Browsing by Author "6d2f4e64-b3b7-47e0-b560-dbfede86c47c"

Now showing items 1-4 of 4

    • Erysodine, a competitive antagonist at neuronal nicotinic acetylcholine receptors, decreases ethanol ... 
      Quiroz, Gabriel; Guerra-Díaz, Nicolás; Iturriaga-Vásquez, Patricio; Rivera Meza, Mario; Quintanilla González, María Elena; Sotomayor Zárate, Ramón (Elsevier, 2018-09)
      Alcohol abuse is a worldwide health problem with high economic costs to health systems. Emerging evidence suggests that modulation of brain nicotinic acetylcholine receptors (nAChRs) may be a therapeutic target for alcohol ...
    • Fenofibrato -un agonista de PPARα- incrementa los niveles de la alcohol deshidrogenasa hepática: implicaciones ... 
      Muñoz, Daniel; Rivera Meza, Mario; Flores Bastías, Osvaldo; Quintanilla González, María Elena; Karahanian, Eduardo (Socidrogalcohol. Sociedad Científica Española de Estudio sobre el Alcohol, el Alcoholismo y las otras Toxocomanías, 2020)
      Tras consumir etanol, el disulfiram incrementa los niveles de acetaldehído en sangre y genera una reacción aversiva que desalienta el consumo de alcohol. Dados los importantes efectos secundarios del disulfiram, es ...
    • Hairpin Ribozyme Genes Curtail Alcohol Drinking: from Rational Design to in vivo Effects in the Rat 
      Sapag Muñoz de la Peña, Amalia; Irarrázaval Aguilera, Thergiorg; Lobos González, Lorena; Muñoz Brauning, Carlos; Quintanilla González, María Elena; Tampier de Jong, Lutske (Nature Publishing Group, 2016)
      Ribozyme genes were designed to reduce voluntary alcohol drinking in a rat model of alcohol dependence. Acetaldehyde generated from alcohol in the liver is metabolized by the mitochondrial aldehyde dehydrogenase (ALDH2) ...
    • Polymorphisms in the mitochondrial aldehyde dehydrogenase gene (Aldh2) determine peak blood acetaldehyde ... 
      Quintanilla González, María Elena; Tampier de Jong, Lutske; Sapag, Amalia; Israel Jacard, Yedy (Lippincott Williams & Wilkins, 2005)
      Dependence on alcohol, a most widely used drug, has a heritability of 50-60%. Wistar-derived rats selectively bred as low-alcohol consumers for many generations present an allele (Aldh22) of mitochondrial aldehyde ...