Browsing by Author "613e6be8-4531-4d6b-a293-06e4921876a2"

Now showing items 1-6 of 6

    • Antiproliferative and uncoupling effects of delocalized, lipophilic, cationic gallic acid derivatives on ... 
      Jara, José A.; Castro Castillo, Vicente; Saavedra-Olavarría, Jorge; Peredo, Liliana; Pavanni, Mario; Jaña, Fabián; Letelier, María Eugenia; Parra, Eduardo; Becker, María Inés; Morello Casté, Antonio; Kemmerling Weis, Ulrike; Maya Arango, Juan; Ferreira, Jorge (American Chemical Society, 2014)
      Tumor cells principally exhibit increased mitochondrial transmembrane potential (Δψm) and altered metabolic pathways. The therapeutic targeting and delivery of anticancer drugs to the mitochondria might improve treatment ...
    • Electrochemical, ESR and theoretical insights into the free radical generation by 1,1'-hydrocarbylenebisindazoles ... 
      Aguilera Venegas, Benjamín; Olea Azar, Claudio; Arán, Vicente J.; Maya Arango, Juan; Kemmerling Weis, Ulrike; Speisky Cosoy, Hernán; Mendizábal Emaldía, Fernando (2012)
      A comprehensive multidisciplinary study is conducted here in order to assess the electrochemical behavior of a series of 1,1'-hydrocarbylenebisindazoles derivatives and its potential use as anti-T.cruzi drugs. At first, ...
    • ESR, electrochemical, molecular modeling and biological evaluation of 4-substituted and 1,4-disubstituted ... 
      Aguilera, Benjamín; Olea Azar, Claudio; Norambuena, Ester; Arán, Vicente J.; Mendizábal Emaldía, Fernando; Lapier, Michel; Maya Arango, Juan; Kemmerling Weis, Ulrike; López Muñoz, Rodrigo (PERGAMON-ELSEVIER SCIENCE LTD, 2011-03)
      Electrochemical and ESR studies were carried out in this work with the aim of characterizing the reduction mechanisms of 4-substituted and 1,4-disubstituted 7-nitroquinoxalin-2-ones by means of cyclic voltammetry in DMSO ...
    • Multi-target heteroleptic palladium bisphosphonate complexes 
      Micaella, Cipriani; Rostan, Santiago; León, Ignacio; Li, Zhu-Hong; Gancheff, Jorge; Kemmerling Weis, Ulrike; Olea Azar, Claudio; Etcheverry, Susana; Docampo, Roberto; Gambino, Dinorah; Otero, Lucía (Springer, 2020)
      Bisphosphonates are the most commonly prescribed drugs for the treatment of osteoporosis and other bone illnesses. Some of them have also shown antiparasitic activity. In search of improving the pharmacological profile of ...
    • Platinum-based complexes of bioactive 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-Trypanosoma ... 
      Vieites, Marisol; Otero, Lucía; Santos, Diego; Olea Azar, Claudio; Norambuena, Ester; Aguirre, Gabriela; Cerecetto, Hugo; González, Mercedes; Kemmerling Weis, Ulrike; Morello Casté, Antonio; Maya Arango, Juan; Gambino, Dinorah (2009)
      Eight new platinum(II) complexes with 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-trypanosomal activity were synthesized, characterized and in vitro evaluated. Most of the complexes showed IC50 values in the ...
    • Study of 5-nitroindazoles' anti-Trypanosoma cruzi mode of action: Electrochemical behaviour and ESR ... 
      Rodríguez, Jorge; Gerpe, Alejandra; Aguirre, Gabriela; Kemmerling Weis, Ulrike; Piro, Oscar; Arán, Vicente; Maya Arango, Juan; Olea Azar, Claudio; González, Mercedes; Cerecetto, Hugo (2009)
      New indazole derivatives have been developed to know about structural requirements for adequate anti-Trypanosoma cruzi activity. In relation to position 1 of indazole ring, we have observed that a butylaminopentyl substituent ...