Browsing by Subject "Alzheimer’s disease"

Now showing items 1-20 of 26

    • Acute pannexin 1 blockade mitigates early synaptic plasticity defects in a mouse model of Alzheimer's disease 
      Flores Muñoz, Carolina; Gómez, Bárbara; Mery, Elena; Mujica, Paula; Gajardo, Ivana; Córdova, Claudio; López Espíndola, Daniela; Durán Aniotz, Claudia; Hetz Flores, Claudio; Muñoz, Pablo; González Jamett, Arlek; Ardiles, Álvaro (Frontiers Media, 2020)
      Synaptic loss induced by soluble oligomeric forms of the amyloid beta peptide (sA beta os) is one of the earliest events in Alzheimer's disease (AD) and is thought to be the major cause of the cognitive deficits. These ...
    • Alzheimer's Disease-Like Pathology Triggered by Porphyromonas gingivalis in Wild Type Rats Is Serotype Dependent 
      Díaz Zúñiga, Jaime; More, Jamileth Y.; Melgar Rodríguez, Samanta; Jiménez Unión, Matías; Villalobos Orchard, Francisca; Muñoz Manríquez, Constanza; Monasterio, Gustavo; Valdés Guerrero, José; Vernal, Rolando; Paula-Lima, Andrea (Frontiers Media, 2020)
      Periodontal disease is a disease of tooth-supporting tissues. It is a chronic disease with inflammatory nature and infectious etiology produced by a dysbiotic subgingival microbiota that colonizes the gingivodental sulcus. ...
    • Alzheimer’s disease or behavioral variant frontotemporal dementia? Review of key points toward an accurate ... 
      Musa Salech, Gada; Slachevsky Chonchol, Andrea; Muñoz Neira, Carlos; Méndez, Carolina; Villagra Castro, Roque; González Billault, Christian; Ibáñez, Agustín; Hornberger, Michael; Lillo, Patricia (IOS Press, 2020)
      Alzheimer's disease (AD) and frontotemporal dementia (FTD) are the most common neurodegenerative early-onset dementias. Despite the fact that both conditions have a very distinctive clinical pattern, they present with an ...
    • Antioxidant properties of flavonoid metal complexes and their potential inclusion in the development of ... 
      Rodríguez Arce, Esteban Alexander; Saldías, Marianela (Elsevier, 2021)
      The increased oxidative stress in the acceleration of the aging process and development of the neuronal disorder are the common feature detected in neurodegenerative illness, such as Alzheimer’s disease, Parkinson’s ...
    • A beta(1-42) stimulates actin polymerization in hippocampal neurons through Rac1 and Cdc42 Rho GTPases 
      Mendoza Naranjo, Ariadna; González Billault, Christian; Maccioni Baraona, Ricardo (COMPANY OF BIOLOGISTS LTD, 2006-10-30)
      A number of psychiatric and neurodegenerative disorders, such as Alzheimer’s disease, are characterized by abnormalities in the neuronal cytoskeleton. Here, we find that the enhancement in actin polymerization induced ...
    • Docosahexaenoic and arachidonic acids as neuroprotective nutrients throughout the life cycle 
      Sambra Vásquez, Verónica Marcela; Echeverría González, Francisca Cecilia; Valenzuela, Alfonso; Chouinard Watkins, Raphaël; Valenzuela Báez, Rodrigo Wladimir (MDPI, 2021)
      The role of docosahexaenoic acid (DHA) and arachidonic acid (AA) in neurogenesis and brain development throughout the life cycle is fundamental. DHA and AA are long-chain polyunsaturated fatty acids (LCPUFA) vital for ...
    • Dynamin-2 nervous system disorders 
      González Jamett, Arlek M.; Aro Acuña, Valentina; Momboisse, Fanny; Caviedes Fernández, Pablo; Bevilacqua, Jorge; Cárdenas, Ana María (International Society for Neurochemistry, 2014)
      Dynamin-2 is a pleiotropic GTPase whose best-known function is related to membrane scission during vesicle budding from the plasma or Golgi membranes. In the nervous system, dynamin-2 participates in synaptic vesicle ...
