Browsing by Author "beadd770-5f35-4d45-b6c3-7f3cc57a240b"

Now showing items 1-13 of 13

    • An HPLC method for the determination of isoflavones and the evaluation of their antioxidant capacity in ... 
      Montero, Guillermo; Günther Sapunar, Germán; Valdés Camus, Karina; Arriagada, Francisco; Morales, Javier O. (AOAC Int, 2018)
      In this work, we developed an HPLC method to simultaneously quantify and hence evaluate the stability, distribution, and antioxidant capacity of six isoflavones: genistein, genistin, daidzein, daidzin, glycitin, and biochanin ...
    • Buccal Dosage Forms: General Considerations for Pediatric Patients 
      Montero-Padilla, Soledad; Velaga, Sitaram; Morales, Javier O. (Springer New York LLC, 2017)
      © 2016, American Association of Pharmaceutical Scientists. The development of an appropriate dosage form for pediatric patients needs to take into account several aspects, since adult drug biodistribution differs from that ...
    • Delivery of ionizable hydrophilic drugs based on pharmaceutical formulation of ion pairs and ionic liquids 
      Gamboa, Alexander; Schuessler, Nina; Soto Bustamante, Eduardo; Romero Hasler, Patricio; Meinel, Lorenz; Morales, Javier O. (Elsevier, 2020)
      New therapeutics such as antisense oligonucleotides, small interfering RNA and peptide-drug conjugates are taking great relevance in the pharmaceutical industry due to their specificity of action and their improved safety ...
    • Films loaded with insulin-coated nanoparticles (ICNP) as potential platforms for peptide buccal delivery 
      Morales, Javier O.; Huang, Siyuan; Williams, Robert O.; McConville, Jason T. (Elsevier, 2014)
      The goal of this investigation was to develop films containing insulin-coated nanoparticles and evaluate their performance in vitro as potential peptide delivery systems. To incorporate insulin into the films, a new ...
    • Formulation and delivery of macromolecules 
      Morales, Javier (Springer New York LLC, 2017)
    • Inkjet Printing of Proteins: an Experimental Approach 
      Montenegro-Nicolini, Miguel; Miranda, Víctor; Morales, Javier O. (Springer New York LLC, 2017)
      © 2016, American Association of Pharmaceutical Scientists. Peptides and proteins represent a promissory group of molecules used by the pharmaceutical industry for drug therapy with great potential for development. However, ...
    • Lipid nanoparticles for the topical delivery of retinoids and derivatives 
      Morales, Javier; Valdés, Karina; Morales, Javier; Oyarzún Ampuero, Felipe (Future Medicine Ltd., 2015)
      Retinoids are lipophilic compounds that are highly used in cosmetics/therapeutics for skin disorders. Conventional formulations are limited by poor water solubility, high chemical/photochemical instability and the irritation ...
    • Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: Evolution toward ... 
      Bejarano, Julian; Navarro Márquez, Mario F.; Morales Zavala, Francisco; Morales, Javier O.; García Carvajal, Ivonne; Araya Fuentes, Eyleen; Flores, Yvo; Verdejo, Hugo E.; Castro, Pablo F.; Lavandero González, Sergio; Kogan Bocian, Marcelo (Ivyspring International Publisher, 2018)
      © Ivyspring International Publisher. Cardiovascular diseases are the leading cause of death worldwide. Despite preventive efforts, early detection of atherosclerosis, the common pathophysiological mechanism underlying ...
    • Overview and Future Potential of Buccal Mucoadhesive Films as Drug Delivery Systems for Biologics 
      Montenegro-Nicolini, Miguel; Morales, Javier O. (Springer New York LLC, 2017)
      © 2016, American Association of Pharmaceutical Scientists.The main route of administration for drug products is the oral route, yet biologics are initially developed as injectables due to their limited stability through ...
    • Potential use of nanocarriers with pentacyclic triterpenes in cancer treatments 
      Valdés Camus, Karina; Morales, Javier; Rodríguez, Lennin; Günther Sapunar, Germán (Future Medicine Ltd, 2016-12)
      Ursolic, oleanolic and betulinic acids are representative pentacyclic triterpenoids found in various plants and fruits. Despite having marked antitumor potentials, the very poor water solubility of these triterpenes hinders ...
    • Preparation of a novel lipid-core micelle using a low-energy emulsification method 
      Fritz, Hans; Ortiz, Andrea; Velaga, Sitaram; Morales, Javier (Springer Verlag, 2018)
      High-energy methods for the manufacturing of nanomedicines are widely used; however, interest in low-energy methods is increasing due to their simplicity, better control over the process, and energy-saving characteristics ...
    • Substituent effect of side chains on the photochemical behavior of a new generation 1,4-dihydropyridine: ... 
      Cumsille, Sebastian; Morales, Javier O.; Sandoval Altamirano, Catalina; Guenther, Germán; Vega, Andrés; Pizarro, Nancy (Elsevier Science SA, 2018)
      Lercanidipine (LERCA) is a third generation antihypertensive drug belonging to the 1,4-dihydropyridine's family, which has been reported to induce photoallergic and/or phototoxic effects in patients with long term treatment. ...
    • The Effect of Inkjet Printing over Polymeric Films as Potential Buccal Biologics Delivery Systems 
      Montenegro-Nicolini, Miguel; Reyes, Patricio E.; Jara, Miguel O.; Vuddanda, Parameswara R.; Neira-Carrillo, Andrónico; Butto, Nicole; Velaga, Sitaram; Morales, Javier O. (Springer New York LLC, 2018)
      © 2018 American Association of Pharmaceutical Scientists The buccal mucosa appears as a promissory route for biologic drug administration, and pharmaceutical films are flexible dosage forms that can be used in the buccal ...