Now showing items 1-2 of 2

    • Binding of dihydroxynaphthyl aryl ketones to tubulin colchicine site inhibits microtubule assembly 

      Gutiérrez, Eunices; Benites, Julio; Valderrama, Jaime; Buc Calderón, Pedro; Verrax, Julien; Nova Martínez, Esteban; Villanelo Lizana, Felipe; Maturana Middleton, Daniel; Escobar, Cristian; Lagos Mónaco, Rosalba; Monasterio Opazo, Octavio (Elsevier, 2015)
      Dihydroxynaphthyl aryl ketones 1e5 have been evaluated for their abilities to inhibit microtubule assembly and the binding to tubulin. Compounds 3, 4 and 5 displayed competitive inhibition against colchicine binding, and ...
    • Tubulin equilibrium unfolding followed by time-resolved fluorescence and fluorescence correlation spectroscopy 

      Sánchez, Susana A.; Brunet, Juan E.; Jameson, David M.; Lagos Mónaco, Rosalba; Monasterio Opazo, Octavio (2004)
      The pathway for the in vitro equilibrium unfolding of the tubulin heterodimer by guanidinium chloride (GdmCl) has been studied using several spectroscopic techniques, specifically circular dichroism (CD), two-photon ...