Browsing by Author "García Nannig, Lorena"

Now showing items 1-20 of 30

    • ATP-diphosphohydrolase activity in rat renal microvillar membranes and vascular tissue 
      Sandoval, S.; García Nannig, Lorena; Mancilla, Marta; Kettlun, Ana María; Collados, L. E.; Chayet, L.; Alvarez, A.; Traverso Cori, A.; Valenzuela Pedevila, María Antonieta (PERGAMON-ELSEVIER SCIENCE LTD, 1996-05)
      Ecto-nucleotidases may have a role in the regulation of purinoceptor-mediated responses. ATP-diphosphohydrolase or apyrase has been described as an ecto-nucleotidase, which is characterized by a low specificity for its ...
    • ATP-diphosphophydrolase activin in rat heart tissue 
      Espinosa, Victoria; Galleguillos, M.; Mancilla, Marta; Garrido, J.; Kettlun, Ana María; Collados, L. E.; Chayet, L.; García Nannig, Lorena; Traverso Cori, A.; Valenzuela Pedevila, María Antonieta (ACADEMIC PRESS AUST, 1996-08)
      Extracellular nucleotides interact with specific receptors on the cell surface and are locally metabolized by ecto-nucleotidases. Biochemical characterization of the ATPase and ADPase activities detected in rat heart ...
    • Characterization of ATP-diphosphohydrolase from rat mammary gland 
      Alvarez, A.; Chayet, L.; Galleguillos, M.; García Nannig, Lorena; Kettlun, Ana María; Collados, L. E.; Traverso Cori, A.; Mancilla, M.; Valenzuela Pedevila, María Antonieta (PERGAMON-ELSEVIER SCIENCE LTD, 1996-01)
      ATP-diphosphohydrolase (or apyrase) hydrolyses nucleoside di- and triphosphates in the presence of millimolar concentration of divalent cations. It is insensitive towards sulfhydryl and aliphatic hydroxyl-selective reagents ...
    • Comparison of the biochemical properties, regulation and function of ATP-diphosphohydrolase from human ... 
      Valenzuela Pedevila, María Antonieta; Kettlun, Ana María; Sandoval, S.; García Nannig, Lorena; Mancilla, Marta; Neckelmann, G.; Chayet, L.; Alvarez, A.; Cuevas, F.; Collados, L. E.; Espinosa, Victoria; Traverso Cori, A.; Bravo, I.; Acevedo, C. G.; Aranda, E. (ASSOC BRAS DIVULG CIENTIFICA, 1996-05)
      ATP-diphosphohydrolase (apyrase, EC 3.6.1.5) has both ATPase and ADPase activity that are stimulated by bivalent metals, with Ca2+ being the most effective. The possible physiological function of this enzyme, associated ...
    • Dexmedetomidine preconditioning activates pro-survival kinases and attenuates regional ischemia/reperfusion ... 
      Ibacache Figueroa, Mauricio; Sánchez, Gina; Gálvez, Felipe; Pedrozo Cibils, Zully; Humeres Martínez, Claudio; Echevarría, Ghislaine; Duaso, Juan; Hassi, Mario; García Nannig, Lorena; Díaz Araya, Guillermo; Lavandero González, Sergio (ELSEVIER, 2012-04)
      Pharmacological preconditioning limits myocardial infarct size after ischemia/reperfusion. Dexmedetomidine is an alpha(2)-adrenergic receptor agonist used in anesthesia that may have cardioprotective properties against ...
    • EPAC expression and function in cardiac fibroblasts and myofibroblasts 
      Olmedo, Ivonne; Muñoz, Claudia; Guzmán, Nancy; Catalán, Mabel; Vivar, Raúl; Ayala, Pedro; Humeres Martínez, Claudio; Aránguiz, Pablo; García Nannig, Lorena; Velarde, Victoria; Díaz Araya, Guillermo (Elsevier, 2013)
      In the heart, cardiac fibroblasts (CF) and cardiac myofibroblasts (CMF) are the main cells responsible for wound healing after cardiac insult. Exchange protein activated by cAMP (EPAC) is a downstream effector of cAMP, ...
    • Extracellular matrix protein expression in cerebrospinal fluid from patients with tropical spastic paraparesis ... 
