Browsing by Author "c017a729-dc9b-4e52-baec-00a196f9d49d"
Now showing items 1-11 of 11
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Pedemonte, Jaime; Olate, Juan; Cervantes, Paulina; Oberti, Carlos; Gil, Lionel (1981)Administration of 1,2,3-benzothiadiazoles to mice had a biphasic effect on liver microsomal monooxygenases. During the first 15 hr of treatment, an inhibition of the in vivo metabolism of hexobarbital, as well as of the ...
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Biomarkers for screening of lung cancer and pre-neoplastic lesions in a high risk Chilean population Adonis Parraguez, Marta; Díaz, Jose; Miranda, Veronica R.; Chahuan, Marco; Zambrano, Alcides; Benitez, Hugo C.; Campos, Monica; Avaria, Pablo; Urzúa, Ulises; Marín, Pedro; Gohurdett, Mariela; Cisterna, Yasna; Gil, Lionel (socbiol@huelen.reuna.cl, 2014)© 2014 Adonis et al. Background: The mortality of lung cancer (LC), increases each year in the world, in spite of any advances, in development of new drugs to advance stages of LC. The high incidence of LC has been associated ...
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Salazar, Inés; Tarragó-Litvak, Laura; Litvak, Simón; Gil, Lionel (1985)When benzo[a]pyrene (B[a]P) was administered intraperitoneally to rats 48 hr before they were killed, the DNA-synthesizing capability of isolated rat liver nuclei was decreased as compared with control animals. B[a]P also ...
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Ferreira, Jorge; Gil, Lionel; Stutzin Schottlander, Andrés; Orrego, Fernando (1985)Guanethidine at 5-25 mM concentrations was found to induce up to 79% inhibition of ADP-stimulated (state III) oxygen consumption in isolated rat heart, brain or liver mitochondria, when the added substrate was glutamate ...
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Quiñones Sepúlveda, Luis; Berthou, F.; Varela Figueroa, Nelson; Simon, B.; Gil, Lionel; Lucas, D. (Elsevier, 1999)Many investigators have reported an association between genetic polymorphisms of cytochromes P-450 CYP2E1, CYP1A1 or glutathione S-transferase Mu (GSTM1) and susceptibility to lung cancer. However, pronounced interethnic ...
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Caceres, Dante; Adonis Parraguez, Marta; Gil, Lionel; Miguel, A. H. (Elsevier Ltd, 1998)
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Gil, Lionel; Cáceres, Dante; Adonis Parraguez, Marta (S. Karger AG, 1997)The influence of atmospheric pollution on indoor air quality (IAQ) was studied in downtown Santiago (Chile). Carbon monoxide (CO), nicotine, the mass of respirable particulate matter below 5 μm (PM5 fraction) and total and ...
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Capdevila, Jorge; Gil, Lionel; Orellana, Miriam; Marnett, Lawrence J.; Mason, J. Ian; Yadagiri, Pendri; Falck, J. R. (1988)A new generation of heteroatom analogs of arachidonic acid are documented as powerful and selective inhibitors of the cytochrome P-450-dependent arachidonic acid oxygenase reaction (IC50, 5-10 μm) with little effect on ...
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Orellana, Myriam; Valdés, Elena; Capdevila, Jorge; Gil, Lionel (1989)Cytochrome P450-dependent oxidation of arachidonic acid was studied in liver microsomes from normal fed, protein-energy malnourished, and refed rats. The overall rate of arachidonic acid oxidation was very similar in ...
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Gil, Lionel; Vasquez, Hernan; Orellana, Miriam; Selkirk, James; Wold, Finn; Strobel, Henry (Kluwer Academic Publishers, 1988)A liver cytochrome P-450 isozyme has been purified to homogeneity from protein-energy malnourished rats induced with β-naphthoflavone (β-NF). The purification steps included chromatography on DEAE-Sephadex-A-25, DEAE-cellulose ...
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Gil, Lionel; Orellana, Miriam; Mancllla, Jerson; Garcia, Juan; Vasquez, Hernan (1986)An HPLC method described by Mancllla and Gll [Analytical Letters 17,(B9),1984,873-886] has been applied to study the sex dependent expression of several rat liver testosterone hydroxylases. A sample clean up procedure has ...