Browsing by Author "Maccioni Baraona, Ricardo"

Now showing items 1-12 of 12

    • Anomalously phosphorylated tau and A beta fragments in the CSF correlates with cognitive impairment in MCI subjects 
      Maccioni Baraona, Ricardo; Lavados Montes, Manuel; Guillón Moretti, Marta; Mujica, Cristina; Bosch, Rubén; Farías, Gustavo; Fuentes, Patricio (ELSEVIER, 2006-02)
      Alzheimer's disease(AD) is a neurodegenerative disorder characterized by the presence of extracellular amyloid deposits, consisting largely of A beta peptide and the presence of intraneuronal aggregates of neurofibillary ...
    • Cognitive impairment and Alzheimer's disease: Links with oxidative stress and cholesterol metabolism 
      Sekler, Alejandra; Jiménez, José M.; Rojo, Leonel; Pastene, Edgard; Fuentes, Patricio; Slachevsky Chonchol, Andrea; Maccioni Baraona, Ricardo (BioMed Central, 2008)
      Oxidative stress has be en implicated in the progression of a number of neurodegenerative diseases, inc1uding Alzheimer's disease (AD), Parkinson's disease and amyotrophic lateral sclerosis. We carried out a~ in-depth ...
    • Effects of natural flavones and flavonols on the kinase activity of Cdk5 
      Zapata Torres, Gerald Amilcar; Opazo, Felipe; Salgado, J. Cristián; Muñoz Concha, Juan; Krautwurst, Hans; Mascayano, Carolina; Sepúlveda Boza, Silvia; Maccioni Baraona, Ricardo; Cassels Niven, Bruce (AMER CHEMICAL SOC, 2004-03)
      A number of natural and synthetic flavonoids have been assessed previously with regard to their effects on the activity of cyclin-dependent kinases (Cdk1 and -2) related to the inhibition of cell cycle progression. On the ...
    • Evidence for the participation of the neuron-specific CDK5 activator p35 during laminin-enhanced axonal growth 
      Paglini, Gabriela; Pigino, Gustavo; Kunda, Patricia; Morfini, Gerardo; Maccioni Baraona, Ricardo; Quiroga, Santiago; Ferreira, Adriana; Cáceres, Alfredo (1998)
      Cultures of cerebellar macroneurons were used to study the pattern of expression, subcellular localization, and function of the neuronal cdk5 activator p35 during laminin-enhanced axonal growth. The results obtained indicate ...
    • Insulin Resistance and Alzheimer's Disease: Molecular Links & Clinical Implications 
      Neumann, Karen F.; Rojo, Leonel; Navarrete, Leonardo P.; Farías, Gonzalo; Reyes, Paula; Maccioni Baraona, Ricardo (BENTHAM SCIENCE PUBL LTD, 2008-10)
      Hyperinsulinemia as well as type II diabetes mellitus are among the risk factors for Alzheimer´s disease (AD). However, the molecular and cellular basis that link insulin resistance disorders and diabetes with AD are far ...
    • Interleukin-3 prevents neuronal death induced by amyloid peptide 
      Zambrano, Angara; Otth, Carola; Mujica, Lorena; Concha, Ilona I.; Maccioni Baraona, Ricardo (BIOMED CENTRAL LTD, 2007-10-03)
      Background: Interleukin-3 (IL-3) is an important glycoprotein involved in regulating biological responses such as cell proliferation, survival and differentiation. Its effects are mediated via interaction with cell surface ...
    • Neuroinflammation: Implications for the pathogenesis and molecular diagnosis of Alzheimer's disease 
      Rojo, Leonel; Fernández Darraz, Jorge; Maccioni, Andrea A.; González Jiménez, José; Maccioni Baraona, Ricardo (ELSEVIER SCIENCE INC, 2007-05-31)
      During the past few years, an increasing set of evidence has supported the major role of deregulation of the interaction patterns between glial cells and neurons in the pathway toward neuronal degeneration. Neurons and ...
    • Neuroprotective effect of TNFα against the β-amyloid neurotoxicity mediated by CDK5 kinase 
      Orellana, Daniel I.; Quintanilla, Rodrigo A.; Maccioni Baraona, Ricardo (Elsevier B.V., 2006-10-21)
      The tumor necrosis factor alpha (TNFα) plays a dual role in producing either neurodegeneration or neuroprotection in the central nervous system. Despite that TNFα was initially described as a cell death inductor, ...
    • Production of nerve growth factor by beta-amyloid-stimulated astrocytes induces p75(NTR)-dependent tau ... 
      Sáez, Estefanía T.; Pehar, Mariana; Vargas, Marcelo R.; Barbeito, Luis; Maccioni Baraona, Ricardo (WILEY-LISS, 2006-10)
      Reactive astrocytes surround amyloid depositions and degenerating neurons in Alzheimer's disease (AD). It has been previously shown that P-amyloid peptide induces inflammatory-like responses in astrocytes, leading to ...
    • Regulatory roles of microtubule-associated proteins in neuronal morphogenesis. Involvement of the extracellular ... 
      Ramírez, C.; Alvarez, A.; García Abreu, J.; Gomes, F. C.A.; Moura-Neto, V.; Maccioni Baraona, Ricardo (Associacao Brasileira de Divulgacao Cientifica, 1999)
      As a result of recent investigations, the cytoskeleton can be viewed as a cytoplasmic system of interconnected filaments with three major integrative levels: self-assembling macromolecules, filamentous polymers, e.g., ...
    • The Role of Neuroimmunomodulation in Alzheimer's Disease 
      Maccioni Baraona, Ricardo; Rojo, Leonel; Fernández, Jorge A.; Kuljis, Rodrigo O. (BLACKWELL, 2009)
      The idea that alterations in the brain immunomodulation are critical for Alzheimer’s disease (AD) pathogenesis provides the most integrative view on this cognitive disorder, considering that converging research lines ...
    • The Revitalized Tau Hypothesison Alzheimer's Disease 
      Maccioni Baraona, Ricardo; Farías, Gonzalo; Morales, Inelia; Navarrete, Leonardo (Elsevier Inc., 2010-03-01)
      Many hypotheses have been raised regarding the pathophysiology of Alzheimer’s disease (AD). Because amyloid beta peptide (Ab) deposition in senile plaques appears as a late, nonspecific event, recent evidence points to tau ...