Browsing by Subject "Pancreatic beta-cells"

Now showing items 1-3 of 3

    • Mechanisms, regulation and functions of the unfolded protein response 
      Hetz Flores, Claudio; Zhang, Kezhong; Kaufman, Randal J. (Nature, 2020)
      The unfolded protein response (UPR) comprises a network of signalling pathways that reprogramme transcription, translation and protein modifications to relieve the load of unfolded or misfolded proteins in the endoplasmic ...
    • Proteostasis control by the unfolded protein response 
      Hetz Flores, Claudio; Chevet, Eric; Oakes, Scott A. (Macmillan, 2015)
      Stress induced by accumulation of misfolded proteins in the endoplasmic reticulum is observed in many physiological and pathological conditions. To cope with endoplasmic reticulum stress, cells activate the unfolded protein ...
    • Quercetin prevents diastolic dysfunction induced by a high-cholesterol diet: role of oxidative stress and ... 
      Castillo, Rodrigo L.; Herrera Videla, Emilio; González Candia, Alejandro; Reyes Farías, Marjorie; Jara, Nicole de la; Peña, Juan Pedro; Carrasco Pozo, Catalina (Hindawi Ltd, 2018)
      Alterations in cardiac energy metabolism play a key role in the pathogenesis of diabetic cardiomyopathy. Hypercholesterolemia associated with bioenergetic impairment and oxidative stress has not been well characterized in ...