Browsing by Author "Tampier de Jong, Lutske"
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Quintanilla González, María Elena; Tampier de Jong, Lutske (1995)The acetaldehyde (AcH) oxidizing capacity of total brain homogenates from the genetically high-ethanol consumer (UChB) appeared to be greater than that of the low-ethanol consumer (UChA) rats. To gain further information ...
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Tampier de Jong, Lutske; Sánchez, Eliana; Quintanilla González, María Elena (Carfax Publishing Company, 1996)We have observed that blood acetaldehyde (AcH) levels after an ethanol dose were significantly higher in disulfiram-pre-treated UChA (low ethanol consumer) than in UChB (high ethanol consumer) rats. In order to explore ...
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Quintanilla González, María Elena; Callejas, Orlando; Tampier de Jong, Lutske (2002)We have previously found the existence of a relation between activity of the brain mitochondrial aldehyde dehydrogenase (ALDH2) and consumption of ethanol in rats of the low-alcohol-drinking (UChA) and the high-alcohol-drinking ...
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Tampier de Jong, Lutske; Quintanilla González, María Elena; Contreras, Selfa; Segovia-requelme, Natividad; Mardones, Jorge (1984)This paper is an inventory of some behavioural, biochemical and pharmacological similarities and differences between two inbred strains of Wistar rats differing in voluntary consumption of ethanol, namely: UChA and UChB ...
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Quintanilla González, María Elena; Tampier de Jong, Lutske; Valle-Prieto, Araceli; Sapag, Amalia; Israel Jacard, Yedy (FEDERATION AMER SOC EXP BIOL, 2005-06)Animals selectively bred for a desirable trait retain wanted genes but exclude genes that may counteract the expression of the former. The possible interactions between selected and excluded genes cannot be readily studied ...
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Tampier de Jong, Lutske; Quintanilla González, María Elena (2002)Acute tolerance that develops within minutes of ethanol exposure appears to influence the apparent acute behavioral sensitivity of laboratory animals to ethanol actions. The existence of a correlation between voluntary ...
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Tampier de Jong, Lutske; Valenzuela, Mario; González, Sandra; Cayo, Bernardita; Quintanilla González, María Elena (1997)Rats genetically selected for their different ethanol voluntary consumption, UChA (low consumer) and UChB (high consumer) were used. Naive UChA and UChB rats or submitted to ethanol chronic exposure, received an IP dose ...
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Quintanilla González, María Elena; Sepúlveda, Sandra; Tampier de Jong, Lutske (1993)Acetaldehyde (AcH) levels in blood samples taken from different zones of the vascular system 2 h after a p.o. dose of ethanol (2.76 g/kg) were studied in UChA (low ethanol consumer) and UChB (high ethanol consumer) rats ...
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Tampier de Jong, Lutske; Quintanilla González, María Elena; Mardones, Jorge (1995)Aminotriazole (AT), a catalase inhibitor, was administered to UChA (low ethanol consumer) and UChB (high ethanol consumer) rats. Ethanol, water, and solid food intake were measured during basic, treatment, and posttreatment ...
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Tampier de Jong, Lutske; Quintanilla González, María Elena; Mardones, Jorge (1985)It has previously been reported that the introduction of a new issue (D1) of a stock diet (D0) caused a significant decrease in voluntary ethanol consumption in rats of our UChA (low ethanol consumer) and UChB (high ethanol ...
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Bustamante, Diego; Quintanilla González, María Elena; Tampier de Jong, Lutske; González, Víctor; Israel Jacard, Yedy; Herrera-Marschitz Muller, Mario (ELSEVIER, 2008-09-04)Several studies on the differences between ethanol-preferring versus non-preferring rat lines suggest an innate deficit in the mesolimbic dopaminergic system as an underlying factor for ethanol volition. Rats would try to ...
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Quintanilla González, María Elena; Tampier de Jong, Lutske (1992)The effect of a chronic ethanol consumption by forcing rats to drink a 20% v/v ethanol solution as sole drinking fluid, for 3 months, was evaluated on: liver and brain mitochondrial function, the capacity of isolated ...
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Israel Jacard, Yedy; Rivera Meza, Mario; Karahanian, Eduardo; Quintanilla González, María Elena; Tampier de Jong, Lutske; Morales Retamales, Paola; Herrera-Marschitz Muller, Mario (FRONTIERS RESEARCH FOUNDATION, 2013-07-08)Ethanol is metabolized into acetaldehyde mainly by the action of alcohol dehydrogenase in the liver, while mainly by the action of catalase in the brain. Aldehyde dehydrogenase-2 metabolizes acetaldehyde into acetate in ...
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Ocaranza, Paula; Quintanilla González, María Elena; Tampier de Jong, Lutske; Karahanian, Eduardo; Sapag, Amalia; Israel Jacard, Yedy (2008)Background: Some gene polymorphisms strongly protect against the development of alcoholism. A large proportion of East Asians carry a protective inactivating mutation in aldehyde dehydrogenase (ALDH2*2). These subjects ...
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Tampier de Jong, Lutske; Quintanilla González, María Elena; Mardones, Jorge (1981)The development of tolerance to ethanol was studied in two strains of rats, UChA (low ethanol consumer) and UChB (high ethanol consumer), by the sleeping time test. Marked tolerance (perhaps both metabolic and tissue) ...
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Guivernau, Mauricio; Quintanilla González, María Elena; Tampier de Jong, Lutske (1994)Disulfiram, an aldehyde dehydrogenase (ALDH) inhibitor, induces a flushing reaction upon the ingestion of ethanol, exerting aversion against alcohol that has been used in the treatment of alcoholism. This unpleasant response ...
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Tampier de Jong, Lutske; Cariz, Segundo; Quintanilla González, María Elena (1993)Acetaldehyde (AcH) metabolism in isolated aortic rings was studied by assessing in vitro-added AcH disappearing rate by head space gas chromatography. It was found that AcH was metabolized by aortic rings or by homogenates ...
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Quintanilla González, María Elena; Tampier de Jong, Lutske; Sapag, Amalia; Israel Jacard, Yedy (Lippincott Williams & Wilkins, 2005)Dependence on alcohol, a most widely used drug, has a heritability of 50-60%. Wistar-derived rats selectively bred as low-alcohol consumers for many generations present an allele (Aldh22) of mitochondrial aldehyde ...
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Quintanilla González, María Elena; Tampier de Jong, Lutske; Karahanian, Eduardo; Rivera Meza, Mario; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (2012-03)Background: In animal models of continuous alcohol self-administration, in which physical dependence does not constitute the major factor of ethanol intake, 2 factors likely contribute to the perpetuation of alcohol ...
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Tampier de Jong, Lutske; Quintanilla González, María Elena (2006)An association between saccharin consumption and alcohol intake has been observed in rodent lines genetically developed for alcohol preference or alcohol avoidance. It has also been proposed that a sweetened alcohol solution ...