Browsing by Author "Abin Carriquiry, Juan Andrés"

Now showing items 1-4 of 4

    • C3-halogenation of cytisine generates potent and efficacious nicotinic receptor agonists 
      Abin Carriquiry, Juan Andrés; Voutilainen, Merja H.; Barik, Jacques; Cassels Niven, Bruce; Iturriaga-Vásquez, Patricio; Bermúdez, Isabel; Durand, Claudia; Dajas, Federico; Wonnacott, Susan (ELSEVIER, 2006)
      Neuronal nicotinic acetylcholine receptors subserve predominantly modulatory roles in the brain, making them attractive therapeutic targets. Natural products provide key leads in the quest for nicotinic receptor subtype-selective ...
    • In silico characterization of cytisinoids docked into an acetylcholine binding protein 
      Abin Carriquiry, Juan Andrés; Paulino Zunini, Margot; Cassels Niven, Bruce; Wonnacott, Susan; Dajas, Federico (PERGAMON-ELSEVIER SCIENCE LTD, 2010-05-06)
      Homology models of nicotinic acetylcholine receptors (nAChRs) suggest that subtype specificity is due to non-conserved residues in the complementary subunit of the ligand-binding pocket. Cytisine and its derivatives ...
    • Increase in locomotor activity after acute administration of the nicotinic receptor agonist 3-bromocytisine in rats 
      Abin Carriquiry, Juan Andrés; Urbanavicius, Jessika; Scorza, Cecilia; Rebolledo Fuentes, Marco; Wonnacott, Susan; Cassels Niven, Bruce; Dajas, Federico (ELSEVIER, 2010)
      Nicotinic acetylcholine receptors influence striatal dopaminergic activity and its outcome on motor behavior. For these reasons, nicotinic receptors have been considered as therapeutically relevant targets for Parkinson's ...
    • Increase in locomotor activity after acute administration of the nicotinic receptor agonist 3-bromocytisine in rats 
      Abin Carriquiry, Juan Andrés; Urbanavicius, Jessika; Scorza, Cecilia; Rebolledo Fuentes, Marco; Wonnacott, Susan; Cassels Niven, Bruce; Dajas, Federico (Elsevier B.V., 2010-02-23)
      Nicotinic acetylcholine receptors influence striatal dopaminergic activity and its outcome on motor behavior. For these reasons, nicotinic receptors have been considered as therapeutically relevant targets for Parkinson's ...