Browsing by Author "Iturriaga-Vásquez, Patricio"
Now showing items 1-20 of 22
-
(SOCIEDAD CHILENA DE QUIMICA, 2004-03)The conformational preferences of a series of 1-benzyl-1,2,3,4-tetrahydroisoquinolines (norlaudanosine and coclaurine analogues) were investigated with the aid of their H-1 NMR spectra and NOESY experiments, coupled with ...
-
(ELSEVIER, 2010)2-Arylthiomorpholine and 2-arylthiomorpholin-5-one derivatives, designed as rigid and/or non-basic phenylethylamine analogues, were evaluated as rat and human monoamine oxidase inhibitors. Molecular docking provided ...
-
(2007)(S)-Aporphine metho salts with the 1,2,9, 10 oxygenation pattern displaced radioligands from recombinant human 0 and alpha 4 beta 2 neuronal nicotinic acetylcholine receptors (nAChR) at low micromolar concentrations. The ...
-
(ELSEVIER, 2006)Neuronal nicotinic acetylcholine receptors subserve predominantly modulatory roles in the brain, making them attractive therapeutic targets. Natural products provide key leads in the quest for nicotinic receptor subtype-selective ...
-
(2009)C18H21NO3, monoclinic, .P1211 (no. 4), a = 14.169(7) Å, b=8.533(4)Å,c=19.86(1)Å,β=104. 79(2)°, V= 2322.0 Å3,Z= 6, Rgt(F) = 0.045, wRref(F2) = 0.164, T= 100 K. © by Oldenbourg Wissenschaftsverlag.
-
(2009)C18H21NO3, monoclinic, P121l (no. 4), a = 14.169(7) Å, b = 8.533(4) Å, c = 19.86(1) Å, β= 104.79(2)°, V = 2322.0 Å3, Z = 6, Rgt(F) = 0.045, wRref(F2) = 0.164, T = 100 K. © 2014 Oldenbourg Wissenschaftsverlag GmbH, Rosenheimer ...
-
(2005)C38H42N2O6, orthorhombic, P212121 (no. 19), α = 12.024(2) Å, b = 15.637(2) Å, c = 17.553(3) Å, V= 3300.2 Å3, Z = 4, Rgt(F) = 0.041, wRref(F2) = 0.109, T= 293 K. © 2014, Oldenbourg Wissenschaftsverlag München. All rights reserved.
-
(ELSEVIER SCIENCE, 2010-08-13)This work describes the preparation of a new tetraruthenated porphyrin and the corresponding polymeric film. This macromolecule consists of a Ni(II) tetrapyridylporphyrin coordinated to four [Ru(5- NO2-phen)2Cl]+ moieties. ...
-
(ELSEVIER, 2006-02-09)Petrosal ganglion neurons are depolarized and fire action potentials in response to acetylcholine and nicotine. However, little is known about the subtype(s) of nicotinic acetylcholine receptors involved, although alpha 4 ...
-
(Nature Publishing Group, 2005-06-27)1 Effects of derivatives of coclaurine (C), which mimic the ‘eastern’ or the nonquaternary halves of the alkaloids tetrandrine or d-tubocurarine, respectively, both of which are inhibitors of nicotinic acetylcholine ...
-
(SOCIEDAD CHILENA DE QUIMICA, 2004-09)Condensation of 4-methylthiobenzaldehyde with 1-nitropropane unexpectedly afforded separable amounts of both (E)- and (Z)-1-(4-methylthiophenyl)-2-nitrobutene. The H-1 and C-13 NMR spectra allowed the unequivocal assignment ...
-
(Nordic Pharmacological Society), 2014)Abstract: Amphetamine derivatives have therapeutic potential in diseases such as attention deficit hyperactivity disorder, narcolepsy and obesity. However, their prolonged use has been associated with cardiovascular ...
-
(The American Society for Pharmacology and Experimental Therapeutics, 2010-06-14)The Erythrina alkaloids erysodine and dihydro- -erythroidine (DH E) are potent and selective competitive inhibitors of 4 2 nicotinic acetylcholine receptors (nAChRs), but little is known about the molecular determinants ...
-
(AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS, 2010-06-14)(DH E) are potent and selective competitive inhibitors of 4 2 nicotinic acetylcholine receptors (nAChRs), but little is known about the molecular determinants of the sensitivity of this receptor subtype to inhibition ...
-
(SOCIEDAD CHILENA DE QUIMICA, 2006-09)Benzyltetrahydroisoquinoline (BTHIQ) molecules are able to adopt widely differing conformations that depend on the presence or absence of N-substituents. To assess the possible role of BTHIQ conformation on the affinity ...
-
(Elsevier Ltd., 2009-02-08)A series of naphthylisopropylamine and N-benzyl-4-methylthioamphetamine derivatives were evaluated as monoamine oxidase inhibitors. Their potencies were compared with those of a series of amphetamine derivatives, to test ...
-
(Elsevier, 2013)Nicotine is an agonist of nicotinic acetylcholine receptors (nAChRs)that has been extensively used as a template for the synthesis of a4b2-prefer ring nAChRs.Here,we used the N-methyl-pyrrolidine moiety of nicotine to ...
-
(2013)Nicotine is an agonist of nicotinic acetylcholine receptors (nAChRs) that has been extensively used as a template for the synthesis of α4β2-preferring nAChRs. Here, we used the N-methyl-pyrrolidine moiety of nicotine to ...
-
Simplified Tetrandrine Congeners as Possible Antihypertensive Agents with a Dual Mechanism of Action (American Chemical Society and American Society of Pharmacognosy, 2003-02-07)A series of O- and/or N-substituted derivatives of (()-coclaurine (1a) were synthesized as simplified structural mimics of the antihypertensive alkaloid tetrandrine (2) and assayed for binding to brain cortical sites ...
