Browsing by Author "201-0535197"

Now showing items 1-14 of 14

    • alpha(2)-adrenoceptors control the release of noradrenaline but not neuropeptide Y from perivascular nerve ... 
      Donoso, M. V.; Carvajal, A.; Paredes Vargas, Alfonso; Tomic, A.; Koenig, Cecilia S.; Huidobro Toro, Juan Pablo (ELSEVIER SCIENCE INC, 2002-09)
      Neuropeptide Y (NPY) and noradrenaline (NA) are co-transmitters at many sympathetic synapses, but it is not yet clear if their release is independently regulated. To address this question, we quantified the electrically ...
    • Central ceramide signaling mediates obesity-induced precocious puberty 
      Heras, Violeta; Castellano, Juan Manuel; Fernandois, Daniela; Velasco, Inmaculada; Rodríguez Vázquez, Elvira; Roa, Juan; Vázquez, María Jesús; Ruiz Pino, Francisco; Rubio, Matías; Pineda, Rafael; Torres, Encarnación; Avendaño, María Soledad; Paredes Vargas, Alfonso; Pinilla, Leonor; Belsham, Denise; Dieguez, Carlos; Gaytan, Francisco; Casals, Nuria; López, Miguel; Tena Sempere, Manuel (Cell, 2020)
      Childhood obesity, especially in girls, is frequently bound to earlier puberty, which is linked to higher disease burden later in life. The mechanisms underlying this association remain elusive. Here we show that brain ...
    • A conditional tetracycline-regulated increase in gamma amino butyric acid production near luteinizing ... 
      Bilger, Marie; Heger, Sabine; Brann, Darrell W.; Paredes Vargas, Alfonso; Ojeda, Sergio R. (ENDOCRINE SOC, 2001-05)
      Gamma amino butyric acid (GABA) is the main inhibitory neuro-transmitter controlling LH-releasing hormone (LHRH) secretion in the mammalian hypothalamus. Whether alterations in GABA homeostasis within discrete regions of ...
    • Effects of adrenalectomy on the stress-induced changes in ovarian sympathetic tone in the rat 
      Gálvez, A.; Paredes Vargas, Alfonso; Fiedler Temer, Jenny; Venegas Santos, Mauricio; Lara Peñaloza, Hernán (HUMANA PRESS INC, 1999-04)
      A 3-wk period of stress promotes the development of ovarian cysts in rats apparently mediated by increased sympathetic nerve activity and ovarian steroid secretion. After 11 wk of stress, these parameters are indistinguishable ...
    • Effects of sympathectomy on ovarian follicular development and steroid secretion 
      Garrido Palma, Maritza; Fernandois, Daniela; Venegas Santos, Mauricio; Paredes Vargas, Alfonso (Bioscientifica Ltd., 2018)
      Recently, the influence of adrenergic activity over ovarian function, and thus fertility, has begun to gain importance. Previous studies have shown that adrenergic activity through norepinephrine (NE) participates in the ...
    • An increased intraovarian synthesis of nerve growth factor and its low affinity receptor is a principal ... 
      Lara Peñaloza, Hernán; Dissen, G. A.; Leyton Canales, Víctor; Paredes Vargas, Alfonso; Fuenzalida Cruz, Héctor; Fiedler Temer, Jenny; Ojeda, Sergio R. (ENDOCRINE SOC, 2000-03)
      A form of polycystic ovary (PCO) resembling some aspects of the human PCO syndrome can be induced in rats by a single injection of estradiol valerate (EV). An increase in sympathetic outflow to the ovary precedes, by several ...
    • Intraovarian excess of nerve growth factor increases androgen secretion and disrupts estrous cyclicity in the rat 
      Dissen, G. A.; Lara Peñaloza, Hernán; Leyton Canales, Víctor; Paredes Vargas, Alfonso; Hill, D. F.; Costa, M. E.; Martínez Serrano, A.; Ojeda, Sergio R. (ENDOCRINE SOC, 2000-03)
      A single injection of estradiol valerate induces a form of cystic ovary resembling some aspects of the human polycystic ovarian syndrome. Preceding the development of follicular cysts, there is an increase in intraovarian ...
    • Kisspeptin is involved in ovarian follicular development during aging in rats 
      Fernandois, D.; Na, E.; Cuevas, F.; Cruz, G.; Lara Peñaloza, Hernán; Paredes Vargas, Alfonso (Bioscientifica, 2016)
      We have previously reported that kisspeptin (KP) may be under the control of the sympathetic innervation of the ovary. Considering that the sympathetic activity of the ovary increases with aging, it is possible that ...
    • Maternal sympathetic stress impairs follicular development and puberty of the offspring 
      Barra, Rafael; Cruz Neculpán, Gonzalo Andrés; Mayerhofer, Artur; Paredes Vargas, Alfonso; Lara Peñaloza, Hernán (Society for Reproduction and Fertility, 2014)
      Chronic cold stress applied to adult rats activates ovarian sympathetic innervation and develops polycystic ovary (PCO) phenotype. The PCO syndrome in humans originates during early development and is expressed before or ...
    • Nerve growth factor induces the expression of functional FSH receptors in newly formed follicles of the rat ovary 
      Romero Osses, Carmen; Paredes Vargas, Alfonso; Dissen, G. A.; Ojeda, Sergio R. (ENDOCRINE SOC, 2002-04)
      The neurotrophin nerve growth factor (NGF) and its two membrane-anchored receptors are expressed in the developing ovary before the organization of the first primordial follicles. In the absence of NGF, the growth of ...
    • Ovarian localization of 11b-hydroxysteroid dehydrogenase (11bHSD): effects of ACTH stimulation and its ... 
      Amweg, A. N.; Salvetti, N. R.; Stangaferro, M. L.; Paredes Vargas, Alfonso; Lara, H. H.; Rodríguez, F. M.; Ortega, H. H. (Elsevier, 2013)
      Cystic ovarian disease (COD) is an important cause of infertility in cattle, and ACTH has been involved in regulatory mechanisms related to ovarian function associated with ovulation, steroidogenesis, and luteal function. ...
    • Peripheral and Central Mechanisms Involved in the Hormonal Control of Male and Female Reproduction 
      Rudolph, L. M.; Bentley, G.; Calandra, R.; Paredes Vargas, Alfonso; Tesone, M.; Wu, T. J.; Micevych, P. E. (Wiley, 2016)
      Reproduction involves the integration of hormonal signals acting across multiple systems to generate a synchronised physiological output. A critical component of reproduction is the luteinising hormone (LH) surge, which ...
    • Rise in endothelium-derived NO after stimulation of rat perivascular sympathetic mesenteric nerves 
      Boric, M. P.; Figueroa, X. F.; Donoso, M. V.; Paredes Vargas, Alfonso; Poblete, I.; Huidobro Toro, Juan Pablo (AMER PHYSIOLOGICAL SOC, 1999-09)
      To evaluate whether sympathetic activity induces nitric oxide (NO) production, we perfused the rat arterial mesenteric bed and measured luminally accessible norepinephrine (NE), NO, and cGMP before, during, and after ...
    • TrkB receptors are required for follicular growth and oocyte survival in the mammalian ovary 
      Romero Osses, Carmen; Dissen, G. A.; DeChiara, T. M.; Reichardt, L.; Cornea, A.; Ojeda, Sergio R.; Paredes Vargas, Alfonso; Xu, B. J. (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2004-03-15)
      Although it is well established that both follicular assembly and the initiation of follicle growth in the mammalian ovary occur independently of pituitary hormone support, the factors controlling these processes remain ...