogen peroxide removes TRPM4 current desensitization conferring increased vulnerability to necrotic cell death 
      Simon, Felipe; Leiva Salcedo, Elías; Armisen Yáñez, Ricardo; Riveros, Ana; Cerda, Oscar; Varela, Diego; Eguiguren, Ana Luisa; Olivero, Pablo; Stutzin Schottlander, Andrés (2010)
      Necrosis is associated with an increase in plasma membrane permeability, cell swelling, and loss of membrane integrity with subsequent release of cytoplasmic constituents. Severe redox imbalance by overproduction of reactive ...
    • Hydroxyl radical activation of a Ca2+-sensitive nonselective cation channel involved in epithelial cell necrosis 
      Simon, Felipe; Varela, Diego; Eguiguren, Ana Luisa; Díaz, Laín F.; Sala, Francisco; Stutzin Schottlander, Andrés (2004)
      In a previous work the involvement of a fenamate-sensitive Ca 2+-activated nonselective cation channel (NSCC) in free radical-induced rat liver cell necrosis was demonstrated (5). Therefore, we studied the effect of radical ...
    • Increased expression of the transient receptor potential melastatin 7 channel is critically involved in ... 
      Núñez-Villena, Felipe; Becerra, Alvaro; Echeverría, Cesar; Briceño, Nicolás; Porras Espinoza, Omar; Armisen Yáñez, Ricardo; Varela, Diego; Montorfano, Ignacio; Sarmiento, Daniela; Simon, Felipe (2011)
      Aims: To assess the mechanisms involved in lipopolysaccharide (LPS)-induced neuronal cell death, we examined the cellular consequences of LPS exposure in differentiated PC12 neurons and primary hippocampal neurons. Results: ...
    • Liquid extracorporeal carbon dioxide removal: use of THAM (tris-hydroxymethyl aminomethane) coupled to ... 
      Tapia, Pablo; Lillo, Felipe; Soto, Dagoberto; Escobar Oregón, Leslie Dominique; Simon, Felipe; Hernández, Karina; Alegría, Leyla; Bruhn, Alejandro (e-Century Publishing Corporation, 2016)
      A promising approach to facilitate protective mechanical ventilation is the use of extracorporeal CO2 removal techniques. Several strategies based on membrane gas exchangers have been developed. However, these techniques ...
    • Non-selective cation channels and oxidative stress-induced cell swelling 
      Simon, Felipe; Varela, Diego; Riveros, Ana; Eguiguren, Ana Luisa; Stutzin Schottlander, Andrés (Society of Biology of Chile, 2002)
      Necrosis is considered as a non-specific form of cell death that induces tissue inflammation and is preceded by cell swelling. This increase in cell volume has been ascribed mainly to defective outward pumping of Na+ caused ...
    • OxHDL controls LOX-1 expression and plasma membrane localization through a mechanism dependent on NOX/ROS/NF-κB ... 
      Pérez, Lorena; Vallejos, Alejandro; Echeverria, Cesar; Varela, Diego; Cabello-Verrugio, Claudio; Simon, Felipe (Nature Publishing Group, 2019)
      © 2019, United States & Canadian Academy of Pathology.Systemic inflammatory diseases enhance circulating oxidative stress levels, which results in the oxidation of circulating high-density lipoprotein (oxHDL). Endothelial ...
    • Prolonged AT(1)R activation induces Ca(V)1.2 channel internalization in rat cardiomyocytes 
      Hermosilla, Tamara; Encina, Matías; Morales, Danna; Moreno, Cristian; Conejeros, Carolina; Alfaro Valdés, Hilda M.; Lagos Meza, Felipe; Simon, Felipe; Altier, Christophe; Varela, Diego (Nature Publishing Group, 2017)
      The cardiac L-type calcium channel is a multi-subunit complex that requires co-assembling of the pore-forming subunit Ca(V)1.2 with auxiliary subunits Ca-V alpha 2 delta and Ca-V beta. Its traffic has been shown to be ...
    • Protective effect of Angiotensin 1–7 on Sarcopenia induced by chronic liver disease in mice 
      Aguirre, Francisco; Abrigo, Johanna; Altimiras González, Francisco; González, Andrea; Simon, Felipe; Cabello Verrugio, Claudio (MDPI, 2020)
      Sarcopenia associated with chronic liver disease (CLD) is one of the more common extrahepatic features in patients with these pathologies. Among the cellular alterations observed in the muscle tissue under CLD is the decline ...
