Browsing by Author "Fierro, Angélica"

Now showing items 1-6 of 6

    • 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase 
      Lühr-Sierra, Susan; Vilches-Herrera, Marcelo; Fierro, Angélica; Ramsay, Rona; Edmondson, Dale E.; Reyes Parada, Miguel; Cassels Niven, Bruce; Iturriaga-Vásquez, Patricio (ELSEVIER, 2010)
      2-Arylthiomorpholine and 2-arylthiomorpholin-5-one derivatives, designed as rigid and/or non-basic phenylethylamine analogues, were evaluated as rat and human monoamine oxidase inhibitors. Molecular docking provided ...
    • Coumarin-chalcone hybrids as inhibitors of MAO-B: Biological activity and in silico studies 
      Moya Alvarado, Guillermo Adrian; Yáñez, Osvaldo; Morales, Nicole; González González, Angélica; Areche Medina, Carlos Alberto; Núñez González, Marco Tulio; Fierro, Angélica; García Beltrán, Olimpo José (MDPI, 2021)
      Fourteen coumarin-derived compounds modified at the C3 carbon of coumarin with an alpha,beta-unsaturated ketone were synthesized. These compounds may be designated as chalcocoumarins (3-cinnamoyl-2H-chromen-2-ones). Both ...
    • Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives: ... 
      Fierro, Angélica; Osorio Olivares, Mauricio; Cassels Niven, Bruce; Edmondson, Dale E.; Sepúlveda Boza, Silvia; Reyes Parada, Miguel (Elsevier Ltd., 2007-05-22)
      Abstract—Four enantiomerically pure (S)-4-alkylthioamphetamine derivatives were evaluated as monoamine oxidase (MAO) inhibitors using the human and rat isoforms of the enzyme. Molecular dockings were performed in order ...
    • MAO inhibition by arylisopropylamines: the effect of oxygen substituents at the b-position 
      Osorio Olivares, Mauricio; Caroli Rezende, Marcos; Sepúlveda Boza, Silvia; Cassels Niven, Bruce; Fierro, Angélica (Elsevier Ltd., 2004-05-26)
      Abstract—Twenty-nine arylisopropylamines, substituted at the b-position of their side chain by an oxo, hydroxy, or methoxy group, were evaluated in vitro as MAO-A and MAO-B inhibitors. The oxo derivatives (‘cathinones’) ...
    • Monoamine Oxidase Inhibitory Properties of Optical Isomers and N-substituted Derivatives of 4-methylthioamphetamine 
      Hurtado Guzmán, Claudio; Fierro, Angélica; Iturriaga-Vásquez, Patricio; Sepúlveda Boza, Silvia; Cassels Niven, Bruce; Reyes Parada, Miguel (Taylor & Francis Ltd, 2003-03-10)
      (6)-4-Methylthioamphetamine (MTA) was resolved into its enantiomers, and a series of N-alkyl derivatives of the parent compound, as well as its a-ethyl analogue, were prepared. The monoamine oxidase (MAO) inhibitory properties ...
    • Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors 
      Vilches-Herrera, Marcelo; Miranda-Sepúlveda, Juan; Rebolledo-Fuentes, Marco; Fierro, Angélica; Lühr, Susan; Iturriaga-Vásquez, Patricio; Cassels Niven, Bruce; Reyes Parada, Miguel (Elsevier Ltd., 2009-02-08)
      A series of naphthylisopropylamine and N-benzyl-4-methylthioamphetamine derivatives were evaluated as monoamine oxidase inhibitors. Their potencies were compared with those of a series of amphetamine derivatives, to test ...