Browsing by Author "Faúndez Cáceres, Mario Antonio"

Now showing items 1-3 of 3

    • In vitro activity and mechanism of action against the protozoan parasite Trypanosoma cruzi of 5-nitrofuryl ... 
      Aguirre, G.; Boiani, Lucía; Cerecetto, Hugo; Fernández, M.; González, M.; Denicola, Ana; Otero, L.; Gambino, Dinorah; Rigol Olsen, Carolina; Olea Azar, Claudio; Faúndez Cáceres, Mario Antonio (PERGAMON-ELSEVIER SCIENCE LTD, 2004-09-15)
      The in vitro growth inhibition activity of new thiosemicarbazone derivatives against the protozoan parasite Trypanosoma cruzi, the causative agent of American trypanosomiasis, are described. The designed compounds combine ...
    • Liver microsomal biotransformation of nitro-aryl drugs: Mechanism for potential oxidative stress induction 
      Letelier Muñoz, María Eugenia; Izquierdo Lazo, Pamela Alejandra; Godoy Oviedo, Luis; Lepe Agrodnik, Ana María; Faúndez Cáceres, Mario Antonio (JOHN WILEY & SONS LTD, 2004-11)
      Toxic effects of several nitro-aryl drugs are attributed to the nitro-reduction that may be suffered in vivo, a reaction that may be catalysed by different reductases. One of these enzymes is NADPH-cytochrome P450 reductase, ...
    • Microsomal UDP-glucuronyltransferase in rat liver: Oxidative activation 
      Letelier Muñoz, María Eugenia; Pimentel Miranda, Alejandra Patricia; Pino, Patricia; Lepe Agrodnik, Ana María; Faúndez Cáceres, Mario Antonio; Aracena Parks, Paula; Speisky Cosoy, Hernán (BLACKWELL PUBLISHING, 2005-06)
      Activation of microsomal UDP-glucuronyltransferase (UDPGT) activity by treatment of hepatic microsomes with either detergents or Fe3+/ascorbate pro-oxidant system has been reported; however, definite mechanisms underlying ...