Browsing by Author "b3ecc49b-9aea-4927-9954-2dedb32617fc"
Now showing items 1-20 of 21
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Bono Merino, María Rosa; Reyes, Lilian I.; Rosemblatt Silber, Mario César (1999)We present a simple non-radioactive cytometry-based assay that permits the simultaneous quantitation of cell adhesion of distinct subsets of cells contained in a mixture without any previous fractionation. The procedure ...
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Sauma Mahaluf, Daniela; Crisóstomo, Natalia; Fuentes, Camila; Gleisner, María Alejandra; Hidalgo, Yessia; Fuenzalida, María José; Rosemblatt Silber, Mario César; Bono Merino, María Rosa (Springer, 2017)Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by increased autoantibody production that leads to multiple tissue injuries. Dendritic cells (DCs) are important orchestrators of immune responses ...
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Rosemblatt Silber, Mario César; Fellous, A.; Mazie, J. C.; Delacourte, A.; Defossez, A. (1989)In Alzheimer's disease, the most characteristic neuropathological changes are the formation of neurofibrillary tangles (NFT) and neuritic plaques (NP) characterized by the presence of bundles of paired helical filaments ...
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Lennon Duménil, Ana María; Ottone, Catherine; Rosemblatt Silber, Mario César; Fellous, Marc; Bono Merino, María Rosa; Alcaïde-Loridan, Catherine (Springer-Verlag, 1998)In this study, various sets of somatic cell hybrids, generated by the fusion of epithelial cell lines with B-lymphoblastoid cell lines, were analyzed for the expression of major histocompatibility complex (MHC) class ...
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Pino Lagos, Karina; Michea, Paula; Sauma Mahaluf, Daniela; Alba, Andrea; Morales, Jorge; Bono Merino, María Rosa; Fierro, Alberto; Rosemblatt Silber, Mario César (Society of Biology of Chile, 2010)One of the mechanisms for generation of tolerance involves immature dendritic cells (DCs) and a subpopulation of regulatory CD4+ CD25+ T lymphocytes (TREG). The purpose of this work was to analyze how Cyclosporine A (CsA), ...
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Gleisner, M. A.; Rosemblatt Silber, Mario César; Fierro, J. A.; Bono Merino, María Rosa (2011)Background: Dendritic cells (DCs) are professional antigen-presenting cells able to induce immunity or tolerance. The interactions of immature DCs with naive T lymphocytes induce peripheral tolerance through mechanisms ...
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Moore, C.; Sauma Mahaluf, Daniela; Reyes Pérez, P. A.; Morales Peña, José; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Fierro, J. A. (ELSEVIER, 2010)Background. CD4 CD25 Foxp3 regulatory T cells (Treg) play an essential role in immune tolerance, suppressing responses against self-antigens. Additionally, Treg play an important role in maintaining immunosuppression ...
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Fierro, Alberto; Mora, J. Rodrigo; Bono Merino, María Rosa; Morales, Jorge; Buckel, Erwin; Sauma Mahaluf, Daniela; Rosemblatt Silber, Mario César (2003)
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Jørgensen, Trine N.; Alfaro, Jennifer; Enriquez, Hilda L.; Jiang, Chao; Loo, William M.; Atencio, Stephanie; Gubbels Bupp, Melanie R.; Mailloux, Christina M.; Metzger, Troy; Flannery, Shannon; Rozzo, Stephen J.; Kotzin, Brian L.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; (2010)Autoantibodies are of central importance in the pathogenesis of Ab-mediated autoimmune disorders. The murine lupus susceptibility locus Nba2 on chromosome 1 and the syntenic human locus are associated with a loss of immune ...
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Sauma Mahaluf, Daniela; Espejo, P.; Ramirez, A.; Fierro, A.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa (2011)The Notch signalling pathway has recently been linked to T helper 1 (Th1)/T helper 2 (Th2) cell polarization via a mechanism involving differential expression of Notch ligands, Delta-like and Jagged, in antigen-presenting ...
