Browsing by Subject "α-synuclein"

Now showing items 1-3 of 3

    • An ERcentric view of Parkinson's disease 
      Mercado, Gabriela; Valdés, Pamela; Hetz Flores, Claudio (2013)
      Parkinson's disease (PD) is the second most common neurodegenerative disease and is characterized by the selective loss of dopaminergic neurons of the substantia nigra pars compacta and the accumulation of intracellular ...
    • Extracellular alpha-synuclein alters synaptic transmission in brain neurons by perforating the neuronal ... 
      Pacheco, Carla R.; Morales, Camila N.; Ramírez, Alejandra E.; Muñoz, Francisco J.; Gallegos, Scarlet S.; Caviedes, Pablo A.; Aguayo, Luis G.; Opazo, Carlos M. (Blackwell, 2015)
      It has been postulated that the accumulation of extracellular asynuclein (a-syn) might alter the neuronal membrane by formation of ‘pore-like structures’ that will lead to alterations in ionic homeostasis. However, this ...
    • Targeting of the unfolded protein response (UPR) as therapy for Parkinson's disease 
      Martinez, Alexis; Lopez, Nelida; Gonzalez, Constanza; Hetz Flores, Claudio (Wiley-Blackwell Publishing Ltd, 2019)
      Parkinson's disease is the second most common neurodegenerative disorder, leading to the progressive decline of motor control due to the loss of dopaminergic neurons in the substantia nigra pars compacta. At the molecular ...