• Identification of novel 11b-HSD1 inhibitors by combined ligand- and structure-based virtual screening 

      Lagos, Carlos F.; Vecchiola, Andrea; Allende, Fidel; Fuentes, Cristobal A.; Valdivia, Carolina; Solari, Sandra; Campino, Carmen; Tapia Castillo, Alejandra; Baudrand, René; Villarroel, Pia; Tichauer, Juan E.; Cifuentes, Mariana; Owen, Gareth I.; Carvajal, Cristian A.; Fardella, Carlos E. (Elsevier, 2014)
      11 beta-hydroxysteroid dehydrogenase type 1 (11b-HSD1) converts cortisone to cortisol in a NADPH dependent manner. Overexpression of 11b-HSD1 in key metabolic tissues is related to the development of type 2 diabetes, ...