Browsing by Author "Bravo Sagua, Roberto"

Now showing items 1-18 of 18

    • Acoplamiento espacial entre el retículo endoplásmico y la red mitocondrial durante el estrés de retículo ... 
      Bravo Sagua, Roberto (Universidad de ChileCyberDocs, 2009)
      El estrés en el retículo endoplásmico (RE) genera señales hacia el núcleo y citoplasma, reorganizando la homeostasis proteica e interviniendo en la decisión de vida o muerte celular. A pesar de ser ampliamente estudiada, ...
    • Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state? 
      Peña Oyarzún, Daniel; Bravo Sagua, Roberto; Díaz Vega, Alexis; Aleman, Larissa; Chiong Lay, Mario; García Nannig, Lorena; Bambs, Claudia; Troncoso, Rodrigo; Cifuentes, Mariana; Morselli, Eugenia; Ferreccio, Catterina; Quest, Andrew F. G.; Criollo Céspedes, Alfredo; Lavandero González, Sergio (Elsevier Inc., 2018)
      © 2018 Elsevier Inc. Non-communicable diseases (NCDs), also known as chronic diseases, are long-lasting conditions that affect millions of people around the world. Different factors contribute to their genesis and progression; ...
    • Autophagy mediates calcium-sensing receptor-induced TNFα production in human preadipocytes 
      Mattar, Pamela; Bravo Sagua, Roberto; Tobar, Nicolás; Fuentes, Cecilia; Troncoso, Rodrigo; Breitwieser, Gerda; Lavandero González, Sergio; Cifuentes, Mariana (Elsevier B.V., 2018)
      © 2018 Elsevier B.V. Obesity is a major current public health problem worldwide due to the severe co-morbid conditions that this disease entails. The development of obesity-related cardiometabolic disorders is in direct ...
    • Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER–mitochondria communication during the early phase ... 
      Bravo Sagua, Roberto; Parra, Valentina; Ortiz-Sandoval, Carolina; Navarro Márquez, Mario F.; Rodríguez, Andrea E.; Díaz Valdivia, Natalia; Sanhueza, Carlos; López Crisosto, Camila; Tahbaz, Nasser; Rothermel, Beverly A.; Hill, Joseph A.; Cifuentes, Mariana; Simmen, Thoma (Nature Publishing Group, 2018)
      © 2018, ADMC Associazione Differenziamento e Morte Cellulare. Close contacts between endoplasmic reticulum and mitochondria enable reciprocal Ca2+ exchange, a key mechanism in the regulation of mitochondrial bioenergetics. ...
    • Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy 
      Westermeier, Francisco; Navarro Márquez, Mario F.; López Crisosto, Camila; Bravo Sagua, Roberto; Quiroga Lagos, Clara; Bustamante, Mario; Verdejo, Hugo E.; Zalaquett Sepúlveda, Ricardo; Ibacache, Mauricio; Parra Ortíz, María Valentina; Castro, Pablo F.; Rothermel, Beverly A.; Hill, Joseph A.; Lavandero González, Sergio (Elsevier, 2015)
      Diabetic cardiomyopathy (DCM) is a common consequence of longstanding type 2 diabetes mellitus (T2DM) and encompasses structural, morphological, functional, and metabolic abnormalities in the heart.Myocardial energy metabolism ...
    • Dexamethasone-induced autophagy mediates muscle atrophy through mitochondrial clearance 
      Troncoso, Rodrigo; Paredes, Felipe; Parra, Valentina; Gatica, Damián; Vásquez Trincado, César Alonso; Quiroga, Clara; Bravo Sagua, Roberto; López Crisosto, Camila; Rodriguez, Andrea E.; Oyarzún, Alejandra P.; Kroemer, Guido; Lavandero González, Sergio (Taylor and Francis Inc., 2014)
      Glucocorticoids, such as dexamethasone, enhance protein breakdown via ubiquitin-proteasome system. However, the role of autophagy in organelle and protein turnover in the glucocorticoid-dependent atrophy program remains ...
    • Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics 
      Bravo Sagua, Roberto; Gutiérrez, Tomás; Paredes, Felipe; Gatica, Damián; Rodríguez, Andrea E.; Pedrozo Cibils, Zully; Chiong Lay, Mario; Parra, Valentina; Quest, Andrew F. G.; Rothermel, Beverly A.; Lavandero González, Sergio (Elsevier, 2012)
      Endoplasmic reticulum (ER) stress activates an adaptive unfolded protein response (UPR) that facilitates cellular repair, however, under prolonged ER stress, the UPR can ultimately trigger apoptosis thereby terminating damaged ...
    • ER-to-mitochondria miscommunication and metabolic diseases 
      López Crisosto, Camila; Bravo Sagua, Roberto; Rodríguez Peña, Marcelo; Mera, Claudia; Castro, Pablo F.; Quest, Andrew F. G.; Rothermel, Beverly A.; Cifuentes, Mariana; Lavandero González, Sergio (Elsevier, 2015)
      © 2015 Elsevier B.V.. Eukaryotic cells contain a variety of subcellular organelles, each of which performs unique tasks. Thus follows that in order to coordinate these different intracellular functions, a highly dynamic ...
    • HERPUD1 protects against oxidative stress-induced apoptosis through downregulation of the inositol ... 
      Paredes, Felipe; Parra, Valentina; Torrealba, Natalia; Navarro Márquez, Mario F.; Gatica, Damián; Bravo Sagua, Roberto; Troncoso, Rodrigo; Pennanen, Christian; Quiroga, Clara; Chiong Lay, Mario; Caesar, Christa; Taylor, W. Robert; Molgó, Jordi; San Martín, Alejandra; Jaimovich Pérez, Enrique; Lavandero González, Sergio (Elsevier, 2016)
      Homocysteine-inducible, endoplasmic reticulum (ER) stress-inducible, ubiquitin-like domain member 1 (HERPUD1), an ER resident protein, is upregulated in response to ER stress and Ca2(+) homeostasis deregulation. HERPUD1 ...
