Browsing by Subject "11β-hydroxysteroid dehydrogenase type 1"

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    • Expression and activity of 11β-hydroxysteroid dehydrogenase type 1 enzyme in subcutaneous and visceral ... 
      Mericq, Verónica; Medina, Pablo; Bouwman, Carolien; Johnson, M. Cecilia; Godoy, Jorge; López, Teresa; Iñíguez Vila, Germán (2009)
      Background: Glucocorticoid excess promotes visceral obesity and cardiovascular disease. Ligand availability to the glucocorticoid receptor is controlled by isoforms of 11β-hydroxysteroid dehydrogenase (11β-HSD) which ...
    • Identification of novel 11β-HSD1 inhibitors by combined ligand- and structure-based virtual screening 
      Lagos, Carlos F.; Vecchiola, Andrea; Allende, Fidel; Fuentes, Cristobal A.; Tichauer, Juan E.; Valdivia, Carolina; Solari, Sandra; Campino, Carmen; Tapia-Castillo, Alejandra; Baudrand, Rene; Villarroel, Pia; Cifuentes, Mariana; Owen, Gareth I.; Carvajal, Cristian A. (2014)
      11 beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts cortisone to cortisol in a NADPH dependent manner. Overexpression of 11β-HSD1 in key metabolic tissues is related to the development of type 2 diabetes, ...