      Cartier Rovirosa, Luis; García Nannig, Lorena; Kettlun, Ana María; Castañeda, P.; Collados, L. E.; Vásquez, F.; Giraudon, P.; Belin, M. F.; Valenzuela Pedevila, María Antonieta (TAYLOR & FRANCIS AS, 2004-04)
      The cerebrospinal fluid (CSF) is in direct contact with the extracellular space of the CNS, thus biochemical processes in the CNS could potentially be reflected in the CSF. Changes in extracellular matrix (ECM) proteins ...
    • Herpudl impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca2+-calcineurin-Akt ... 
      Navarro Márquez, Mario F.; Torrealba, Natalia; Troncoso, Rodrigo; Vásquez Trincado, César; Rodríguez, Marcelo; Morales, Pablo E.; Villalobos, Elisa; Eura, Yuka; García Nannig, Lorena; Chiong Lay, Mario; Klip, Amira; Jaimovich Pérez, Enrique; Kokame, Koichi; Lavandero González, Sergio (Elsevier, 2018)
      Skeletal muscle plays a central role in insulin-controlled glucose homeostasis. The molecular mechanisms related to insulin resistance in this tissue are incompletely understood. Herpud1 is an endoplasmic reticulum membrane ...
    • Increased Oxidative Stress Correlates With Pulmonary Vascular Response to Vasodilators in Pulmonary Artery ... 
      Castro Agüero, Pablo; Gabrielli, Luigi; Fasce, Fabrizio; Verdejo, Hugo; Greig, Douglas; Llevaneras, Silvana; Ferrada, Marcela; Hernández, Claudia; Godoy, Iván; García Nannig, Lorena; Mellado, Rose Marie; Sepúlveda, Pablo; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2009-03-10)
      Meeting Abstract
    • Inflamación y disfunción endotelial en pacientes con insuficiencia cardiaca crónica 
      Greig, Douglas; Castro, Pablo; Gabrielli, Luigi A.; Miranda, Rodrigo; Verdejo, Hugo; Alcaíno Gálvez, Hernán Alejandro; Bustos, Carlos; Chiong Lay, Mario; Godoy, Iván; Mellado, Rose Marie; García Nannig, Lorena; Salas, Daniela; Vivar Sánchez, Raúl; Vukasovic Ramírez, José Luis; Concepción, Roberto; Díaz Araya, Guillermo (SOC MEDICA SANTIAGO, 2008-06)
      Background: In chronic heart failure (CHF), endothelial dysfunction (ED) is a consequence of an imbalance of vascular tone regulating substances. The relationship between ED and inflammation has not been fully investigated. ...
    • Influence of glucose metabolism on vascular smooth muscle cell proliferation 
      Chiong Lay, Mario; Morales, Pablo Esteban; Torres, Gloria; Gutiérrez, Tómas; García Nannig, Lorena; Ibacache, Mauricio; Michea Acevedo, Luis (Hans Huber, 2013)
      Diff erentiation of vascular smooth muscle cells (VSMC) is an essential process of vascular development. VSMC have biosynthetic, proliferative, and contractile roles in the vessel wall. Alterations in the diff erentiated ...
    • Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide 
      Muñoz, Juan Pablo; Chiong Lay, Mario; García Nannig, Lorena; Troncoso Cotal, Rodrigo; Toro, Barbra; Pedrozo Cibils, Zully; Díaz Elizondo, Jessica; Salas, Daniela; Parra Ortíz, María Valentina; Núñez González, Marco; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2010-02-15)
      We investigate here the role of reactive oxygen species and nitric oxide in iron-induced cardiomyocyte hypertrophy or cell death Cultured rat cardiomyocytes incubated with 20 mu M iron (added as FeCl3-Na nitrilotriacetate, ...
    • Markedly increased Rho-kinase activity in circulating leukocytes in patients with chronic heart failure 
      Ocaranza, María Paz; Gabrielli, Luigi; Mora, Italo; García Nannig, Lorena; McNab, Paul; Godoy, Iván; Braun, Sandra; Córdova, Samuel; Castro, Pablo; Novoa, Ulises; Chiong Lay, Mario; Lavandero González, Sergio; Jalil, E. (MOSBY-ELSEVIER, 2011-05)
      Background The small guanosine triphosphatase Rho and its target Rho-kinase have significant roles in experimental remodeling and ventricular dysfunction, but no data are available on Rho-kinase activation in patients with ...
    • Microtubule proteins and their post-translational forms in the cerebrospinal fluid of patients with paraparesis ... 