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Salas Cortés, Laura; Jaubert, Francis; Bono Merino, María Rosa; Fellous, Marc; Rosemblatt Silber, Mario César (2001)Sex determination in mammals is controlled by the SRY gene located on the Y chromosome. It encodes a protein containing a DNA-binding and DNA-bending domain. In spite of recent advances in the identification of the mechanisms ...
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Donas, C.; Carrasco, M.; Fritz, M.; Prado, C.; Tejon, G.; Osorio Barrios, F.; Manríquez, V.; Bono Merino, María Rosa; Pacheco, R.; Loyola, A.; Rosemblatt Silber, Mario César (2016)
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Flores Santibañez, Felipe; Cuadra, Barbara; Fernández, Dominique; Rosemblatt, María V.; Nunez, Sarah; Cruz, Pablo; Gálvez Cancino, Felipe Ignacio; Cárdenas, J.C.; Lladser, Álvaro; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Sauma Mahaluf, Daniela (Frontiers Media SA, 2018)Memory CD8(+) T cells are ideal candidates for cancer immunotherapy because they can mediate long-term protection against tumors. However, the therapeutic potential of different in vitro-generated CD8(+) T cell effector ...
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Sauma Mahaluf, Daniela; Mora, J. R.; Fierro, Alberto; Morales, J.; Herzog, C.; Buckel, E.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa (2002)
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Villablanca, Eduardo J.; Wang, Sen; De Calisto, Jaime; Gomes, Daniel C.O.; Kane, Maureen A.; Napoli, Joseph L.; Blaner, William S.; Kagechika, Hiroyuki; Blomhoff, Rune; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Von Andrian, Ulrich H.; Mora, J. Rodrigo (W.B. Saunders, 2011)Background & Aims: Gut-associated dendritic cells (DC) metabolize vitamin A into all-trans retinoic acid (RA), which is required to induce lymphocytes to localize to the gastrointestinal tract and promotes the differentiation ...
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Sauma Mahaluf, Daniela; Ramirez, A.; Alvarez, K.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa (2012)The Notch signalling pathway regulates several aspects of cellular differentiation such as T lineage commitment and effector functions on peripheral T cells; however, there is limited information regarding Notch receptor ...
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Rivas Yáñez, Elizabeth; Barrera Ávalos, Carlos; Parra Tello, Brian; Briceño, Pedro F.; Rosemblatt, Mariana V.; Saavedra Almarza, Juan Pablo; Rosemblatt Silber, Mario; Acuña Castillo, Claudio; Bono Merino, María Rosa; Sauma Mahaluf, Daniela (MDPI, 2020)The P2X7 receptor is a ligand-gated, cation-selective channel whose main physiological ligand is ATP. P2X7 receptor activation may also be triggered by ARTC2.2-dependent ADP ribosylation in the presence of extracellular ...
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Bono Merino, María Rosa; Tejón, Gabriela; Flores Santibáñez, Felipe; Fernández, Dominique; Rosemblatt Silber, Mario César; Sauma Mahaluf, Daniela (MDPI, 2016)Vitamin A, a generic designation for an array of organic molecules that includes retinal, retinol and retinoic acid, is an essential nutrient needed in a wide array of aspects including the proper functioning of the visual ...
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Hidalgo, Y.; Fuenzalida, M. J.; Rosemblatt Silber, Mario César; Sauma Mahaluf, Daniela; Bono Merino, María Rosa (2016)
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Candia, Enzo; Reyes, Paz; Covian, Camila; Rodríguez, Francisco; Wainstein, Nicolás; Morales, Jorge; Mosso, Claudio; Rosemblatt Silber, Mario César; Fierro, Juan Alberto (Public Library Science, 2017)Adoptive transfer of CD4+CD25+FOXP3+ regulatory T cells (Treg cells) has been successfully utilized to treat graft versus host disease and represents a promising strategy for the treatment of autoimmune diseases and ...