Browsing by Subject "Mammalian-cells"

Now showing items 1-2 of 2

    • Interactome screening identifies the ER luminal chaperone Hsp47 as a regulator of the unfolded protein ... 
      Sepúlveda, Denisse; Rojas Rivera, Diego; Rodríguez, Diego; Kohler, Andrés; Urra, Hery; Carreras Sureda, Amado; Hazari, Younis; Sierralta, Jimena; Hetz Flores, Claudio (Cell Press, 2018)
      Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a dynamic signaling network known as the unfolded protein response (UPR). IRE1a is a major UPR transducer, determining cell fate under ER stress. We ...
    • Proteostasis control by the unfolded protein response 
      Hetz Flores, Claudio; Chevet, Eric; Oakes, Scott A. (Macmillan, 2015)
      Stress induced by accumulation of misfolded proteins in the endoplasmic reticulum is observed in many physiological and pathological conditions. To cope with endoplasmic reticulum stress, cells activate the unfolded protein ...