    • Sarcopenia induced by chronic liver disease in mice requires the expression of the bile acids membrane ... 
      Abrigo, Johanna; Campos, Fabián; González, Francisco; Aguirre, Francisco; González, Andrea; Huerta Salgado, Camila; Conejeros, Sabrina; Simon, Felipe; Arrese, Marco; Cabrera, Daniel; Elorza, Alvaro A.; Cabello Verrugio, Claudio (MDPI, 2020)
      Sarcopenia is a condition of muscle dysfunction, commonly associated with chronic liver disease (CLD), characterized by a decline in muscle strength, the activation of the ubiquitin-proteasome system (UPS), and oxidative ...
    • SARS-CoV-2/Renin–angiotensin system: Deciphering the clues for a couple with potentially harmful effects ... 
      González, Andrea; Orozco Aguilar, Josué; Achiardi, Óscar; Simon, Felipe; Cabello Verrugio, Claudio (MDPI, 2020)
      Severe acute respiratory syndrome coronavirus (SARS-CoV-2) has produced significant health emergencies worldwide, resulting in the declaration by the World Health Organization of the coronavirus disease 2019 (COVID-19) ...
    • Suppression of transient receptor potential melastatin 4 expression promotes conversion of endothelial cells ... 
      Echeverría, Cesar; Montorfano, Ignacio; Cabello Verrugio, Claudio; Armisén, Ricardo; Varela, Diego; Simon, Felipe (Lippincott Williams and Wilkins, 2015)
      © 2015 Wolters Kluwer Health | Lippincott Williams & Wilkins.Objective: To study whether transient receptor potential melastatin 4 (TRPM4) participates in endothelial fibrosis and to investigate the underlying mechanism. ...
    • The characterization of anti-T-cruzi activity relationships between ferrocenyl, cyrhetrenyl complexes and ... 
      Echeverría, César; Romero, Valentina; Arancibia, Rodrigo; Klahn, Hugo; Montorfano, Ignacio; Armisen Yáñez, Ricardo; Borgna, Vincenzo; Simon, Felipe; Ramírez Tagle, Rodrigo (Springer, 2016)
      Trypanosoma cruzi (T. cruzi) is the parasite that causes Chagas disease. Nifurtimox is the most used drug against the T. cruzi, this drug increases intermediaries nitro group, being mainly responsible for the high toxicity ...
    • Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death 
      Becerra, Alvaro; Echeverra, Cesar; Varela, Diego; Sarmiento, Daniela; Armisn, Ricardo; Nuez-Villena, Felipe; Montecinos, Mario; Simon, Felipe (2011)
      Aims Endothelial dysfunction is decisive in the progression of cardiovascular diseases. Lipopolysaccharide (LPS)-induced reactive oxygen species (ROS)-mediated endothelial cell death is a main feature observed in inflammation ...
    • TRPM4 enhances cell proliferation through up-regulation of the β-catenin signaling pathway 
      Armisen Yáñez, Ricardo; Marcelain Cubillos, Katherine; Simon, Felipe; Tapia, Julio C.; Toro, Jessica; Quest, Andrew F. G.; Stutzin Schottlander, Andrés (2011)
      Altered expression of some members of the TRP ion channel superfamily has been associated with the development of pathologies like cancer. In particular, TRPM4 levels are reportedly elevated in diffuse large B-cell non-Hodgkin ...
    • TRPV1-Estradiol Stereospecific Relationship Underlies Cell Survival in Oxidative Cell Death 
      Ramírez Barrantes, Ricardo; Carvajal Zamorano, Karina; Rodríguez, Belén; Córdova, Claudio; Lozano, Carlo; Simón, Felipe; Díaz, Paula; Muñoz, Pablo; Marchant, Ivanny; Latorre, Ramón; Castillo, Karen; Olivero, Pablo (Frontiers Media, 2020)
      17 beta-estradiol is a neuronal survival factor against oxidative stress that triggers its protective effect even in the absence of classical estrogen receptors. The polymodal transient receptor potential vanilloid subtype ...