Browsing by Subject "Clinical trial"

Now showing items 1-20 of 31

    • A comparison of the effects of the selective peripheral α1-blocker terazosin with the selective β1-blocker ... 
      Ligueros, M.; Unwin, R.; Wilkins, M. R.; Humphreys, J.; Coles, S. J.; Cleland, J. (Springer-Verlag, 1992)
      The effects of six weeks of treatment with the selective peripheral α1-adrenoceptor blocker terazosin, or the selective β1-adrenoceptor blocker atenolol on blood pressure, exercise performance and blood lipid profile were ...
    • A first in human trial implanting microalgae shows safety of photosynthetic therapy for the effective ... 
      Obaid Bobadilla, Miguel Luis; Camacho, Juan Pablo; Brenet, Marianne; Corrales Orovio, Rocío; Carvajal, Felipe; Martorell, Ximena; Werner, Consuelo; Simón, Valeska; Varas, Juan; Calderón Ortega, Wilfredo Luis; Guzmán, Christian Dani; Bono Merino, María Rosa; San Martín, Sebastián; Eblen Zajjur, Antonio; Egana, José Tomas (Frontiers Media, 2021)
      Insufficient oxygen supply represents a relevant issue in several fields of human physiology and medicine. It has been suggested that the implantation of photosynthetic cells can provide oxygen to tissues in the absence ...
    • A novel approach for in-office tooth bleaching with 6 % H2O2/TiO_N and LED/laser system—a controlled, ... 
      Freitas Bortolatto, Janaina; Trevisan, Tamara Carolina; Ismael Bernardi, Priscila; Fernández Godoy, Eduardo; Nordi Dovigo, Livia; Dourado Loguercio, Alessandro; Batista de Oliveira Junior, Osmir; Pretel, Hermes (Springer London, 2016)
      The purpose of this randomized, parallel, tripleblinded clinical trial was to compare efficacy and tooth sensitivity (TS) after use of an in-office bleaching agent of 6 % hydrogen peroxide containing nanoparticles of ...
    • Antibiotic prophylaxis for preventing infectious complications in orthognathic surgery 
      Brignardello Petersen, Romina; Carrasco Labra, Alonso; Araya, Ignacio; Yanine, Nicolás; Córdova Jara, Luis; Villanueva Maffei, Julio (Wiley & Sons, 2015)
      Background Orthognathic surgery (OS) is a term that refers to many elective surgical techniques to correct facial deformity; the associated malocclusion and functional disorders related to the stomatognathic system. ...
    • Can repair increase the longevity of composite resins? Results of a 10-year clinical trial 
      Fernández Godoy, Eduardo; Martín Casielles, Javier; Vildósola Grez, Patricio; Oliveira, Osmir Batista; Gordan, V.; Mjor, I.; Bersezio Miranda, Cristian; Estay Larenas, Juan; De Andrade, M.; Moncada, G. (Elsevier, 2015)
      Objectives: The aim of this double-blind clinical trial was to assess the longevity of repairs to localized clinical defects in composite resin restorations that were initially planned to be treated with a restoration ...
    • Cardiac pharmacological preconditioning associated with omega 3 supplementation: Potential clinical applications 
      Castillo, Rodrigo L. (Nova Science Publishers, Inc., 2017)
      © 2017 Nova Science Publishers, Inc. Hypoxia is a pathophysiological condition associated with several responses at the cardiovascular, pulmonary and vascular levels, which may develop into chronic diseases. This is relevant ...
    • Clinical prediction algorithm (BRAIN) to determine risk of hematoma growth in acute intracerebral hemorrhage 
      Wang, Xia; Arima, Hisatomi; Al-Shahi Salman, Rustam; Woodward, Mark; Heeley, Emma; Stapf, Christian; Lavados Germain, Pablo Manuel; Robinson, Thompson; Huang, Yining; Wang, Jiguang; Delcourt, Candice; Anderson, Craig S. (Lippincott Williams and Wilkins, 2015)
      Background and Purpose—We developed and validated a simple algorithm to predict the risk of hematoma growth in acute spontaneous intracerebral hemorrhage (ICH) to better inform clinicians and researchers in their efforts ...
    • Core outcome measures for trials in people with coronavirus disease 2019: respiratory failure, multiorgan ... 
      Tong, Allison; Baumgart, Amanda; Evangelidis, Nicole; Viecelli, Andrea K.; Carter, Simón A.; Azevedo, Luciano Cesar; Cooper, Tess; Bersten, Andrew; Cervantes, Lilia; Chew, Derek P.; Crowe, Sally; Douglas, Ivor S.; Flemyng, Ella; Elliott, Julián H.; Hannan, Elyssa; Horby, Peter; Howell, Martín; Ju, Angela; Lee, Jaehee; Lorca Herrera, Eduardo Ignacio; Lynch, Deena; Manera, Karine E.; Marshall, John C.; Matus González, Andrea; McKenzie, Anne; Mehta, Sangeeta; Mer, Mervyn; Conway Morris, Andrew; Needham, Dale M.; Nseir, Saad; Povoa, Pedro; Reid, Mark; Sakr, Yasser; Shen, Ning; Smyth, Alan R.; Simpson, A. John; Snelling, Tom; Strippoli, Giovanni F. M.; Teixeira Pinto, Armando; Torres, Antoni; Turner, Tari; Webb, Steve; Williamson, Paula R.; Woc Colburn, Laila; Zhang, Junhua; Craig, Jonathan C. (Lippincott Williams & Wilkins, 2021)
      OBJECTIVES: Respiratory failure, multiple organ failure, shortness of breath, recovery, and mortality have been identified as critically important core outcomes by more than 9300 patients, health professionals, and ...