    • Evaluating the reliability of neurocognitive biomarkers of neurodegenerative diseases across countries: A ... 
      Bachli, M. Belén; Sedeño, Lucas; Ochab, Jeremi K; Piguet, Olivier; Kumfor, Fiona; Reyes, Pablo; Torralva, Teresa; Roca, María; Cardona, Juan Felipe; González Campo, Cecilia; Herrera, Eduar; Slachevsky Chonchol, Andrea; Matallana, Diana; Manes, Facundo; García, Adolfo M.; Ibáñez, Agustín; Chialvo, Dante R. (Elsevier, 2020)
      Accurate early diagnosis of neurodegenerative diseases represents a growing challenge for current clinical practice. Promisingly, current tools can be complemented by computational decision-support methods to objectively ...
    • Glucose metabolism and AD: evidence for a potential diabetes type 3 
      González, Andrea; Calfio Painemal, Camila Del Pilar; Churruca, Macarena; Maccioni Baraona, Ricardo Benjamin (BMC, 2022)
      Background Alzheimer's disease is the most prevalent cause of dementia in the elderly. Neuronal death and synaptic dysfunctions are considered the main hallmarks of this disease. The latter could be directly associated to ...
    • Imaging biomarkers in neurodegeneration: current and future practices 
      Young, Peter N. E.; Estarellas, Mar; Coomans, Emma; Srikrishna, Meera; Beaumont, Helen; Maass, Anne; Venkataraman, Ashwin V.; Lissaman, Rikki; Jiménez Fernández, Daniel; Betts, Matthew J.; McGlinchey, Eimear; Berron, David; O’Connor, Antoinette; Fox, Nick c.; Pereira, Joana B.; Jagust, William; Carter, Stephen F.; Paterson, Ross W.; Schöll, Michael (BMC, 2020)
      There is an increasing role for biological markers (biomarkers) in the understanding and diagnosis of neurodegenerative disorders. The application of imaging biomarkers specifically for the in vivo investigation of ...
    • Inflaming the brain with iron 
      Urrutia Vargas, Pamela Joselyn; Bórquez, Daniel A.; Núñez González, Marco Tulio (MDPI, 2021)
      Iron accumulation and neuroinflammation are pathological conditions found in several neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). Iron and inflammation are intertwined in a ...
    • Interoception primes emotional processing: Multimodal evidence from neurodegeneration 
      Salamone, Paula C.; Legaz, Agustina; Sedeño, Lucas; Moguilner, Sebastián; Fraile Vázquez, Matías; González Campo, Cecilia; Fittipaldi, Sol; Yoris, Adrián; Miranda, Magdalena; Birba, Agustina; Galiani, Agostina; Abrevaya, Sofía; Neely Prado, Alejandra; Martorell Caro, Miguel; Alifano, Florencia; Villagra Castro, Roque Ariel; Anunziata, Florencia; Okada de Oliveira, Maira; Pautassi, Ricardo M.; Slachevsky Chonchol, Andrea Maria; Serrano, Cecilia; García, Adolfo M.; Ibañez, Agustín (Soc Neuroscience, 2021)
      Recent frameworks in cognitive neuroscience and behavioral neurology underscore interoceptive priors as core modulators of negative emotions. However, the field lacks experimental designs manipulating the priming of ...
    • Mapping the neuroanatomy of functional decline in Alzheimer’s disease from basic to advanced activities of ... 
      Slachevsky Chonchol, Andrea; Forno, Gonzalo; Barraza, Paulo; Mioshi, Eneida; Delgado, Carolina; Lillo, Patricia; Henríquez, Fernando; Bravo, Eduardo; Farías, Mauricio; Muñoz Neira, Carlos; Ibáñez, Agustín; Parra, Mario A.; Hornberger, Michael (Dr. Dietrich Steinkopff Verlag GmbH and Co. KG, 2019)
      Background: Impairments in activities of daily living (ADL) are a criterion for Alzheimer’s disease (AD) dementia. However, ADL gradually decline in AD, impacting on advanced (a-ADL, complex interpersonal or social ...
