Browsing by Author "99a2d231-6991-42af-9e42-341fcc2c0532"
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Down syndrome and Alzheimer's disease: common molecular traits beyond the amyloid precursor protein Gómez, Wileidy; Morales, Rodrigo; Maracaja Coutinho, Vinicius; Parra Ortiz, Valentina; Nassif, Melissa (Impact Journals LLC, 2020)Alzheimer’s disease (AD) is the most prevalent type of dementia. Down syndrome (DS) is the leading genetic risk factor for Early-Onset AD, prematurely presenting the classic pathological features of the brain with AD. ...
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Nassif, Melissa; Valenzuela, Vicente; Rojas Rivera, Diego; Vidal, René; Matus, Soledad; Castillo, Karen; Fuentealba, Yerko; Kroemer, Guido; Levine, Beth; Hetz Flores, Claudio (Taylor and Francis Inc., 2014)Pharmacological activation of autophagy is becoming an attractive strategy to induce the selective degradation of aggregate-prone proteins. Recent evidence also suggests that autophagy impairment may underlie the pathogenesis ...