Browsing by Subject "Cyclin-dependent kinase 5"

Now showing items 1-3 of 3

    • Bioinformatic survey for new physiological substrates of Cyclin-dependent kinase 5 
      Bórquez Muñoz, Daniel; Olmos, Cristina; Álvarez, Sebastián; Genova, Alex Di; Maass Sepúlveda, Alejandro; González Billault, Christian (Elsevier, 2013)
      Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase predominantly active in the nervous system where it regulates several processes such as neuronal migration, cytoskeletal dynamics, axonal ...
    • Cdk5 regulates Rap1 activity 
      Utreras Puratich, Elías; Henríquez, Daniel R.; Contreras Vallejos, Erick; Olmos, Cristina; Di Genova, Alex; Maass Sepúlveda, Alejandro; Kulkarni, Ashok B.; González Billault, Christian (2013)
      Rap1 signaling is important for migration, differentiation, axonal growth, and during neuronal polarity. Rap1 can be activated by external stimuli, which in turn regulates specific guanine nucleotide exchange factors such ...
    • Oxidative stress promotes τ dephosphorylation in neuronal cells: The roles of cdk5 and PP1 
      Zambrano, Cristian A.; Egaña, José T.; Núñez González, Marco; Maccioni Baraona, Ricardo; González Billault, Christian (2004)
      Oxidative stress has been demonstrated to produce modifications in several intracellular proteins that lead to alterations in their activities. Alzheimer's disease is related to an increase of oxidative stress markers, ...