Browsing by Author "Eltit Ortega, José Miguel"

Now showing items 1-11 of 11

    • A malignant hyperthermia-inducing mutation in RYR1 (R163C): Alterations in Ca2+ entry, release, and retrograde ... 
      Estève, Eric; Eltit Ortega, José Miguel; Bannister, Roger A.; Pessah, Isaac N.; Beam, Kurt G.; Allen, Paul D.; López, José R. (2010)
      Bidirectional signaling between the sarcolemmal L-type Ca2+ channel (1,4-dihydropyridine receptor [DHPR]) and the sarcoplasmic reticulum (SR) Ca2+ release channel (type 1 ryanodine receptor [RYR1]) of skeletal muscle is ...
    • A malignant hyperthermia-inducing mutation in RYR1 (R163C): Consequent alterations in the functional ... 
      Bannister, Roger A.; Estève, Eric; Eltit Ortega, José Miguel; Pessah, Isaac N.; Allen, Paul D.; López, José R.; Beam, Kurt G. (2010)
      Bidirectional communication between the 1,4-dihydropyridine receptor (DHPR) in the plasma membrane and the type 1 ryanodine receptor (RYR1) in the sarcoplasmic reticulum (SR) is responsible for both skeletal-type ...
    • Heart and Skeletal Muscle Are Targets of Dengue Virus Infection 
      Salgado, Doris Martha; Eltit Ortega, José Miguel; Mansfield, Keith; Panqueba, César; Castro, Dolly; Vega, Martha Rocío; Xhaja, Kris; Schmidt, Diane; Martin, Katherine J.; Allen, Paul D.; Rodríguez, Jairo Antonio; Dinsmore, Jonathan H.; López, José Rafael; Bosch, Irene (2010-03)
      Background—Dengue fever is one of the most significant re-emerging tropical diseases, despite our expanding knowledge of the disease, viral tropism is still not known to target heart tissues or muscle. Methods—A prospective ...
    • Hyperosmotic stress activates p65/RelB NF kappa B in cultured cardiomyocytes with dichotomic actions on ... 
      Eisner, Verónica; Quiroga, Clara; Criollo Céspedes, Alfredo; Eltit Ortega, José Miguel; Chiong Lay, Mario; Parra, Valentina; Hidalgo, Karla; Toro, Barbra; Díaz Araya, Guillermo; Lavandero González, Sergio (ELSEVIER, 2006-06-12)
      NF kappa B is a participant in the process whereby cells adapt to stress. We have evaluated the activation of NF kappa B pathway by hyperosmotic stress in cultured cardiomyocytes and its role in the activation of caspase ...
    • IGF-1 regulates apoptosis of cardiac myocyte induced by osmotic-stress 
      Morales, María Paz; Gálvez, Anita; Eltit Ortega, José Miguel; Ocaranza, María Paz; Díaz Araya, Guillermo; Lavandero González, Sergio (ACADEMIC PRESS INC, 2000-04-21)
      Insulin-like growth factor-1 (IGF-1) is a natural protectant of cardiac myocytes that has been shown to improve cardiac function. The role of IGF-1 in attenuating apoptosis induced by osmotic stress (sorbitol, SOR) or by ...
    • Mecanismos moleculares en la apoptosis del cardiomiocito y sus proyecciones patológicas y terapéuticas 
      Maldonado, Carola; Eisner, Verónica; Gálvez, Anita; Ulloa Valenzuela, Juan Alberto; Criollo Céspedes, Alfredo; Ocaranza Osses, Paula; Eltit Ortega, José Miguel; Morales, María Paz; Quiroga Lagos, Clara; Campos Bastidas, Ximena; Chiong Lay, Mario; Sapag Hagar, Mario; Lavandero González, Sergio (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2001)
      La apoptosis junto a la paraptosis y la necrosis constituyen las principales formas de muerte celular conocidas hasta la fecha. La apoptosis se caracteriza por una disminución del volumen celular y formación de "cuerpos ...
    • Membrane electrical activity elicits inositol 1,4,5-trisphosphate-dependent slow Ca2+ signals through a G ... 
      Eltit Ortega, José Miguel; García, Alejandra; Hidalgo Tapia, Jorge; Liberona Leppe, José; Chiong Lay, Mario; Lavandero González, Sergio; Maldonado Maldonado, Edio; Jaimovich Pérez, Enrique (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2006-04-28)
      Tetanic electrical stimulation of myotubes evokes a ryanodine receptor-related fast calcium signal, during the stimulation, followed by a phospholipase C/inositol 1,4,5-trisphosphate-dependent slow calcium signal few seconds ...
    • Membrane electrical activity elicits inositol 1,4,5-trisphosphate-dependent slow Ca2+ signals through a ... 
      Eltit Ortega, José Miguel; García, Alejandra; Hidalgo, Jorge; Liberona, José L.; Chiong Lay, Mario; Lavandero González, Sergio; Maldonado, Edio; Jaimovich Pérez, Enrique (American Society for Biochemistry and Molecular Biology Inc., 2006)
      Tetanic electrical stimulation of myotubes evokes a ryanodine receptor-related fast calcium signal, during the stimulation, followed by a phospholipase C/inositol 1,4,5-trisphosphate-dependent slow calcium signal few seconds ...
    • A rapid and strong apoptotic process is triggered by hyperosmotic stress in cultured rat cardiac myocytes 
      Gálvez, Anita; Morales, María Paz; Eltit Ortega, José Miguel; Ocaranza, María Paz; Carrasco Alarcón, Loreto del Pilar; Campos Bastidas, Ximena; Sapag Hagar, Mario; Díaz Araya, Guillermo; Lavandero González, Sergio (SPRINGER-VERLAG, 2001-05)
      In all cell types, the maintenance of normal cell volume is an essential homeostatic function. Relatively little is known about the induction of apoptosis by hyperosmotic stress and its molecular mechanism in terminally ...
    • RyR1-mediated Ca2+ Leak and Ca2+ Entry Determine Resting Intracellular Ca2+ in Skeletal Myotubes 
      Eltit Ortega, José Miguel; Yang, Tianzhong; Li, Hongli; Molinski, Tadeusz F.; Pessah, Isaac N.; Allen, Paul D.; López, José R. (American Society for Biochemistry and Molecular Biology, Inc., 2010-04-30)
      The control of resting free Ca2+ in skeletal muscle is thought to be a balance of channels, pumps, and exchangers in both the sarcolemma and sarcoplasmic reticulum. We explored these mechanisms using pharmacologic and ...
    • Slow calcium signals after tetanic electrical stimulation in skeletal myotubes 
      Eltit Ortega, José Miguel; Hidalgo Tapia, Jorge; Liberona Leppe, José; Jaimovich Pérez, Enrique (Biophysical Society, 2004-05)
      The fluorescent calcium signal from rat myotubes in culture was monitored after field-stimulation with tetanic protocols. After the calcium signal sensitive to ryanodine and associated to the excitation-contraction coupling, ...