Browsing by Author "Alzate Morales, Jans"

Now showing items 1-3 of 3

    • Neonicotinic analogues: Selective antagonists for a4b2 nicotinic acetylcholine receptors 
      Faundez Parraguez, Manuel; Farias Rabelo, Nicolas; Gonzalez Gutierrez, Juan Pablo; Etcheverry Berrios, Alvaro; Alzate Morales, Jans; Adasme-Carreño, Francisco; Varas, Rodrigo; Bermúdez, Isabel; Iturriaga-Vásquez, Patricio (Elsevier, 2013)
      Nicotine is an agonist of nicotinic acetylcholine receptors (nAChRs)that has been extensively used as a template for the synthesis of a4b2-prefer ring nAChRs.Here,we used the N-methyl-pyrrolidine moiety of nicotine to ...
    • Studying the phosphoryl transfer mechanism of the: E. coli phosphofructokinase-2: From X-ray structure to ... 
      Murillo López, Juliana; Zinovjev, Kirill; Pereira, Humberto; Caniuguir, Andrés; Garratt, Richard; Babul, Jorge; Recabarren, Rodrigo; Alzate Morales, Jans; Caballero, Julio; Tuñón, Iñaki; Cabrera, Ricardo (Royal Society of Chemistry, 2019)
      Phosphofructokinases (Pfks) catalyze the ATP-dependent phosphorylation of fructose-6-phosphate (F6P) and they are regulated in a wide variety of organisms. Although numerous aspects of the kinetics and regulation have been ...
    • Theoretical study on CDK2 inhibitors using a global softness obtained from the density of states 
      Alzate Morales, Jans; Tiznado Vásquez, William; Santos Vargas, Juan; Cárdenas Valencia, Carlos; Contreras Ramos, Renato (2007)
      We report a theoretical study on a series of CDK2 inhibitors using a set of global reactivity indices defined in terms of the density of states. The statistical analysis was performed on the basis of two groups of 11 and ...