Now showing items 1-7 of 7

    • Eynaudi Cáceres, Andrea Patricia; Díaz Castro, Francisco; Bórquez, Juan Carlos; Bravo Sagua, Roberto Francisco; Parra Ortiz, Valentina María; Troncoso Cotal, Rodrigo Hernán (Frontiers Media, 2021)
      Fatty acid overload, either of the saturated palmitic acid (PA) or the unsaturated oleic acid (OA), causes triglyceride accumulation into specialized organelles termed lipid droplets (LD). However, only PA overload leads ...
    • López Crisosto, Camila Paz; Díaz Vegas, Alexis; Castro, Pablo F.; Rothermel, Beverly A.; Bravo Sagua, Roberto Francisco; Lavandero González, Sergio Alejandro (SpringerNature, 2021)
      Subcellular organelles communicate with each other to regulate function and coordinate responses to changing cellular conditions. The physical-functional coupling of the endoplasmic reticulum (ER) with mitochondria allows ...
    • Sepúlveda Quiñenao, Claudia Patricia; Rodríguez Silva, José Manuel; Díaz Castro, Francisco; Campo, Andrea del; Bravo Sagua, Roberto Francisco; Troncoso Cotal, Rodrigo Hernán (MDPI, 2022)
      Glucocorticoids (GC) are steroids hormones that drive circulating glucose availability through gluconeogenesis in the liver. However, alternative splicing of the GR mRNA produces two isoforms, termed GR alpha and GR beta. ...
    • Díaz, Paula; Sandoval Bórquez, Alejandra María Loreto; Bravo Sagua, Roberto Francisco; Quest, Andrew Frederick Geoffery; Lavandero González, Sergio Alejandro (Frontiers Media, 2021)
      In recent decades, compelling evidence has emerged showing that organelles are not static structures but rather form a highly dynamic cellular network and exchange information through membrane contact sites. Although ...
    • Díaz Vesga, Magda; Zúñiga Cuevas, Úrsula Almendra; Ramírez Reyes, Andrés Ignacio; Herrera Zelada, Nicolás Gabriel; Palomo, Iván; Bravo Sagua, Roberto Francisco; Riquelme Meléndez, Jaime (Frontiers Media, 2021)
      Despite important advances in the treatment of myocardial infarction that have significantly reduced mortality, there is still an unmet need to limit the infarct size after reperfusion injury in order to prevent the onset ...
    • Bórquez, Juan Carlos; Hidalgo, Miltha; Rodríguez, Juan M.; Montaña, Alejandra; Porras Espinoza, Omar Hugo; Troncoso Cotal, Rodrigo Hernan; Bravo Sagua, Roberto Francisco (Frontiers Media, 2021)
      Sucralose is a non-caloric artificial sweetener widely used in processed foods that reportedly affects energy homeostasis through partially understood mechanisms. Mitochondria are organelles fundamental for cellular ...
    • Morgado Cáceres, Pablo Andrés; Liabeuf Altamirano, Gianella Alejandra; Calle Chalco, Ximena Elena; Briones Suárez, Lautaro Rigoberto Nabi; Riquelme Meléndez, Jaime Andrés; Bravo Sagua, Roberto Francisco; Parra Ortiz, Valentina María (Frontiers Media, 2022)
      The complex physiology of eukaryotic cells requires that a variety of subcellular organelles perform unique tasks, even though they form highly dynamic communication networks. In the case of the endoplasmic reticulum (ER) ...