    • Mitochondrial dynamics: A potential new therapeutic target for heart failure Dinámica mitocondrial: un ... 
      Kuzmicic, Jovan; Del Campo, Andrea; López Crisosto, Camila; Morales, Pablo E.; Pennanen, Christian; Bravo Sagua, Roberto; Hechenleitner, Jonathan; Zepeda, Ramiro; Castro, Pablo F.; Verdejo, Hugo; Parra, Valentina; Chiong Lay, Mario; Lavandero González, Sergio (2011)
      Mitochondria are dynamic organelles able to vary their morphology between elongated interconnected mitochondrial networks and fragmented disconnected arrays, through events of mitochondrial fusion and fission, respectively. ...
    • Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through ... 
      Del Campo Sfeir, Andrea Estefanía; Parra Ortíz, María Valentina; Vásquez Trincado, César Alonso; Gutiérrez, Tomás; Morales, Pablo E.; López Crisosto, Camila; Bravo Sagua, Roberto; Navarro Márquez, Mario F.; Verdejo, Hugo E.; Contreras Ferrat, Ariel Eduardo; Troncoso Cotal, Rodrigo; Chiong Lay, Mario; Lavandero González, Sergio (American Physiological Society, 2014)
      Insulin is a major regulator of glucose metabolism, stimulating its mitochondrial oxidation in skeletal muscle cells. Mitochondria are dynamic organelles that can undergo structural remodeling in order to cope with these ...
    • Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through ... 
      Del Campo, Andrea; Parra, Valentina; Vásquez Trincado, César Alonso; Gutiérrez, Tomás; Morales, Pablo E.; López Crisosto, Camila; Bravo Sagua, Roberto; Navarro Márquez, Mario F.; Verdejo, Hugo E.; Contreras Ferrat, Ariel Eduardo; Troncoso, Rodrigo; Chiong Lay, Mario; Lavandero González, Sergio (2014)
      Insulin is a major regulator of glucose metabolism, stimulating its mitochondrial oxidation in skeletal muscle cells. Mitochondria are dynamic organelles that can undergo structural remodeling in order to cope with these ...
    • Organelle communication: Signaling crossroads between homeostasis and disease 
      Bravo Sagua, Roberto; Torrealba Cárdenas, Natalia Belén; Paredes, Felipe; Morales, Pablo E.; Pennanen Saavedra, Christian; López Crisosto, Camila; Troncoso Cotal, Rodrigo; Criollo Céspedes, Alfredo; Chiong Lay, Mario; Hill, Joseph A.; Simmend, Thomas; Quest, Andrew F. G.; Lavandero González, Sergio (Elsevier, 2014)
      Cellular organelles do not function as isolated or static units, but rather form dynamic contacts between one another that can be modulated according to cellular needs. The physical interfaces between organelles are ...
    • Prolonged Activation of the Htr2b Serotonin Receptor Impairs Glucose Stimulated Insulin Secretion and ... 
      Cataldo, Luis Rodrigo; Mizgier, María Luisa; Bravo Sagua, Roberto; Jaña, Fabián; Cárdenas, César; Llanos Vidal, Paola; Busso, Dolores; Olmos, Pablo; Galgani Fuentes, José; Santos, José Luis; Cortés, Víctor A. (Public Library of Science, 2017)
      © 2017 Cataldo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
    • Protection of the myocardium against ischemia/reperfusion injury by angiotensin-(1–9) through an AT2R and ... 
      Mendoza Torres, Evelyn; Riquelme, Jaime A.; Vielma, Alejandra; Sagredo, Andrea Ramirez; Gabrielli, Luigi; Bravo Sagua, Roberto; Jalil Milad, Jorge; Rothermel, Beverly A.; Sánchez, Gina; Ocaranza, María Paz; Lavandero González, Sergio (Academic Press, 2018)
      © 2018 Elsevier Ltd Angiotensin-(19), a peptide of the non-classical renin angiotensin system, has been shown to prevent and revert hypertension and cardiac hypertrophy. We hypothetized that systemic delivery of angiotensin-(1–9) ...
    • Regulación de la compartimentalización de la comunicación retículo endoplásmico-mitocondria en la línea ... 
      Bravo Sagua, Roberto (Universidad de Chile, 2015)
      El retículo endoplásmico (RE) y la mitocondria son organelos celulares que entablan una continua y dinámica conversación que permite a la célula responder coordinadamente a diversas situaciones fisiopatológicas. ...
    • Regulation of cardiomyocyte autophagy by calcium 
      Shaikh, Soni; Troncoso Cotal, Rodrigo; Criollo Céspedes, Alfredo; Bravo Sagua, Roberto; García Nannig, Lorena; Morselli, Eugenia; Cifuentes, Mariana; Quest, Andrew F. G.; Hill, Joseph A.; Lavandero González, Sergio (Amer Physiological Soc, 2016)
      Calcium signaling plays a crucial role in a multitude of events within the cardiomyocyte, including cell cycle control, growth, apoptosis, and autophagy. With respect to calcium-dependent regulation of autophagy, ion ...
    • Tumor Suppression and Promotion by Autophagy 
      Ávalos, Yenniffer; Canales, Jimena; Bravo Sagua, Roberto; Criollo Céspedes, Alfredo; Lavandero González, Sergio; Quest, Andrew F. G. (Hindawi, 2014)
      Autophagy is a highly regulated catabolic process that involves lysosomal degradation of proteins and organelles, mostly mitochondria, for the maintenance of cellular homeostasis and reduction of metabolic stress. Problems ...