Browsing by Subject "Gastric cancer"

Now showing items 1-20 of 23

    • A Molecular stratification of chilean gastric cancer patients with potential clinical applicability 
      Pinto, Mauricio; Córdova Delgado, Miguel; Martínez Retamal, Ignacio; Muñoz Medel, Matías; Bravo, M. Loreto; Duran, Doris; Toledo Villanueva, Francisco Javier; Sánchez, César; Acevedo, Francisco; Mondaca, Sebastián; Koch, Erica; Ibáñez, Carolina; Galindo, Héctor; Madrid, Jorge; Nervi, Bruno; Peña, José; Torres, Javiera; Owen, Gareth I.; Corvalán, Alejandro H.; Armisén, Ricardo; Garrido, Marcelo (MDPI, 2020)
      Gastric cancer (GC) is a complex and heterogeneous disease. In recent decades, The Cancer Genome Atlas (TCGA) and the Asian Cancer Research Group (ACRG) defined GC molecular subtypes. Unfortunately, these systems require ...
    • Clinical significance of tumor expression of major histocompatibility complex class I-related chains A and ... 
      Hager Ribeiro, Carolina; Kramm, Karina; Gálvez Jirón, Felipe; Pola, Víctor; Bustamante Zamorano, Marco; Contreras Muñoz, Héctor; Sabag, Andrea; Garrido Tapia, Macarena; Hernández, Carolina; Zúñiga, Roberto; Collazo, Norberto; Sotelo, Pablo Hernán; Morales, Camila; Mercado, Luis; Catalán Martina, Diego; Aguillón Gutiérrez, Juan Carlos; Molina, María Carmen (Spandidos Publ. Ltd., 2016)
      Gastric cancer (GC) is the third most common cause of cancer death worldwide. Natural killer cells play an important role in the immune defense against transformed cells. They express the activating receptor NKG2D, whose ...
    • Decreased invariant natural killer T-cell-mediated antitumor immune response in patients with gastric cancer 
      Ascui, Gabriel; Gálvez Jirón, Felipe; Kramm, Karina; Schafer, Carolina; Siña, Josefina; Pola, Víctor; Cristi, Francisca; Hernández, Carolina; Garrido Tapia, Macarena; Pesce Reyes, Bárbara; Bustamante Zamorano, Marco; Fluxá Rojas, Paula; Molina Sampayo, María Carmen; Ribeiro, Carolina H. (Wiley, 2020)
      Gastric cancer (GC) is the third most common cause of cancer-related death worldwide. Invariant natural killer T (iNKT) cells are innate-like cytotoxic T lymphocytes involved in tumor immune surveillance. They can be ...
    • Effects of preparation on catalytic, magnetic and hybrid micromotors on their functional features and ... 
      Báez Cornejo, Daniela; Ramos Peroni, Gabriel; Corvalán Aguilar, Alejandro; Cordero Garayar, María Luisa; Bollo Dragnic, Soledad; Kogan Bocian, Marcelo (Elsevier, 2020)
      Artificial micromotors evolve to improve multitasking performance in different research areas, and different power sources are combined to give rise to hybrid micromotors. Such combinations can alter physical features and ...
    • Gastric cancer: Nanoparticles as tools to improve treatment efficacy 
      Guerrero, Ariel R.; Oyarzún Ampuero, Felipe; Hassan, Natalia; Corvalán, Alejandro; Quest, Andrew F. G.; Kogan Bocian, Marcelo (Bentham Science, 2016)
      In recent years, advances in nanotechnology have raised the specter of developing effective agents for the treatment of high-impact diseases, like gastric cancer, which remains one of the major causes of cancer deaths ...
    • Helicobacter pylori -induced inflammation and epigenetic changes during gastric carcinogenesis 
      Valenzuela, Manuel A.; Canales, Jimena; Corvalán, Alejandro H.; Quest, Andrew F. G. (WJG Press, 2015)
      © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. The sequence of events associated with the development of gastric cancer has been described as "the gastric precancerous cascade". ...
