Browsing by Subject "Hepatotoxicity"

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    • The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon ... 
      Campos, Gisela; Schmidt Heck, Wolfgang; Ghallab, Ahmed; Rochlitz, Katharina; Putter, Larissa; Medinas Bilches, Danilo; Hetz Flores, Claudio; Widera, Agata; Cadenas, Cristina; Begher-Tibbe, Brigitte; Reif, Raymond; Gunther, Georgia; Sachinidis, Agapios; Hengstler, Jan G.; Godoy, Patricio (Springer, 2014)
      Since xenobiotics enter the organism via the liver, hepatocytes must cope with numerous perturbations, including modifications of proteins leading to endoplasmic reticulum stress (ER-stress). This triggers a signaling pathway ...