    • Plasma Tau Variants Detected by a Novel Anti-Tau Monoclonal Antibody: A Potential Biomarker for Alzheimer’s Disease 
      González, Andrea; Guzmán Martínez, Leonardo; Maccioni Baraona, Ricardo (IOP Publishing, 2020)
      Background: A major drawback in Alzheimer's disease (AD) is the lack of validated biomarkers for routine clinical diagnostic. We have reported earlier a novel blood biomarker, named Alz-tau (R), based on variants of platelet ...
    • Plasmonic nanoparticles as optical sensing probes for the detection of alzheimer’s disease 
      Oyarzún, María Paz; Tapia Arellano, Andreas; Cabrera, Pablo; Jara Guajardo, Pedro; Kogan, Marcelo J. (MDPI, 2021)
      Alzheimer’s disease (AD), considered a common type of dementia, is mainly characterized by a progressive loss of memory and cognitive functions. Although its cause is multifactorial, it has been associated with the ...
    • The Role of Neuroimmunomodulation in Alzheimer's Disease 
      Maccioni Baraona, Ricardo; Rojo, Leonel; Fernández, Jorge A.; Kuljis, Rodrigo O. (BLACKWELL, 2009)
      The idea that alterations in the brain immunomodulation are critical for Alzheimer’s disease (AD) pathogenesis provides the most integrative view on this cognitive disorder, considering that converging research lines ...
    • RyR2-mediated Ca2+ release and mitochondrial ROS generation partake in the synaptic dysfunction caused by ... 
      San Martín Rovirosa, Carol; Veloso, Pablo; Adasme, Tatiana; Lobos, Pedro; Bruna, Barbara; Galaz, Jose; García, Alejandra; Hartel, Steffen; Hidalgo Tapia, María Cecilia; Paula Lima, Andrea (Frontiers Research Foundation, 2017)
      © 2017 SanMartín, Veloso, Adasme, Lobos, Bruna, Galaz, García, Hartel, Hidalgo and Paula-Lima. Amyloid β peptide oligomers (AβOs), toxic aggregates with pivotal roles in Alzheimer’s disease, trigger persistent and low ...
    • Senescence markers in peripheral blood mononuclear cells in amnestic mild cognitive impairment and alzheimer’s ... 
      Salech Morales, Felipe Humberto; San Martín Rovirosa, Carol Dazil; Concha Cerda, Jorge Ignacio; Romero Hernández, Esteban Ignacio; Ponce, Daniela P.; Liabeuf Altamirano, Gianella Alejandra; Rogers Castillo, Nicole Andrea; Murgas, Paola; Bruna, Bárbara; More, Jamileth; Behrens Pellegrino, María Isabel (MDPI, 2022)
      Recent studies suggest that cellular senescence plays a role in Alzheimer’s Disease (AD) pathogenesis. We hypothesize that cellular senescence markers might be tracked in the peripheral tissues of AD patients. Senescence ...
    • Small-molecule aggregation inhibitors reduce excess amyloid in a trisomy 16 mouse cortical cell line 
      Paula Lima, Andrea; Arriagada Abarzúa, Christian; Toro Sánchez, Rodrigo; Cárdenas, Ana María; Caviedes Codelia, Raúl; Ferreira, Sergio T.; Caviedes Fernández, Pablo (SOC BIOLGIA CHILE, 2008)
      We have previously characterized a number of small molecule organic compounds that prevent the aggregation of the β-amyloid peptide and its neurotoxicity in hippocampal neuronal cultures. We have now evaluated the effects ...
    • Synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines ... 
      Rodríguez Lavado, Julio; Gallardo Garrido, Carlos; Mallea Catalán, Michael; Bustos, Víctor; Osorio, Rodrigo; Hödar Salazar, Martín; Chung, Hery; Araya Maturana, Ramiro; Lorca, Marcos; Pessoa Mahana, C. David; Mella Raipán, Jaime; Saitz Barría, Claudio; Jaque Olmedo, Pablo; Reyes Parada, Miguel; Iturriaga-Vásquez, Patricio; Pessoa Mahana, Hernán (Elsevier, 2020)
      During the last decade, the one drug-one target strategy has resulted to be inefficient in facing diseases with complex ethiology like Alzheimer's disease and many others. In this context, the multitarget paradigm has ...