    • Helicobacter pylori and epigenetic mechanisms underlying gastric carcinogenesis 
      Valenzuela, Manuel A.; Canales, Jimena; Corvalán, Alejandro H.; Quest, Andrew F. G. (Baishideng Publishing Group Inc., 2015)
      The sequence of events associated with the development of gastric cancer has been described as "the gastric precancerous cascade". This cascade is a dynamic process that includes lesions, such as atrophic gastritis, ...
    • Helicobacter pylori and gastric cancer: adaptive cellular mechanisms involved in disease progression 
      Díaz, Paula; Valenzuela Valderrama, Manuel; Bravo, Jimena; Quest, Andrew F. G. (Frontiers Media SA, 2018)
      Helicobacter pylori (H. pylori) infection is the major risk factor associated with the development of gastric cancer. The transition from normal mucosa to non-atrophic gastritis, triggered primarily by H. pylori infection, ...
    • Helicobacter pylori outer membrane vesicles and extracellular vesicles from helicobacter pylori-infected ... 
      González, María Fernanda; Paredes Díaz, Paula Andrea; Sandoval Bórquez, Alejandra; Herrera, Daniela; Geoffery Quest, Andrew (MDPI, 2021)
      Extracellular vesicles (EVs) are cell-derived vesicles important in intercellular communication that play an essential role in host-pathogen interactions, spreading pathogen-derived as well as host-derived molecules during ...
    • IL-8-251T>A (rs4073) polymorphism is associated with prognosis in gastric cancer patients 
      González Hormazábal, Patricio; Romero, Sandra; Musleh, Maher; Bustamante, Marco; Stambuk, Juan; Pisano, Raul; Lanzarini, Enrique; Chiong, Hector; Rojas, Jorge; Castro, Victor Gonzalo; Jara, Lilian; Berger, Zoltan (International Institute of Anticancer Research, 2018)
      © 2018 International Institute of Anticancer Research. All rights reserved. Background/Aim: Inflammation is a key process in gastric carcinogenesis. Cytokines are mediators of inflammation and are involved in metastasis ...
    • Increased expression of p2ry2, cd248 and ephb1 in gastric cancers from chilean patients 
      Aquea, Gisela; Bresky, Gustavo; Lancellotti, Domingo; Madariaga, Juan Andrés; Zaffiri, Vittorio; Urzúa Tobar, Ulises; Haberle, Sergio; Bernal, Giuliano (National Cancer Center, 2014)
      Background: Gastric cancer (GC) ranks as one of the major causes of mortality due to cancer worldwide. In Chile, it is currently the leading cause of cancer death. Identification of novel molecular markers that may help ...
    • Inverse expression of survivin and reprimo correlates with poor patient prognosis in gastric cancer 
      Cerda-Opazo, Paulina; Valenzuela Valderrama, Manuel; Wichmann, Ignacio; Rodríguez, Andrés; Contreras Reyes, Daniel Alberto; Fernández, Elmer A.; Carrasco Aviño, Gonzalo; Corvalán, Alejandro H.; Quest, Andrew F. G. (Impact Journals LLC, 2018)
      © Cerda-Opazo et al. BACKGROUND: The objective of the study was to determine the relationship between Survivin and Reprimo transcript/protein expression levels, and gastric cancer outcome. METHODS: In silico correlations ...
    • Major Histocompatibility Complex Class I-Related Chain A (MICA) allelic variants associate with susceptibility ... 
      Toledo Stuardo, Karen; Ribeiro, Carolina H.; Canals Cifuentes, María Andrea; Morales, Marcela; Gárate, Valentina; Rodríguez Siza, José; Tello, Samantha; Bustamante, Marco; Armisen, Ricardo; Matthies Eyzaguirre, Douglas Johans; Zapata Torres, Gerald Amilcar; González Hormazábal, Patricio; Molina Sampayo, María Carmen (Frontiers Media, 2021)
      Gastric cancer (GC) is the fifth most prevalent type of cancer worldwide. Gastric tumor cells express MICA protein, a ligand to NKG2D receptor that triggers natural killer (NK) cells effector functions for early tumor ...
    • MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer 
      Sandoval Borquez, Alejandra; Polakovicova, Iva; Carrasco Véliz, Nicolás; Lobos González, Lorena; Riquelme, Ismael; Carrasco Aviño, Gonzalo; Bizama, Carolina; Norero, Enrique; Owen, Gareth I.; Roa, Juan; Corvalán, Alejandro H. (Biomed Central Ltd., 2017)
      Background: Multiple aberrant microRNA expression has been reported in gastric cancer. Among them, microRNA-335-5p (miR-335), a microRNA regulated by DNA methylation, has been reported to possess both tumor suppressor and ...
    • NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with ... 
      González Hormazábal, Patricio; Peláez, Diana; Musleh Katan, Maher Elías; Bustamante, Marco; Stambuk Mayorga, Juan Antonio; Pisano, Raúl; Valladares Hernández, Héctor; Lanzarini Sobrevía, Enrique Giovani; Chiong, Héctor; Suazo Sanhueza, José Lorenzo; Quiñones Sepúlveda, Luis Abel; Varela Figueroa, Nelson Miguel Edgardo; Castro, Gonzalo; Jara Sosa, Lilian Elena; Berger, Zoltan (Sociedad de Biología de Chile, 2021)
      BackgroundHelicobacter pylori is detected by pathogen recognition receptors including toll-like receptors (TLR) and nucleotide-binding oligomerization domain (NOD)-like receptors, eliciting an innate immune response against ...
    • Okadaic acid toxin at sublethal dose produced cell proliferation in gastric and colon epithelial cell lines 
      Del Campo, Miguel; Toledo, Héctor; Lagos, Néstor (2013)
      The aim of this study was to analyze the effect of Okadaic Acid (OA) on the proliferation of gastric and colon epithelial cells, the main target tissues of the toxin. We hypothesized that OA, at sublethal doses, activates ...
    • Organic and Inorganic Nanoparticles for Prevention and Diagnosis of Gastric Cancer 
      Oyarzún Ampuero, Felipe; Guerrero Hernández, Ariel; Hassan López, Natalia; Morales Valenzuela, Javier; Bollo Dragnic, Soledad; Corvalán Rodríguez, Alejandro; Quest, Andrew F. G.; Kogan Bocian, Marcelo (Bentham, 2015)
      Organic and inorganic nanoparticles show great potential for cancer diagnosis and treatment. Because gastric cancer (GC) represents the second most deadly type of neoplasia worldwide, continued research efforts by scientists ...
    • Polymorphisms in RAS/RAF/MEK/ERK pathway are associated with gastric cancer 
      González Hormazábal, Patricio; Musleh, Maher; Bustamante, Marco; Stambuk, Juan; Pisano, Raul; Valladares, Hector; Lanzarini, Enrique; Chiong, Hector; Rojas, Jorge; Suazo, Jose; Gonzalo Castro, V.; Jara, Lilian; Berger, Zoltan (MDPI AG, 2019)
      The RAS/RAF/MEK/ERK pathway regulates certain cellular functions, including cell proliferation, differentiation, survival, and apoptosis. Dysregulation of this pathway leads to the occurrence and progression of cancers ...
    • Role of cytokine gene polymorphisms in gastric cancer risk in Chile 
      González Hormazábal, Patricio; Musleh, Maher; Bustamante, Marco; Stambuk, Juan; Escandar, Susana; Valladares, Hector; Lanzarini, Enrique; Chiong, Hector; Rojas, Jorge; Castro, V. Gonzalo; Rubio-Reyes, Cristian; Jara, Lilian; Berger, Zoltan (International Institute of Anticancer Research, 2014)
      Aim: To assess the role of pro- and anti-inflammatory polymorphisms in gastric cancer susceptibility. Patients and Methods: We genotyped 12 polymorphisms in eight cytokine genes (Interleukin-1β-IL1B-, IL8, IL17A, IL17F, ...
    • The conundrum of the Epstein Barr virus associated gastric carcinoma in the Americas 
      Carrasco Aviño, Gonzalo; Riquelme, Ismael; Padilla, Oslando; Villaseca, Miguel; Aguayo González, Francisco; Corvalan, Alejandro H. (Impact Journals, 2017)
      Epstein-Barr virus-associated gastric carcinoma shows a higher prevalence in the Americas than Asia. We summarize all studies of Epstein Barr virus-associated gastric carcinoma in the Americas, focusing on host characteristics, ...