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    • Reconstructed ancestral enzymes reveal that negative selection drove the evolution of substrate specificity in ADP-dependent kinases 

      Castro Fernández, Víctor; Herrera Morande, Alejandra; Zamorano Sarria, Ricardo; Merino, Felipe; González Órdenes, Felipe; Padilla Salinas, Felipe; Pereira, Humberto M.; Brandao Neto, José; Garratt, Richard C.; Guixé Leguía, Victoria Cristina (American Society for Biochemistry and Molecular Biology, 2017)
      One central goal in molecular evolution is to pinpoint the mechanisms and evolutionary forces that cause an enzyme to change its substrate specificity; however, these processes remain largely unexplored. Using the glycolytic ...