Now showing items 1-6 of 6

    • Cognitive impairment and Alzheimer's disease: Links with oxidative stress and cholesterol metabolism 

      Sekler, Alejandra; Jiménez, José M.; Rojo, Leonel; Pastene, Edgard; Fuentes, Patricio; Slachevsky Chonchol, Andrea; Maccioni Baraona, Ricardo (BioMed Central, 2008)
      Oxidative stress has be en implicated in the progression of a number of neurodegenerative diseases, inc1uding Alzheimer's disease (AD), Parkinson's disease and amyotrophic lateral sclerosis. We carried out a~ in-depth ...
    • Dead tumor cells expressing infectious salmon anemia virus fusogenic protein favor antigen cross-priming in vitro 

      Morales, Jonathan; Barrera Avalos, Carlos; Castro, Carlos; Castillo, Stephanie; Barrientos, Claudio; Robles Planells, Claudia; López, Ximena; Torres, Ernesto; Montoya, Margarita; Cortez San Martin, Marcelo; Riquelme, Denise; Escobar Álvarez, Alejandro; Fernández, Ricardo; Imarai, Mónica; Sauma Mahaluf, Daniela; Rojo, Leonel E.; Leiva Salcedo, Elias; Acuña Castillo, Claudio (Frontiers media SA, 2017)
      Antigen cross-presentation is a crucial step in the assembly of an antitumor immune response leading to activation of naive CD8 T cells. This process has been extensively used in clinical trials, in which dendritic cells ...
    • Insulin Resistance and Alzheimer's Disease: Molecular Links & Clinical Implications 

      Neumann, Karen F.; Rojo, Leonel; Navarrete, Leonardo P.; Farías, Gonzalo; Reyes, Paula; Maccioni Baraona, Ricardo (BENTHAM SCIENCE PUBL LTD, 2008-10)
      Hyperinsulinemia as well as type II diabetes mellitus are among the risk factors for Alzheimer´s disease (AD). However, the molecular and cellular basis that link insulin resistance disorders and diabetes with AD are far ...
    • Mild cognitive impairment and Alzheimer patients display different levels of redox-active CSF iron 

      Lavados Montes, Manuel; Guillón Moretti, Marta; Mujica, María Cristina; Rojo, Leonel; Fuentes, Patricio; Maccioni Baraona, Ricardo (IOS PRESS, 2008)
      Oxidative stress constitutes a hallmark of Alzheimer’s disease (AD). Recent studies also point to redox active metals such as iron, copper and zinc in mediating oxidative stress in AD pathogenesis. However, the reactivity ...
    • Neuroinflammation: Implications for the pathogenesis and molecular diagnosis of Alzheimer's disease 

      Rojo, Leonel; Fernández Darraz, Jorge; Maccioni, Andrea A.; González Jiménez, José; Maccioni Baraona, Ricardo (ELSEVIER SCIENCE INC, 2007-05-31)
      During the past few years, an increasing set of evidence has supported the major role of deregulation of the interaction patterns between glial cells and neurons in the pathway toward neuronal degeneration. Neurons and ...
    • The Role of Neuroimmunomodulation in Alzheimer's Disease 

      Maccioni Baraona, Ricardo; Rojo, Leonel; Fernández, Jorge A.; Kuljis, Rodrigo O. (BLACKWELL, 2009)
      The idea that alterations in the brain immunomodulation are critical for Alzheimer’s disease (AD) pathogenesis provides the most integrative view on this cognitive disorder, considering that converging research lines ...