Browsing by Author "Rojas Rivera, Diego"
Now showing items 1-19 of 19
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(2012)Most intrinsic death signals converge into the activation of pro-apoptotic BCL-2 family members BAX and BAK at the mitochondria, resulting in the release of cytochrome c and apoptosome activation. Chronic endoplasmic ...
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(Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2006)Históricamente, la apoptosis y la necrosis han sido consideradas como las dos formas fundamentales de muerte celular. Sin embargo, evidencias recientes sugieren que la muerte celular programada no está confinada sólo a ...
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(CELL PRESS, 2009-03-27)Adaptation to endoplasmic reticulum (ER) stress depends on the activation of an integrated signal transduction pathway known as the unfolded protein response (UPR). Bax inhibitor-1 (BI-1) is an evolutionarily conserved ...
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(2009)Adaptation to endoplasmic reticulum (ER) stress depends on the activation of an integrated signal transduction pathway known as the unfolded protein response (UPR). Bax inhibitor-1 (BI-1) is an evolutionarily conserved ...
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BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response (2011)Both autophagy and apoptosis are tightly regulated processes playing a central role in tissue homeostasis. Bax inhibitor 1 (BI-1) is a highly conserved protein with a dual role in apoptosis and endoplasmic reticulum (ER) ...
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(Elsevier, 2013)tBax Inhibitor-1 (BI-1) is an evolutionarily conserved six-transmembrane domain endoplasmic reticulum(ER)-localized protein that protects against ER stress-induced apoptotic cell death. This function is closelyconnected ...
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(2012)Adaptation to endoplasmic reticulum (ER) stress depends on the activation of the unfolded protein response (UPR) stress sensor inositol-requiring enzyme 1α(IRE1α), which functions as an endoribonuclease that splices the ...
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(American Physiological Society, 2014)Cellular Mechanisms of Endoplasmic Reticulum Stress Signaling in Health and Disease. 1. An overview. Am J Physiol Cell Physiol 307: C582–C594, 2014. First published August 20, 2014; doi:10.1152/ajpcell.00258.2014.—Increased ...
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Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 1. An overview (American Physiological Society, 2014)© 2014 the American Physiological Society. Increased demand on the protein folding capacity of the endoplasmic reticulum (ER) engages an adaptive reaction known as the unfolded protein response (UPR). The UPR regulates ...
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(Impact Journals LLC, 2018)
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(Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2006)El factor de crecimiento análogo a insulina tipo 1 (IGF-1) es un péptido relacionado estructural y funcionalmente con insulina que posee efectos mitogénicos y citoprotectores. Sus efectos biológicos dependen de la activación ...
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(Elsevier, 2011-04)The assembling of distinct signaling protein complexes at the endoplasmic reticulum (ER) membrane controls several stress responses related to calcium homeostasis. autophagy, ER morphogenesis and protein folding. Diverse ...
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(Cell Press, 2018)Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a dynamic signaling network known as the unfolded protein response (UPR). IRE1a is a major UPR transducer, determining cell fate under ER stress. We ...
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(MDPI, 2022)Alzheimer's disease (AD) is the most prevalent age-associated neurodegenerative disease. A decrease in autophagy during aging contributes to brain disorders by accumulating potentially toxic substrates in neurons. Rubicon ...
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(Taylor and Francis Inc., 2014)Pharmacological activation of autophagy is becoming an attractive strategy to induce the selective degradation of aggregate-prone proteins. Recent evidence also suggests that autophagy impairment may underlie the pathogenesis ...
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(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2006-12-01)Cells have developed compensatory mechanisms to restore cell volume, and the ability to resist osmotic swelling or shrinkage parallels their resistance to necrosis or apoptosis. There are several mechanisms by which cells ...
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(Universidad de Chile, 2018)Alteraciones en la homeostasis del retículo endoplasmático (RE) promueven la acumulación de proteínas mal plegadas en su lumen, una condición celular denominada estrés de RE. La adaptación al estrés de RE depende de la ...
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(2012)Transmembrane BAX inhibitor motif-containing (TMBIM)-6, also known as BAX-inhibitor 1 (BI-1), is an anti-apoptotic protein that belongs to a putative family of highly conserved and poorly characterized genes. Here we report ...
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(Universidad de Chile, 2012)La familia de proteínas TMBIM (del inglés TransMembrane Bax-Inhibitor 1 Motive) es altamente conservada y ha sido pobremente caracterizada. Los genes de la familia TMBIM están presente en mamíferos, insectos, plantas y ...