    • Core outcomes set for trials in people with coronavirus disease 2019 
      Tong, Allison; Elliott, Julián H.; Azevedo, Luciano César; Baumgart, Amanda; Bersten, Andrew; Cervantes, Lilia; Chew, Derek P.; Cho, Yeoungjee; Cooper, Tess; Crowe, Sally; Douglas, Ivor S.; Evangelidis, Nicole; Flemyng, Ella; Hannan, Elyssa; Horby, Peter; Howel, Martin; Lee, Jaehee; Liu, Emma; Lorca, Eduardo; Lynch, Deena; Marshall, John C.; Matus González, Andrea; McKenzie, Anne; Manera, Karine E.; McLeod, Charlie; Mehta, Sangeeta; Mer, Mervyn; Morris, Andrew Conway; Nseir, Saad; Povoa, Pedro; Reid, Mark; Sakr, Yasser; Shen, Ning; Smyth, Alan R.; Snelling, Tom; Strippoli, Giovanni F. M.; Teixeira Pinto, Armando; Torres, Antoni; Turner, Tari; Viecelli, Andrea K.; Webb, Steve; Williamson, Paula R.; Woc-Colburn, Laila; Zhang, Junhua; Craig, Jonathan C. (Lippincott Williams & Wilkins, 2020)
      Objectives: The outcomes reported in trials in coronavirus disease 2019 are extremely heterogeneous and of uncertain patient relevance, limiting their applicability for clinical decision-making. The aim of this workshop ...
    • Demographic and HIV-specific characteristics of participants enrolled in the INSIGHT Strategic Timing of ... 
      Sharma, S.; Babiker, A.G.; Emery, S.; Gordin, F.M.; Lundgren, J.D.; Neaton, J.N.; Bakowska, E.; Schechter, M.; Wiselka, M.J.; Wolff Reyes, Marcelo (British HIV Association, 2015)
      Objectives The risks and benefits of initiating antiretroviral treatment (ART) at high CD4 cell counts have not been reliably quantified. The Strategic Timing of AntiRetroviral Treatment (START) study is a randomized ...
    • Dysphagia screening and risks of pneumonia and adverse outcomes after acute stroke: An international ... 
      Ouyang, Menglu; Boaden, Elizabeth; Arima, Hisatomi; Lavados Germain, Pablo Manuel; Billot, Laurent; Hackett, Maree L.; Olavarría, Verónica V.; Muñoz Venturelli, Paula; Song, Lili; Rogers, Kris; Middleton, Sandy; Pontes Neto, Octavio M.; Lee, Tsong Hai; Watkins, Caroline; Robinson, Thompson; Anderson, Craig S. (SAGE, 2019)
      Background: Dysphagia is associated with aspiration pneumonia after stroke. Data are limited on the influences of dysphagia screen and assessment in clinical practice. Aims: To determine associations between a “brief” ...
    • Early implant placement with or without alveolar ridge preservation in single tooth gaps renders similar ... 
      Jonker, Brend P.; Strauss Avendaño, Franz Josef; Naenni, Nadja; Jung, Ronald E.; Wolvius, Eppo B.; Pijpe, Justin (Wiley, 2021)
      Objectives: To test whether early implant placement with alveolar ridge preservation (ARP) results in different esthetic, clinical and patient-reported outcome measures (PROMs) compared with early implant placement ...
    • Effectiveness of a normative nutrition intervention in Chilean pregnant women on maternal and neonatal ... 
      Garmendia Miguel, María Luisa; Corvalán Aguilar, Camila; Araya, Marcela; Casanello, Paola; Kusanovic, Juan Pedro; Uauy Dagach-Imbarack, Ricardo (Oxford, 2020)
      Background: Some nutritional interventions have shown their efficacy in reducing gestational weight gain (GWG); however, their applicability in routine care is limited. Objective: We assessed the effectiveness of a ...
    • Effects of an avocado-based mediterranean diet on serum lipids for secondary prevention after ischemic ... 
      Olivarría, Verónica V.; Campodónico, Paola; Vollrath, Valeska; Von Geldern, Paula; Velásquez, Carolina; Pavez, Patricia; Valente, Bárbara; Donoso, Pamela; Ginesta Frings, Carmen Alexandra; Cavada, Gabriel; Mazzon, Enrico; Navia, Víctor; Guzmán, Matías; Brinck, Pablo; Lavados, Pablo M. (Lippincott Williams & Wilkins, 2021)
      Background: A poor or unhealthy diet is responsible for an important fraction of ischemic stroke risk. Adherence to dietary patterns, such as the Mediterranean diet, rich in monounsaturated fatty acids mainly from olive ...