      Maldonado, Horacio; Ortiz Riaño, Emilio Javier; Krause, Bernardo; Barriga, Andrés; Medina, Fernando; Pando, M. Elsa; Alberti, Carolina; Kettlun, Ana María; Collados, Lucía; García Nannig, Lorena; Cartier Rovirosa, Luis; Valenzuela Pedevila, María Antonieta (SOC BIOLGIA CHILE, 2008)
      HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is characterized by axonal degeneration of the corticospinal tracts. The specific requirements for transport of proteins and organelles to the distal ...
    • Mitochondria, myocardial remodeling, and cardiovascular disease 
      Verdejo, Hugo; Campo, Andrea del; Troncoso, Rodrigo; Gutiérrez, Tomás; Toro, Barbra; Quiroga, Clara; Pedrozo Cibils, Zully; Muñoz, Juan; García Nannig, Lorena; Castro, Pablo; Lavandero González, Sergio (2012)
      The process of muscle remodeling lies at the core of most cardiovascular diseases. Cardiac adaptation to pressure or volume overload is associated with a complex molecular change in cardiomyocytes which leads to anatomic ...
    • Phospholipase C/protein kinase C pathway mediates angiotensin II-dependent apoptosis in neonatal rat cardiac ... 
      Sánchez Vivar, Raúl; Soto, Cristián; Copaja, Miguel; Mateluna Guajardo, María Francisca; Aránguiz Urroz, Pablo Daniel; Muñoz, Juan Pablo; Chiong Lay, Mario; García Nannig, Lorena; Letelier Vargas, Alan Gonzalo; Thomas, W. G.; Lavandero González, Sergio; Díaz Araya, Guillermo (LIPPINCOTT WILLIAMS & WILKINS, 2008-08)
      Cardiac fibroblasts are the major non-myocyte cell constituent in the myocardium, and they are involved in heart remodeling. Angiotensin II type I receptor (AT(1)R), and changes in its expression have been reported in ...
    • Pleiotropic effects of atorvastatin in heart failure: Role in oxidative stress, inflammation, endothelial ... 
      Castro, P.; Miranda, Rodrigo; Verdejo, Hugo; Greig, Douglas; Gabrielli, Luigi; Alcaíno Olivares, Hernán Alejandro; Chiong Lay, Mario; Bustos Contreras, Carlos Andrés; García Nannig, Lorena; Mellado, Rose Marie; Vukasovic Ramírez, José Luis; Godoy, Iván; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2008-04)
      Background: Increased oxidative stress, a common feature in chronic heart failure, has been associated with inflammation, endothelial dysfunction, and extracellular matrix degradation. Statins have known anti-inflammatory ...
    • Polymorphisms in the RAC1 gene are associated with hypertension risk factors in a chilean pediatric population 
      Tapia Castillo, Alejandra; Carvajal, Cristian A.; Campino, Carmen; Vecchiola, Andrea; Allende, Fidel; Solari, Sandra; García Nannig, Lorena; Lavandero González, Sergio; Valdivia, Carolina; Fuentes, Cristobal; Lagos, Carlos F.; Martínez Aguayo, Alejandro; Baudrand, René; Aglony, Marlene; García, Hernán; Fardella, Carlos E. (Oxford University Press, 2014)
      The GTPase Rac1 has been implicated in hypertension as a modulator of mineralocorticoid receptor activity. Our aim is to investigate the frequency of polymorphisms rs10951982 (intron 1, G>A) and rs836478 (intron 3, T>C) ...
    • Potato tuber isoapyrases: Substrate specificity, affinity labeling, and proteolytic susceptibility 
      Kettlun, Ana María; Espinosa, V.; García Nannig, Lorena; Valenzuela, María Antonieta (PERGAMON-ELSEVIER SCIENCE LTD, 2005-05)
      Apyrase/ATP-diphosphohydrolase hydrolyzes di- and triphosphorylated nucleosides in the presence of a bivalent ion with sequential release of orthophosphate. We performed studies of substrate specificity on homogeneous ...
    • Regulation of Cardiac Autophagy by Insulin-like Growth Factor 1 
      Troncoso, Rodrigo; Díaz Elizondo, Jessica; Espinoza, Sandra P.; Navarro Márquez, Mario F.; Oyarzún, Alejandra P.; Riquelme, Jaime A.; García Carvajal, Ivonne; Díaz Araya, Guillermo; García Nannig, Lorena; Hill, Joseph A.; Lavandero González, Sergio (2013-07)
      Insulin-like growth factor-1 (IGF-1) signaling is a key pathway in the control of cell growth and survival. Three critical nodes in the IGF-1 signaling pathway have been described in cardiomyocytes: protein kinase ...