Browsing by Author "Caniuguir, Andrés"
Now showing items 1-7 of 7
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Currie, Mark A.; Merino, Felipe; Skarina, Tatiana; Wong, Andrew H. Y.; Singer, Alexander; Brown, Greg; Savchenko, Alexei; Caniuguir, Andrés; Guixé Leguía, Victoria Cristina; Yakunin, Alexander F.; Jia, Zongchao (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2009-06-24)Some hyperthermophilic archaea use a modified glycolytic pathway that employs an ADP-dependent glucokinase (ADPGK) and an ADP-dependent phosphofructokinase (ADP-PFK) or, in the case of Methanococcus jannaschii, a ...
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Merino, Felipe; Rivas Pardo, Jaime Andrés; Caniuguir, Andrés; García, Ivonne; Guixé Leguía, Victoria Cristina (Elsevier, 2012)In some archaea, glucose degradation proceeds through a modified version of the Embden-Meyerhof pathway where glucose and fructose-6-P phosphorylation is carried out by kinases that use ADP as the phosphoryl donor. Unlike ...
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Cabrera Paucar, Ricardo; Caniuguir, Andrés; Ambrosio, Andre L. B.; Guixé Leguía, Victoria Cristina; Garratt, Richard C.; Babul Cattán, Jorge (BLACKWELL, 2006-09)Escherichia coli contains two phosphofructokinases, Pfk-1 and Pfk-2, which belong to unrelated protein families. In addition to catalytic function, the enzymes have converged in showing substrate inhibition by the nucleotide ...
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Rivas Pardo, Jaime Andrés; Caniuguir, Andrés; Wilson, Christian A.M.; Babul Cattán, Jorge; Guixé Leguía, Victoria Cristina (Elsevier, 2011)The reaction catalyzed by E. coli Pfk-2 presents a dual-cation requirement. In addition to that chelated by the nucleotide substrate, an activating cation is required to obtain full activity of the enzyme. Only Mn2+ and ...
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Caniuguir, Andrés; Cabrera Paucar, Ricardo; Báez, Mauricio; Vásquez, Claudio; Babul Cattán, Jorge; Guixé Leguía, Victoria Cristina (ELSEVIER SCIENCE BV, 2005-04-25)In a previous work, chemical modification of Cys-238 of Escherichia coli Pfk-2 raised concerns on the importance of the dimeric state of Pfk-2 for enzyme activity, whereas modification of Cys-295 impaired the enzymatic ...
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Murillo López, Juliana; Zinovjev, Kirill; Pereira, Humberto; Caniuguir, Andrés; Garratt, Richard; Babul, Jorge; Recabarren, Rodrigo; Alzate Morales, Jans; Caballero, Julio; Tuñón, Iñaki; Cabrera, Ricardo (Royal Society of Chemistry, 2019)Phosphofructokinases (Pfks) catalyze the ATP-dependent phosphorylation of fructose-6-phosphate (F6P) and they are regulated in a wide variety of organisms. Although numerous aspects of the kinetics and regulation have been ...
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Cabrera Paucar, Ricardo; Báez, Mauricio; Pereira, Humberto M.; Caniuguir, Andrés; Garratt, Richard C.; Babul Cattán, Jorge (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2011-02-18)Substrate inhibition by ATP is a regulatory feature of the phosphofructokinases isoenzymes from Escherichia coli (Pfk-1 and Pfk-2). Under gluconeogenic conditions, the loss of this regulation in Pfk-2 causes substrate ...