    • Implementation tells us more beyond pooled estimates: Secondary analysis of a multicountry mhealth trial ... 
      Carrillo-Larco, Rodrigo M.; Jiwani, Safia S.; Diez-Canseco, Francisco; Kanter, Rebecca; Beratarrechea, Andrea; Irazola, Vilma; Ramirez-Zea, Manuel; Rubinstein, Adolfo; Martinez, Homero; Miranda, J. Jaime (Journal of Medical Internet Research, 2018)
      ©Rodrigo M Carrillo-Larco, Safia S Jiwani, Francisco Diez-Canseco, Rebecca Kanter, Andrea Beratarrechea, Vilma Irazola, Manuel Ramirez-Zea, Adolfo Rubinstein, Homero Martinez, J Jaime Miranda, GISMAL Group. Background: The ...
    • International survey to establish prioritized outcomes for trials in people with Coronavirus disease 2019 
      Evangelidis, Nicole; Tong, Allison; Howell, Martín; Teixeira Pinto, Armando; Elliott, Julián H.; Azevedo, Luciano César; Bersten, Andrew; Cervantes, Lilia; Chew, Derek P.; Crowe, Sally; Douglas, Ivor S.; Flemyng, Ella; Horby, Peter; Lee, Jaehee; Lorca, Eduardo; Lynch, Deena; Marshall, John C.; McKenzie, Anne; Mehta, Sangeeta; Mer, Mervyn; Morris, Andrew Conway; Nseir, Saad; Povoa, Pedro; Reid, Mark; Sakr, Yasser; Shen, Ning; Smyth, Alan R.; Snelling, Tom; Strippoli, Giovanni F. M.; Torres, Antoni; Turner, Tari; Webb, Steve; Williamson, Paula R.; Woc-Colburn, Laila; Zhang, Junhua; Baumgart, Amanda; Cabrera, Sebastián; Cho, Yeoungjee; Cooper, Tess; Guha, Chandana; Liu, Emma; Matus González, Andrea; McLeod, Charlie; Natale, Patrizia; Saglimbene, Valeria; Viecelli, Andrea K.; Craig, Jonathan C. (Lippincott Williams & Wilkins, 2020)
      Objectives: There are over 4,000 trials conducted in people with coronavirus disease 2019. However, the variability of outcomes and the omission of patient-centered outcomes may diminish the impact of these trials on ...
    • Long-term performance of refurbished amalgam restorations: 10-year follow-up 
      Moncada, Gustavo; Fernández Godoy, Eduardo; Mena, Katherine; Vildósola Grez, Patricio; Estay, Juan; Oliveira, Osmir; Martin, Javier; Mjör, Ivar; Gordan, Valeria (Quintessence Publishing Co., Ltd, 2016)
      Purpose: This prospective, blinded clinical trial assessed the performance of amalgam restorations that were refurbished, replaced, or not treated. Materials and methods: Twenty-three patients were included, ages 18-80 ...
    • Magnetic surgery: results from first prospective clinical trial in 50 patients 
      Rivas, Homero; Robles, Ignacio; Riquelme, Francisco; Vivanco, Marcelo; Jimenez, Julio; Marinkovic Gómez, Boris; Uribe Maturana, Mario (Lippincott Williams & Wilkins, 2018)
      Objective:To evaluate a new magnetic surgical system during reduced-port laparoscopic cholecystectomy in a prospective, multicenter clinical trial.Background:Laparoscopic instrumentation coupled by magnetic fields may ...
    • Mannitol and Outcome in Intracerebral Hemorrhage Propensity Score and Multivariable Intensive Blood Pressure ... 
      Wang, Xia; Arima, Hisatomi; Yang, Jie; Zhang, Shihong; Wu, Guojun; Woodward, Mark; Muñoz Venturelli, Paula; Lavados Germain, Pablo Manuel; Stapf, Christian; Robinson, Thompson; Heeley, Emma; Delcourt, Candice; Lindley, Richard I.; Parsons, Mark; Chalmers, John; Anderson, Craig S. (Lippincott Williams & Wilkins, 2015)
      Background and Purpose Mannitol is often used to reduce cerebral edema in acute intracerebral hemorrhage but without strong supporting evidence of benefit. We aimed to determine the impact of mannitol on outcome among ...
    • Mannitol and outcome in intracerebral hemorrhage: Propensity score and multivariable intensive blood pressure ... 
      Wang, Xia; Arima, Hisatomi; Yang, Jie; Zhang, Shihong; Wu, Guojun; Woodward, Mark; Muñoz Venturelli, Paula; Lavados Germain, Pablo Manuel; Stapf, Christian; Robinson, Thompson; Heeley, Emma; Delcourt, Candice; Lindley, Richard I.; Parsons, Mark; Chalmers, John; Anderson, Craig S. (Lippincott Williams and Wilkins, 2015)
      © 2015 American Heart Association, Inc. Background and Purpose.Mannitol is often used to reduce cerebral edema in acute intracerebral hemorrhage but without strong supporting evidence of benefit. We aimed to determine the ...